PO-0945: Small Molecule HQ5 as a multimodal imaging agent for radiotherapy-induced tumor cell death

2014 ◽  
Vol 111 ◽  
pp. S124-S125
Author(s):  
M.A. Stammes ◽  
A. Maeda ◽  
E.R. Beek van ◽  
T.J.A. Snoeks ◽  
R.S. DaCosta ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Cell ◽  
Small Molecule ◽  
Multimodal Imaging ◽  
Imaging Agent ◽  
Tumor Cell Death

scholarly journals The Necrosis-Avid Small Molecule HQ4-DTPA as a Multimodal Imaging Agent for Monitoring Radiation Therapy-Induced Tumor Cell Death

2016 ◽  
Vol 6 ◽  
Author(s):  
Marieke A. Stammes ◽  
Azusa Maeda ◽  
Jiachuan Bu ◽  
Deborah A. Scollard ◽  
Iris Kulbatski ◽  
...  
Keyword(s):  
Cell Death ◽  
Radiation Therapy ◽  
Tumor Cell ◽  
Small Molecule ◽  
Multimodal Imaging ◽  
Imaging Agent ◽  
Tumor Cell Death

Abstract 4451: Novel small molecule AG311 induces tumor cell death through inhibition of mitochondrial electron transport

2015 ◽  
Author(s):  
Anja Bastian ◽  
Lora C. Bailey-Downs ◽  
Jessica E. Thorpe ◽  
Ravi Kumar Vyas Devambatla ◽  
Aleem Gangjee ◽  
...  
Keyword(s):  
Cell Death ◽  
Electron Transport ◽  
Tumor Cell ◽  
Small Molecule ◽  
Tumor Cell Death

T-3256336, a novel and orally available small molecule IAP antagonist, induced tumor cell death via induction of systemic TNF alpha production

2016 ◽  
Vol 479 (2) ◽  
pp. 179-185 ◽  
Author(s):  
Hiroyuki Sumi ◽  
Masakazu Inazuka ◽  
Kentaro Hashimoto ◽  
Tomoyasu Ishikawa ◽  
Sei Yoshida ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Cell ◽  
Small Molecule ◽  
Tnf Alpha ◽  
Tumor Cell Death ◽  
Alpha Production ◽  
Iap Antagonist

scholarly journals CB002, a novel p53 tumor suppressor pathway-restoring small molecule induces tumor cell death through the pro-apoptotic protein NOXA

Cell Cycle ◽  
2018 ◽  
Vol 17 (5) ◽  
pp. 557-567 ◽  
Author(s):  
Liz J. Hernandez-Borrero ◽  
Shengliang Zhang ◽  
Amriti Lulla ◽  
David T. Dicker ◽  
Wafik S. El-Deiry
Keyword(s):  
Cell Death ◽  
Tumor Suppressor ◽  
Tumor Cell ◽  
Small Molecule ◽  
Tumor Cell Death ◽  
P53 Tumor Suppressor ◽  
Apoptotic Protein

scholarly journals Optoacoustic Detection of Early Therapy-Induced Tumor Cell Death Using a Targeted Imaging Agent

2017 ◽  
Vol 23 (22) ◽  
pp. 6893-6903 ◽  
Author(s):  
Bangwen Xie ◽  
Michal R. Tomaszewski ◽  
André A. Neves ◽  
Susana Ros ◽  
De-En Hu ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Cell ◽  
Imaging Agent ◽  
Targeted Imaging ◽  
Tumor Cell Death ◽  
Early Therapy

scholarly journals Abstract 2866: Volumetric optoacoustic imaging of tumor cell death using a targeted imaging agent

2017 ◽  
Author(s):  
Bangwen Xie ◽  
Michal Tomaszewski ◽  
André A. Neves ◽  
Stefanie R. Mullins ◽  
David Tice ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Cell ◽  
Imaging Agent ◽  
Targeted Imaging ◽  
Tumor Cell Death ◽  
Optoacoustic Imaging

scholarly journals Cellular cytotoxicity is a form of immunogenic cell death

2020 ◽  
Vol 8 (1) ◽  
pp. e000325 ◽  
Author(s):  
Luna Minute ◽  
Alvaro Teijeira ◽  
Alfonso R Sanchez-Paulete ◽  
Maria C Ochoa ◽  
Maite Alvarez ◽  
...  
Keyword(s):  
T Cells ◽  
Cell Death ◽  
Dendritic Cells ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Cd8 T Cells ◽  
Immunogenic Cell Death ◽  
Cell Debris ◽  
Tumor Cell Death ◽  
Mhc Multimer

BackgroundThe immune response to cancer is often conceptualized with the cancer immunity cycle. An essential step in this interpretation is that antigens released by dying tumors are presented by dendritic cells to naive or memory T cells in the tumor-draining lymph nodes. Whether tumor cell death resulting from cytotoxicity, as mediated by T cells or natural killer (NK) lymphocytes, is actually immunogenic currently remains unknown.MethodsIn this study, tumor cells were killed by antigen-specific T-cell receptor (TCR) transgenic CD8 T cells or activated NK cells. Immunogenic cell death was studied analyzing the membrane exposure of calreticulin and the release of high mobility group box 1 (HMGB1) by the dying tumor cells. Furthermore, the potential immunogenicity of the tumor cell debris was evaluated in immunocompetent mice challenged with an unrelated tumor sharing only one tumor-associated antigen and by class I major histocompatibility complex (MHC)-multimer stainings. Mice deficient inBatf3,Ifnar1andSting1were used to study mechanistic requirements.ResultsWe observe in cocultures of tumor cells and effector cytotoxic cells, the presence of markers of immunogenic cell death such as calreticulin exposure and soluble HMGB1 protein. Ovalbumin (OVA)-transfected MC38 colon cancer cells, exogenously pulsed to present the gp100 epitope are killed in culture by mouse gp100-specific TCR transgenic CD8 T cells. Immunization of mice with the resulting destroyed cells induces epitope spreading as observed by detection of OVA-specific T cells by MHC multimer staining and rejection of OVA+EG7 lymphoma cells. Similar results were observed in mice immunized with cell debris generated by NK-cell mediated cytotoxicity. Mice deficient inBatf3-dependent dendritic cells (conventional dendritic cells type 1, cDC1) fail to develop an anti-OVA response when immunized with tumor cells killed by cytotoxic lymphocytes. In line with this, cultured cDC1 dendritic cells uptake and can readily cross-present antigen from cytotoxicity-killed tumor cells to cognate CD8+T lymphocytes.ConclusionThese results support that an ongoing cytotoxic antitumor immune response can lead to immunogenic tumor cell death.

Photodynamic Therapy with Liposomal Zinc Phthalocyanine and Tirapazamine Increases Tumor Cell Death via DNA Damage

2017 ◽  
Vol 13 (2) ◽  
pp. 204-220 ◽  
Author(s):  
Mans Broekgaarden ◽  
Ruud Weijer ◽  
AlbertC. van Wijk ◽  
RuudC. Cox ◽  
MaartenR. Egmond ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cell Death ◽  
Photodynamic Therapy ◽  
Tumor Cell ◽  
Zinc Phthalocyanine ◽  
Tumor Cell Death
Sign in / Sign up

Export Citation Format

Share Document