Colchicine in Addition to Conventional Therapy for Acute Pericarditis: Results of the COlchicine for acute PEricarditis (COPE) Trial

SummaryThree cases have been presented who had a circulating antifactor VIII anticoagulant developing spontaneously in non-hemophilic subjects. Following two short courses of azathioprine in one case there were transient incomplete remissions of a degree not seen in the previous 4 months of observation. In the other two cases complete remissions were observed within three weeks of beginning administration of 6-mercaptopurine. In one of these, a brief relapse was retreated successfully. In 4 other cases not given these drugs and in cases reported in the literature, such a rapid remission was not seen to occur spontaneously and happened only infrequently in cases given corticosteroids. On the basis of this experience, we suggest that in the treatment of antifactor VIII, if the disorder shows no improvement with conventional therapy (blood, factor VIII concentrates, and corticosteroids), a trial with immunosuppressive drugs is warranted.

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Anaplastic thyroid carcinoma: The failure of conventional therapy but the real promise of targeted therapy

Endocrine Abstracts ◽

10.1530/endoabs.37.ep862 ◽

2015 ◽

Author(s):

Paul Lennon ◽

Sandra Deady ◽

Marie-Louise Healy ◽

John Kinsella ◽

Conrad Timon ◽

...

Keyword(s):

Targeted Therapy ◽

Thyroid Carcinoma ◽

Conventional Therapy ◽

Anaplastic Thyroid Carcinoma ◽

The Real

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730-P: At-Home Randomized Crossover Comparison of Automated Insulin Delivery vs. Conventional Therapy with Scheduled Meal Challenges

Diabetes ◽

10.2337/db20-730-p ◽

2020 ◽

Vol 69 (Supplement 1) ◽

pp. 730-P

Author(s):

JORDAN E. PINSKER ◽

SUNIL DESHPANDE ◽

MEI MEI CHURCH ◽

MOLLY PIPER ◽

CAMILLE C. ANDRE ◽

...

Keyword(s):

Conventional Therapy ◽

Insulin Delivery ◽

Crossover Comparison ◽

At Home

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Acute pericarditis and mediastinal lymph node abscess developing after endobronchial ultrasound guided transbronchial needle aspiration

Journal of Case Reports in Medicine ◽

10.25149/jcrm.v8i2.196 ◽

2019 ◽

Vol 8 (2) ◽

Author(s):

Shingo Nishikawa ◽

Ryo Ariyasu ◽

Tomoaki Sonoda ◽

Masafumi Saiki ◽

Takahiro Yoshizawa ◽

...

Keyword(s):

Lymph Node ◽

Mediastinal Lymph Node ◽

Tumor Therapy ◽

Needle Aspiration ◽

Lymph Node Biopsy ◽

Endobronchial Ultrasound ◽

Tumor Treatment ◽

Ultrasound Guided ◽

Transbronchial Needle Aspiration ◽

Acute Pericarditis

A 27-year-old man was diagnosed with inflammatory myofibroblastic tumor, and multiple lymph node and subcutaneous metastases. After several administrations of anti-tumor therapy, he underwent mediastinal lymph node biopsy using endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) to confirm tumor relapse. Five weeks later, he complained of chest pain, then rapidly developed shock due to acute pericarditis. Although he was treated with antibiotics for anaerobic bacterial infection and cardiac drainage, mediastinal lymph node abscess and pericarditis did not improve. After the surgical procedure, his physical condition dramatically improved and he was treated with another molecularly targeted therapy. Pericarditis associated with EBUS-TBNA is extremely rare. In this case, salvage was achieved by surgical drainage of the lymph node abscess and pericarditis, and long survival was obtained with further administration of anti-tumor treatment.

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