Double-blind randomised trial of co-amoxiclav versus placebo for persistent otitis media with effusion in general practice

The Lancet ◽  
1996 ◽  
Vol 348 (9029) ◽  
pp. 713-716 ◽  
Author(s):  
FAM van Balen ◽  
RA de Melker ◽  
FWMM Touw-Otten
Keyword(s):  
General Practice ◽  
Otitis Media ◽  
Otitis Media With Effusion ◽  
Randomised Trial ◽  
Double Blind

Efficacy of medical treatment as an adjunct to surgery in the treatment of secretory otitis media

1986 ◽  
Vol 100 (12) ◽  
pp. 1347-1350 ◽  
Author(s):  
T. H. J. Lesser ◽  
M. I. Clayton ◽  
D. Skinner
Keyword(s):  
Medical Treatment ◽  
Otitis Media ◽  
Middle Ear ◽  
Otitis Media With Effusion ◽  
Randomised Trial ◽  
Control Group ◽  
Middle Ear Effusion ◽  
Secretory Otitis Media ◽  
Ear Effusion

AbstractIn a pilot controlled randomised trial of 38 children who had bilateral secretory otitis media, with effusion demonstrated at operation, we compared the efficacy of a six-week course of an oral decongestant—antihistamine combination and a mucolytic preparation with a control group in preventing the presence of middle-ear effusion six weeks after myringotomy and adenoidectomy. The mucolytic preparation decreased the presence of middle-ear effusion when compared to the decongestant-antihistamine combination and the control group (p=0.06).

The follow up of Acute Otitis Media general practice

1995 ◽  
Vol 81 (2) ◽  
pp. 127-134
Author(s):  
A P Newton
Keyword(s):  
Primary Care ◽  
General Practice ◽  
Otitis Media ◽  
Otitis Media With Effusion ◽  
Acute Otitis Media ◽  
Care Team ◽  
Primary Care Team ◽  
Common Condition ◽  
Glue Ear

AbstractAcute Otitis Media is a common condition of childhood which potentially has a number of significant sequelae including the development of Otitis Media with Effusion (‘Glue Ear’). A general practice based study is described which assesses the implementation of a protocol for the follow up of Acute Otitis Media by the primary care team. The results of this study show that following the introduction of a follow up protocol a significantly improved rate of followup was achieved with resultant improvements in the identification of ‘Glue Ear’ and hence more appropriate referral for ENT care.

Comparison of Cefaclor and Amoxicillin for Acute Otitis Media with Effusion

1981 ◽  
Vol 90 (3_suppl2) ◽  
pp. 48-52 ◽  
Author(s):  
Ellen M. Mandel ◽  
Charles D. Bluestone ◽  
S. Nasrin Ghorbanian ◽  
Erdem I. Cantekin ◽  
Howard E. Rockette
Keyword(s):  
Clinical Trial ◽  
Otitis Media ◽  
Otitis Media With Effusion ◽  
Acute Otitis Media ◽  
Middle Ear Effusion ◽  
Double Blind ◽  
Days Of Therapy ◽  
The Difference ◽  
Reasonable Choice ◽  
Ear Effusion

A double-blind randomized clinical trial was conducted comparing cefaclor and amoxicillin for the treatment of acute otitis media with effusion in 110 children (150 ears). Each child underwent unilateral or bilateral tympanocentesis and then randomly received a 14-day course of either amoxicillin or cefaclor. Of 57 children in the cefaclor group, only 3 children (5.3%) had persistent or recurrent symptoms during the 14-day course of treatment, as compared to 5 of 53 children (9.4 %) in the amoxicillin group, but this difference is not significant. After completion of the 14 days of therapy, 45 of 76 ears (59.2%) of the children in the cefaclor group were effusion-free, as compared to only 28 of 64 ears (43.7%) of the children in the amoxicillin group. When adjusted for age and race, this difference is statistically significant (p = .03). However, the difference between the effect of the two antimicrobials is not statistically significant in children. Cefaclor is a reasonable choice for antimicrobial therapy for acute otitis media with effusion, and from these study findings, it appears that cefaclor may be more effective than amoxicillin in resolving the middle ear effusion at the completion of 14-day therapy.

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