Comparison of cizolirtine citrate and metamizol sodium in the treatment of adult acute renal colic: A randomized, double-blind, clinical pilot study

Objectives. This study was established to compare single-dose lornoxicam 8 mg (NSAID) in addition to 0.15 mg.kg−1 ketamine with single-dose pethidine 50 mg, both administered intravenously (IV), on the quickness and extent of analgesia, disadvantage, and consequence on utilitarian situation. Patients and Methods. One hundred and twenty patients with acute renal colic pain received in emergency room were included in this prospective, randomized, and double blind clinical study. They were aimlessly designated into one of two groups using a computer-generated table. Group L received lornoxicam 8 mg IV plus 0.15 mg.kg−1 ketamine and Group P received pethidine 50 mg IV. Parameters were noticed at baseline and after 0, 15, 30, and 45 minutes and 1 hour after drug administration. The efficiency of the drug was determined by observing: patient rated pain, time to pain relief, rate of pain recurrence, the need for rescue analgesia, adverse events, and functional status. Results. The visual analogue scale was significantly lower in Group L after 30 minutes in comparison to Group P. In addition, there was statistically significant increase in Group P regarding their need for rescue analgesia after 30 min in comparison to Group L. Group P showed nonsignificantly increased sedation score compared to Group L. Conclusion. Patients receiving lornoxicam-ketamine attained greater reduction in pain scores and less side effects with better functional state and also are less likely to require further analgesia than those administered pethidine to control acute renal colic pain.

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MP-03.02: A double-blind, placebo-controlled comparison of voltaren and tramadol for acute renal colic

Urology ◽

10.1016/j.urology.2007.06.207 ◽

2007 ◽

Vol 70 (3) ◽

pp. 53

Author(s):

H. Ahmadnia ◽

M. Darabi ◽

S. Ghanbarizadeh ◽

M. Molaee ◽

M. Shokohian

Keyword(s):

Renal Colic ◽

Double Blind ◽

Double Blind Placebo ◽

Acute Renal Colic

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Comparison of Clinical Efficacy of Intravenous Acetaminophen with Intravenous Morphine in Acute Renal Colic: A Randomized, Double-Blind, Controlled Trial

Emergency Medicine International ◽

10.1155/2014/571326 ◽

2014 ◽

Vol 2014 ◽

pp. 1-5 ◽

Cited By ~ 13

Author(s):

Kambiz Masoumi ◽

Arash Forouzan ◽

Ali Asgari Darian ◽

Maryam Feli ◽

Hassan Barzegari ◽

...

Keyword(s):

Clinical Efficacy ◽

Renal Colic ◽

Controlled Trial ◽

Repeated Measure ◽

Morphine Group ◽

Double Blind ◽

Significant Difference ◽

Intravenous Acetaminophen ◽

Acute Renal Colic ◽

Intravenous Morphine

The aim of this study was to compare the clinical efficacy of intravenous acetaminophen with intravenous morphine in acute renal colic pain management. In this double-blind controlled trial, patients aged 18–55 years, diagnosed with acute renal colic, who met the inclusion and exclusion criteria, were randomized into two groups. First, using the visual analogue scale (VAS), intensity of pain was assessed in both groups. Then, one gram of intravenous acetaminophen or 0.1 mg/kg morphine was infused in 100 mL normal saline to either acetaminophen or morphine group. Intensity of pain was reassessed in 15, 30, 45, and 60 minutes according to VAS criteria. Finally, data from 108 patients were analyzed, 54 patients in each group. No significant difference was observed between the two groups in regard to sex (P=0.13), mean age (P=0.54), and baseline visual analogue score (P=0.21). A repeated measure analysis of variance revealed that the difference between the two treatments was significant (P=0.0001). The VAS reduction at primary endpoint (30 min after drug administration) was significantly higher in the acetaminophen group than in the morphine group (P=0.0001). This study demonstrated that intravenous acetaminophen could be more effective than intravenous morphine in acute renal colic patients’ pain relief.

