scholarly journals Future outlook hydrodynamic drug delivery system of solid oral dosage form: Review

2021 ◽  
Vol 6 (3) ◽  
pp. 96-101
Author(s):  
Akhilesh Kumar Singh ◽  
Neeraj Sharma
Keyword(s):  
Drug Delivery ◽  
Therapeutic Efficacy ◽  
Dosage Form ◽  
In Vitro Study ◽  
Local Effect ◽  
Oral Dosage ◽  
In Vivo Evaluation ◽  
Absorption Window

Over the last few years, therapeutic efficacy of drugs that have poor bioavailability or narrow absorption window have challenged the pharmaceutical industry. In this framework, many Hydrodynamic Balance System (HBS) also known as Gastro retentive dosage forms (GRDFs) have been used to enhance the therapeutic efficacy of drugs. Such drug have a narrow absorption window, are unstable at higher pH, are soluble in acidic conditions, and are local effect in the gastric-part. The drug development with recent technology of various novel polymeric-based gastroretentive drug delivery technologies that may regulate the bioavailability and extend time of therapeutic efficacy of such drugs. Our focus on the significance of in vitro study and in vivo evaluation parameters of various HBS drugs along with their applications.  This study provides a promising platform for advantages and guide formulation of HBS dosage form were covered in detail.

scholarly journals FORMULATION AND IN-VITRO-IN-VIVO EVALUATION OF ALGINATE-CHITOSAN MICROSPHERES OF GLIPIZIDE BY IONIC GELATION METHOD

2017 ◽  
Vol 10 (7) ◽  
pp. 385 ◽  
Author(s):  
Maya Sharma ◽  
Choudhury Pk ◽  
Suresh Kumar Dev
Keyword(s):  
Sustained Release ◽  
Dosage Form ◽  
Oral Dosage ◽  
Ionic Gelation ◽  
In Vivo Evaluation ◽  
Chitosan Microspheres ◽  
Model Drug ◽  
Effective Use

Objective: The present work is aimed to formulate and evaluate alginate-chitosan microspheres of glipizide for the effective use in the treatment of diabetes.Methods: Sustained release microspheres were prepared by gentle mixing of polymers in water phase with drug by agitation. The polymers used for preparation were sodium alginate and chitosan, which was extruded into 5% calcium chloride solution to produce microspheres by ionic gelation method.Results: Single unit dosage form of Glipizide causes gastric irritation. To convert it in to the multiple unit dosage form will release the drug evenly throughout the stomach which suppresses the irritation. The aim of study towards formulation and evaluation of alginate-chitosan microspheres, which can provide sustained release of the model drug. It shows better in-vitro and in-vivo activity than conventional dosage forms. The work also aims to study various parameters affecting the behavior of microspheres in oral dosage form. Conclusion:  Drugs that are simply absorbed from the gastrointestinal tract (GIT) and having a short half life are eliminated rapidly from the blood flow. To avoid this trouble, the oral sustained release (SR) has been developed as these will release the drug slowly in to the GIT and maintain a stable drug concentration in the serum for a longer period of time.

scholarly journals Physicochemical, in vitro and in vivo evaluation of flurbiprofen microemulsion

2015 ◽  
Vol 87 (3) ◽  
pp. 1823-1831 ◽  
Author(s):  
MUHAMMAD NAEEM ◽  
NISAR UR RAHMAN ◽  
GUILHERME. D. TAVARES ◽  
SÁVIO F. BARBOSA ◽  
NÁDIA B. CHACRA ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Administration ◽  
Skin Irritation ◽  
In Vitro Study ◽  
Alcoholic Solution ◽  
Gastric Bleeding ◽  
In Vivo Evaluation ◽  
Gastrointestinal Side Effects

