Expressional changes of Shc family mRNAs during mouse development and functional analysis of N-Shc

2000 ◽  
Vol 38 ◽  
pp. S68
Author(s):  
M Sato
2000 ◽  
Vol 20 (7) ◽  
pp. 2498-2504 ◽  
Author(s):  
Laurie Jo Kurihara ◽  
Ekaterina Semenova ◽  
John M. Levorse ◽  
Shirley M. Tilghman

ABSTRACT Mice homozygous for the s1Acrg deletion at the Ednrb locus arrest at embryonic day 8.5. To determine the molecular basis of this defect, we initiated positional cloning of the s1Acrg minimal region. The mouseUch-L3 (ubiquitin C-terminal hydrolase L3) gene was mapped within the s1Acrg minimal region. BecauseUch-L3 transcripts were present in embryonic structures relevant to the s1Acrg phenotype, we created a targeted mutation in Uch-L3 to address its role during development and its possible contribution to thes1Acrg phenotype. Mice homozygous for the mutation Uch-L3Δ3-7 were viable, with no obvious developmental or histological abnormalities. Although high levels of Uch-L3 RNA were detected in testes and thymus,Uch-L3Δ3-7 homozygotes were fertile, and no defect in intrathymic T-cell differentiation was detected. We conclude that the s1Acrg phenotype is either complex and multigenic or due to the loss of another gene within the region. We propose that Uch-L3 may be functionally redundant with its homologue Uch-L1.


10.1038/90074 ◽  
2001 ◽  
Vol 28 (3) ◽  
pp. 241-249 ◽  
Author(s):  
Kevin J. Mitchell ◽  
Kathy I. Pinson ◽  
Olivia G. Kelly ◽  
Jane Brennan ◽  
Joel Zupicich ◽  
...  

2003 ◽  
Vol 19 (3) ◽  
pp. 164-174 ◽  
Author(s):  
Stephen N. Haynes ◽  
Andrew E. Williams

Summary: We review the rationale for behavioral clinical case formulations and emphasize the role of the functional analysis in the design of individualized treatments. Standardized treatments may not be optimally effective for clients who have multiple behavior problems. These problems can affect each other in complex ways and each behavior problem can be influenced by multiple, interacting causal variables. The mechanisms of action of standardized treatments may not always address the most important causal variables for a client's behavior problems. The functional analysis integrates judgments about the client's behavior problems, important causal variables, and functional relations among variables. The functional analysis aids treatment decisions by helping the clinician estimate the relative magnitude of effect of each causal variable on the client's behavior problems, so that the most effective treatments can be selected. The parameters of, and issues associated with, a functional analysis and Functional Analytic Clinical Case Models (FACCM) are illustrated with a clinical case. The task of selecting the best treatment for a client is complicated because treatments differ in their level of specificity and have unequally weighted mechanisms of action. Further, a treatment's mechanism of action is often unknown.


1958 ◽  
Vol 3 (6) ◽  
pp. 158-160
Author(s):  
LAWRENCE SCHLESINGER

1973 ◽  
Author(s):  
Robert M. Leve ◽  
Lydia Burdick ◽  
Patricia Fontaine

2011 ◽  
Author(s):  
Stella Tamburello ◽  
Paolo Scapellato ◽  
Anna Contardi ◽  
Ettore De Monte ◽  
Loredana Rosiello

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