894 poster Acute diarrhea during pelvic irradiation: is small-bowel volume effect different in gynecologic patients with prior abdomen operation or not?

2004 ◽  
Vol 73 ◽  
pp. S379-S380
2005 ◽  
Vol 97 (1) ◽  
pp. 118-125 ◽  
Author(s):  
Eng-Yen Huang ◽  
Hsuan-Chih Hsu ◽  
Kuender D. Yang ◽  
Hao Lin ◽  
Feng-Sheng Wang ◽  
...  

2013 ◽  
Vol 54 (5) ◽  
pp. 909-918 ◽  
Author(s):  
Shih-Chen Chang ◽  
Hsiao-Fei Lee ◽  
Hui-Min Ting ◽  
Tzu-Chao Pan ◽  
Shu-Yu Liu ◽  
...  

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 497
Author(s):  
Eng-Yen Huang ◽  
Yu-Ming Wang ◽  
Shih-Chen Chang ◽  
Shu-Yu Liu ◽  
Ming-Chung Chou

We studied the association of rectal dose with acute diarrhea in patients with gynecologic malignancies undergoing whole-pelvic (WP) intensity-modulated radiotherapy (IMRT). From June 2006 to April 2019, 108 patients with previous hysterectomy who underwent WP IMRT were enrolled in this cohort study. WP irradiation of 39.6–45 Gy/22–25 fractions was initially delivered to the patients. Common Terminology Criteria for Adverse Events (CTCAE) version 3 was used to evaluate acute diarrhea during radiotherapy. Small bowel volume at different levels of isodose curves (Vn%) and mean rectal dose (MRD) were measured for statistical analysis. The multivariate analysis showed that the MRD ≥ 32.75 Gy (p = 0.005) and small bowel volume of 100% prescribed (V100%) ≥ 60 mL (p = 0.008) were independent factors of Grade 2 or higher diarrhea. The cumulative incidence of Grade 2 or higher diarrhea at 39.6 Gy were 70.5%, 42.2%, and 15.0% (p < 0.001) in patients with both high (V100% ≥ 60 mL and MRD ≥ 32.75 Gy), either high, and both low volume-dose factors, respectively. Strict constraints for the rectum/small bowel or image-guided radiotherapy to reduce these doses are suggested.


Author(s):  
Seung Jae Huh ◽  
Do Hoon Lim ◽  
Yong Chan Ahn ◽  
Dae Yong Kim ◽  
Moon Kyung Kim ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document