A floating-type oral dosage form for piroxicam based on hollow polycarbonate microspheres: in vitro and in vivo evaluation in rabbits

Over the last few years, therapeutic efficacy of drugs that have poor bioavailability or narrow absorption window have challenged the pharmaceutical industry. In this framework, many Hydrodynamic Balance System (HBS) also known as Gastro retentive dosage forms (GRDFs) have been used to enhance the therapeutic efficacy of drugs. Such drug have a narrow absorption window, are unstable at higher pH, are soluble in acidic conditions, and are local effect in the gastric-part. The drug development with recent technology of various novel polymeric-based gastroretentive drug delivery technologies that may regulate the bioavailability and extend time of therapeutic efficacy of such drugs. Our focus on the significance of in vitro study and in vivo evaluation parameters of various HBS drugs along with their applications. This study provides a promising platform for advantages and guide formulation of HBS dosage form were covered in detail.

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In Vivo Evaluation of Oral Dosage Form Performance

Developing Solid Oral Dosage Forms ◽

10.1016/b978-0-444-53242-8.00016-3 ◽

2009 ◽

pp. 365-378 ◽

Cited By ~ 2

Author(s):

Honghui Zhou ◽

Kathleen Seitz

Keyword(s):

Dosage Form ◽

Oral Dosage ◽

In Vivo Evaluation ◽

Oral Dosage Form

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A level A in vitro/in vivo correlation in fasted and fed states using different methods: Applied to solid immediate release oral dosage form

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2005.08.006 ◽

2006 ◽

Vol 27 (1) ◽

pp. 72-79 ◽

Cited By ~ 75

Author(s):

Sabah Souliman ◽

Stéphanie Blanquet ◽

Eric Beyssac ◽

Jean-Michel Cardot

Keyword(s):

Dosage Form ◽

Immediate Release ◽

Oral Dosage ◽

Oral Dosage Form

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FORMULATION AND IN-VITRO-IN-VIVO EVALUATION OF ALGINATE-CHITOSAN MICROSPHERES OF GLIPIZIDE BY IONIC GELATION METHOD

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i7.18725 ◽

2017 ◽

Vol 10 (7) ◽

pp. 385 ◽

Cited By ~ 1

Author(s):

Maya Sharma ◽

Choudhury Pk ◽

Suresh Kumar Dev

Keyword(s):

Sustained Release ◽

Dosage Form ◽

Oral Dosage ◽

Ionic Gelation ◽

In Vivo Evaluation ◽

Chitosan Microspheres ◽

Model Drug ◽

Effective Use

Objective: The present work is aimed to formulate and evaluate alginate-chitosan microspheres of glipizide for the effective use in the treatment of diabetes.Methods: Sustained release microspheres were prepared by gentle mixing of polymers in water phase with drug by agitation. The polymers used for preparation were sodium alginate and chitosan, which was extruded into 5% calcium chloride solution to produce microspheres by ionic gelation method.Results: Single unit dosage form of Glipizide causes gastric irritation. To convert it in to the multiple unit dosage form will release the drug evenly throughout the stomach which suppresses the irritation. The aim of study towards formulation and evaluation of alginate-chitosan microspheres, which can provide sustained release of the model drug. It shows better in-vitro and in-vivo activity than conventional dosage forms. The work also aims to study various parameters affecting the behavior of microspheres in oral dosage form. Conclusion: Drugs that are simply absorbed from the gastrointestinal tract (GIT) and having a short half life are eliminated rapidly from the blood flow. To avoid this trouble, the oral sustained release (SR) has been developed as these will release the drug slowly in to the GIT and maintain a stable drug concentration in the serum for a longer period of time.

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