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Diclofenac versus dipyrone in acute renal colic: A double-blind controlled trial

European Journal of Clinical Pharmacology ◽

10.1007/bf00544249 ◽

1987 ◽

Vol 33 (5) ◽

pp. 527-528 ◽

Cited By ~ 18

Author(s):

R. Miralles ◽

J. Cam� ◽

J. Guti�rrez ◽

J. Torn� ◽

J. M. Garc�s ◽

...

Keyword(s):

Renal Colic ◽

Controlled Trial ◽

Double Blind ◽

Acute Renal Colic

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Low-dose intravenous ketamine versus intravenous ketorolac in pain control in patients with acute renal colic in an emergency setting: a double-blind randomized clinical trial

The Korean Journal of Pain ◽

10.3344/kjp.2019.32.2.97 ◽

2019 ◽

Vol 32 (2) ◽

pp. 97-104 ◽

Cited By ~ 3

Author(s):

Mehran Sotoodehnia ◽

Mozhgan Farmahini-Farahani ◽

Arash Safaie ◽

Fatemeh Rasooli ◽

Alireza Baratloo

Keyword(s):

Clinical Trial ◽

Randomized Clinical Trial ◽

Pain Control ◽

Low Dose ◽

Renal Colic ◽

Emergency Setting ◽

Double Blind ◽

Acute Renal Colic ◽

Intravenous Ketamine ◽

Intravenous Ketorolac

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The NARC (Nonsteroidal Anti-inflammatory in Renal Colic) Trial. Single-dose intravenous ketorolac versus titrated intravenous meperidine in acute renal colic: a randomized clinical trial

CJEM ◽

10.1017/s1481803500004656 ◽

2000 ◽

Vol 2 (02) ◽

pp. 83-89 ◽

Cited By ~ 8

Author(s):

Victor M. Wood ◽

James M. Christenson ◽

Grant D. Innes ◽

Mary Lesperance ◽

R. Douglas McKnight

Keyword(s):

Single Dose ◽

Adverse Effects ◽

Functional Status ◽

Renal Colic ◽

Usual Activity ◽

Double Blind ◽

Convenience Sample ◽

Acute Renal Colic ◽

Anti Inflammatory ◽

Primary Hypothesis

ABSTRACTObjectives:Intravenous (IV) opioid titration is an accepted method of relieving acute renal colic. Studies have shown that nonsteroidal anti-inflammatory drugs (NSAIDs) are also effective in this setting. Our objective was to compare single-dose ketorolac and titrated meperidine, both administered intravenously, with respect to speed and degree of analgesia, adverse effects and functional status. Our primary hypothesis was that these agents provide equivalent analgesia within 60 minutes. Our secondary hypotheses were that ketorolac-treated patients would experience fewer adverse effects and would be better able to resume usual activity.Methods:This was a multicentre, double-blind randomized equivalence trial in a convenience sample of patients age 18–65 with moderate or severe renal colic, documented by intravenous pyelogram, ultrasound or stone passage. Meperidine-treated patients received 50 mg IV meperidine at 0 minutes, then 25–50 mg every 15 minutes as needed for ongoing pain. Ketorolac-treated patients received 30 mg IV ketorolac at 0 minutes and placebo injections every 15 minutes as needed. Pain levels and adverse effects were assessed every 15 minutes, and functional status was evaluated at 60 minutes. Our primary outcome was the proportion of patients with mild or no pain at 60 minutes.Results:Overall, 49 of 77 meperidine-treated patients (64%; 95% confidence interval [CI], 53%–75%) and 47 of 65 ketorolac-treated patients (72%; 95% CI, 61%–83%) achieved successful pain relief at 60 minutes (pvalue for equivalence = 0.002). Ten percent of meperidine-treated patients and 44% of ketorolac-treated patients were able to resume usual activity at 60 minutes (p= 0.001).Conclusions:In the doses studied, single-dose IV ketorolac is as effective as titrated IV meperidine for the relief of acute renal colic and causes less functional impairment.

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