Cognate antigen induced apoptosis of thymocytes and peripheral T cells

1997 ◽  
Vol 56 (1-3) ◽  
pp. 82
Author(s):  
A Wack
Keyword(s):  
T Cells ◽  
Peripheral T Cells ◽  
Cognate Antigen ◽  
Induced Apoptosis

Cognate antigen induced apoptosis of thymocytes and peripheral T cells

1997 ◽  
Vol 56 ◽  
pp. 82
Author(s):  
A. Wack ◽  
O. Williams ◽  
P. Corbella ◽  
I.N. Crispe ◽  
D. Kioussis
Keyword(s):  
T Cells ◽  
Peripheral T Cells ◽  
Cognate Antigen ◽  
Induced Apoptosis

scholarly journals A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis.

1996 ◽  
Vol 183 (4) ◽  
pp. 1789-1796 ◽  
Author(s):  
G Süss ◽  
K Shortman
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Cd4 T Cells ◽  
Fas Ligand ◽  
Activated T Cells ◽  
T Cell Apoptosis ◽  
Peripheral T Cells ◽  
Surface Staining ◽  
Induced Apoptosis ◽  
Antigen Presenting

Dendritic cells (DC), the most efficient antigen-presenting cells, are well equipped for activation of naive CD4+ T cells by their expression of high levels of major histocompatibility complex and costimulator molecules. We now demonstrate that some DC are equally well equipped for killing these same T cells. Murine splenic DC consist of both conventional CD8alpha- DC and a major population of CD8alpha+ DC. Whereas CD8- DC induce a vigorous proliferative response in CD4 T cells, CD8+ DC induce a lesser response that is associated with marked T cell apoptosis. By using various mixtures of T cells and DC from Fas-mutant lpr/lpr mice and Fas-ligand (FasL) mutant gld/gld mice, we show this death is due to interaction of Fas on activated T cells with FasL on CD8+ DC. Furthermore, we show by direct surface staining that CD8+ DC, but not CD8- DC, express FasL at high levels. These findings indicate that FasL+ CD8+ DC are a specialized subgroup of DC with a role in the regulation of the response of primary peripheral T cells.

CD2 induced apoptosis of peripheral T cells

1997 ◽  
Vol 29 (5) ◽  
pp. 2377-2378 ◽  
Author(s):  
M. Rouleau ◽  
B. Mollereau ◽  
A. Bernard ◽  
D. Metivier ◽  
M.A. Rosenthal-Allieri ◽  
...  
Keyword(s):  
T Cells ◽  
Peripheral T Cells ◽  
Induced Apoptosis

scholarly journals Perturbed Homeostasis of Peripheral T Cells Elicits Decreased Susceptibility to Anti-CD3-Induced Apoptosis in Prediabetic Nonobese Diabetic Mice

2004 ◽  
Vol 173 (7) ◽  
pp. 4407-4416 ◽  
Author(s):  
Wen Yang ◽  
Shabbir Hussain ◽  
Qing-Sheng Mi ◽  
Pere Santamaria ◽  
Terry L. Delovitch
Keyword(s):  
T Cells ◽  
Diabetic Mice ◽  
Nonobese Diabetic ◽  
Peripheral T Cells ◽  
Induced Apoptosis ◽  
Nonobese Diabetic Mice

scholarly journals T Cells of Different Developmental Stages Differ in Sensitivity to Apoptosis Induced by Extracellular NAD

2002 ◽  
Vol 9 (4) ◽  
pp. 197-202 ◽  
Author(s):  
Friedrich Haag ◽  
Dunja Freese ◽  
Felix Scheublein ◽  
Wiebke Ohlrogge ◽  
Sahil Adriouch ◽  
...  
Keyword(s):  
T Cells ◽  
Developmental Stages ◽  
Extracellular Nucleotides ◽  
Resting Cells ◽  
Surface Molecules ◽  
Peripheral Lymph ◽  
Peripheral T Cells ◽  
Induced Apoptosis ◽  
Adp Ribosyltransferase ◽  
Selection Of

Extracellular nucleotides such as ATP and NAD can profoundly affect the functions of lymphocytes, macrophages, and other cells. We have recently shown that extracellular NAD induces rapid apoptosis in naive T cells by a mechanism involving the ADP-ribosylation of cell surface molecules. In the present paper, we describe that T cells of different developmental stages differ in their sensitivity to NAD-induced apoptosis. Thymocytes were less susceptible than peripheral lymph node T cells, and freshly activated cells were more resistant than resting cells. Sensitivity to NAD-induced apoptosis generally correlated with expression of the ADP-ribosyltransferase ART2.2, which is not expressed on thymocytes and shed from peripheral T cells upon activation. Our findings suggest that NAD-induced apoptosis does not play a role during thymic selection of T cells, but rather may play a role by preventing the activation of unwanted bystander T cells during an immune response, and thus may participate in the control of autoimmunity.

scholarly journals Protection from anti-TCR/CD3-induced apoptosis in immature thymocytes by a signal through thymic shared antigen-1/stem cell antigen-2.

1996 ◽  
Vol 183 (5) ◽  
pp. 2355-2360 ◽  
Author(s):  
S Noda ◽  
A Kosugi ◽  
S Saitoh ◽  
S Narumiya ◽  
T Hamaoka
Keyword(s):  
T Cells ◽  
Stem Cell ◽  
T Cell ◽  
Activated T Cells ◽  
Cell Surface Molecule ◽  
Newborn Mice ◽  
Cell Antigen ◽  
Peripheral T Cells ◽  
Induced Apoptosis

During T cell development in the thymus, the expression of thymic shared antigen-1 (TSA-1)/stem cell antigen-2 (Sca-2), a glycosylphosphatidylinositol (GPI)-anchored differentiation antigen, is developmentally regulated. The expression level of TSA-1 is the highest in most immature CD4- CD8- thymocytes, high in CD4+ CD8+ thymocytes, but barely detectable in mature CD4+ CD8- or CD4- CD8- thymocytes and peripheral T cells. We have previously shown that surface TSA-1 expression in peripheral T cells is induced upon activation and that anti-TSA-1 mAb inhibits the T cell receptor (TCR) signaling pathway in activated T cells. In the present study, we have analyzed a role of TSA-1 in thymic selection events, especially in TCR-mediated apoptosis. In in vitro experiments, anti-TSA-1 blocked anti-CD3-induced cell death of T cell hybridomas. When anti-TSA-1 was injected into newborn mice in vivo together with anti-CD3 epsilon or anti-TCR-beta, TCR/CD3-mediated apoptosis of thymocytes was almost completely blocked. The blockade of apoptosis was defined by the inhibition of, first, the decrease in total number of thymocytes; second, the decrease in percentages of CD4+ CD8+ thymocytes; and third, the induction of DNA fragmentation. However, anti-TSA-1 did not block either steroid- or radiation-induced apoptosis, indicating that a signal via TSA-1 does not inhibit a common pathway of thymocyte apoptosis. Since TCR-mediated apoptosis is pivotal in thymic ontogeny, these results suggest that TSA-1/Sca-2 is an important cell surface molecule regulating the fate of a developing T cell.

CD4 mAb induced apoptosis of peripheral T cells: multiparameter subpopulation analysis by flow cytometry using Attractors™

2001 ◽  
Vol 257 (1-2) ◽  
pp. 71-82 ◽  
Author(s):  
J Fishman-Lobell ◽  
P Tsui ◽  
M Reddy ◽  
R DiPrinzio ◽  
C Eichman ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
T Cells ◽  
Peripheral T Cells ◽  
Induced Apoptosis
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