ABSTRACTFlurbiprofen, a potent nonsteroidal anti-inflammatory drug, is widely used for relief of pain in patients suffering from rheumatic diseases, migraine, sore throat and primary dysmenorrheal. However, this drug has many gastrointestinal side effects produced by its oral administration, such as gastric bleeding and peptic ulcer. These effects were responsible for non-compliance among patients, which ultimately results in treatment failure. The physicochemical properties of flurbiprofen, make it a suitable candidate for transdermal drug delivery, which can overcome the drawbacks of oral administration. In this sense, microemulsions have been proved to increase the cutaneous absorption of lipophilic drugs when compared to conventional drug delivery systems. The purpose of this study was to formulate and characterize gel based microemulsions, for topical delivery of flurbiprofen. Different gel bases, containing microemulsion and hydro-alcoholic solution of flurbiprofen, were developed and compared. In vitro study showed that gels containing microemulsion had a higher permeation rate than those containing hydro-alcoholic solutions. Additionally, formulation of Carbopol-I (microemulsion) showed higher percent of inhibition of inflammation than others bases. Further, skin irritation study demonstrated that Carbopol-I was none irritating. Flurbiprofen microemulsion incorporated on Carbopol-I showed physicochemical, in vitro and in vivo characteristics suitable for the development of alternative transdermal delivery formulation.

scholarly journals Statistical optimization of alginate-based oral dosage form of 5-aminosalicylic acid aimed to colonic delivery: In vitro and in vivo evaluation

2019 ◽  
Vol 52 ◽  
pp. 177-188 ◽  
Author(s):  
Ehsan Kaffash ◽  
Farinaz Saremnejad ◽  
Mohammadreza Abbaspour ◽  
Seyed Ahmad Mohajeri ◽  
Hadi Afrasiabi Garekani ◽  
...  
Keyword(s):  
Dosage Form ◽  
Statistical Optimization ◽  
Oral Dosage ◽  
Aminosalicylic Acid ◽  
Colonic Delivery ◽  
In Vivo Evaluation ◽  
Oral Dosage Form

In vitro and in vivo evaluation of an oral system for time and/or site-specific drug delivery

2001 ◽  
Vol 73 (1) ◽  
pp. 103-110 ◽  
Author(s):  
M.E Sangalli ◽  
A Maroni ◽  
L Zema ◽  
C Busetti ◽  
F Giordano ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Specific Drug ◽  
In Vivo Evaluation ◽  
Site Specific

scholarly journals GASTRORETENTIVE DRUG DELIVERY SYSTEMS: FROM CONCEPTION TO COMMERCIAL SUCCESS

2017 ◽  
Vol 4 (2) ◽  
pp. 10 ◽  
Author(s):  
Harshil P. Shah ◽  
Shailesh T. Prajapati ◽  
C. N. Patel
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Oral Route ◽  
Delivery Systems ◽  
Present Review ◽  
Gastric Residence Time ◽  
In Vivo Characterization ◽  
Absorption Window

Despite the extensive advancements in the field of drug delivery, the oral route remains the favorable route for administration of therapeutic actives. A success of oral controlled drug delivery systems is associated with reduced dosing frequency, decreased fluctuation in plasma drug concentration profile along with improved patient compliance. However, they are also associated with challenges like shorter gastric residence time, unpredictable gastric emptying and poor bioavailability for some molecules. This has initiated tremendous advancements in the field of gastro-retention to achieve controlled release of drugs along with improved bioavailability of drugs with narrow absorption window as well as localized action in the stomach and upper part of GIT. In present review, efforts have been envisaged to summarize our current understanding in the field of gastro-retention and their in vitro as well as in vivo characterization. Present review also highlights commercially utilized gastro-retentive technologies and some recently granted US patents in the field of GRDDS.

Swellable and porous bilayer tablet for gastroretentive drug delivery: Preparation and in vitro-in vivo evaluation

2019 ◽  
Vol 572 ◽  
pp. 118783
Author(s):  
Kyu-Mok Hwang ◽  
Thi-Tram Nguyen ◽  
Su Hyun Seok ◽  
Hyun-Il Jo ◽  
Cheol-Hee Cho ◽  
...  
Keyword(s):  
Drug Delivery ◽  
In Vivo Evaluation ◽  
Bilayer Tablet
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