666 IMPLICATION OF TRAIL/DR5 INTERNALIZATION IN LIVER TUMOR CELL APOPTOSIS

2011 ◽  
Vol 54 ◽  
pp. S269
Author(s):  
Y. Akazawa ◽  
H. Isomoto ◽  
K. Nakao ◽  
G. Gores
Keyword(s):  
Tumor Cell ◽  
Liver Tumor ◽  
Cell Apoptosis ◽  
Tumor Cell Apoptosis ◽  
Liver Tumor Cell

scholarly journals Jianpi-Huayu Formula Inhibits Development of Hepatocellular Carcinoma by Regulating Expression of miR-602, Which Targets the RASSF1A Gene

2020 ◽  
Vol 19 ◽  
pp. 153473541990080 ◽  
Author(s):  
Yajing Huang ◽  
Cheng Zhou ◽  
Huihong Wen ◽  
Yongxu Chen ◽  
Yingjie Xie ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Protein Expression ◽  
Tumor Cell ◽  
Liver Tumor ◽  
Cell Apoptosis ◽  
Control Group ◽  
Tumor Cell Apoptosis ◽  
Expression Levels ◽  
Rassf1a Gene ◽  
Tumor Tissues

The traditional Chinese medicine formula Jianpi-Huayu (JPHY) has been reported to be effective in the treatment of hepatocellular carcinoma (HCC). However, its underlying mechanism remains unclear. In this article, we employed an orthotopic transplantation model in nude mice to explore whether JPHY could inhibit the development of HCC by regulating miR-602, which targets the Ras association domain-containing protein 1A (RASSF1A) pathway. HCC SMMC-7721 cells were treated with JPHY to test whether the RASSF1A gene as mediated by miR-602 affected the proliferation and apoptosis of tumor cells. We subsequently detected miR-602, RASSF1A, and tumor cell apoptosis–related markers in cells and liver tumor tissues. We observed that mice treated with JPHY had smaller tumors and higher survival rates than untreated ones. Similarly, JPHY-treated SMMC-7721 cells exhibited alterations in morphology and higher cytotoxicity compared with the control group. Furthermore, we found that JPHY decreased overexpression of miR-602 and increased protein expression levels of the RASS1A gene, which in turn altered protein expression levels of tumor cell apoptosis–related genes in the cells and liver tumor tissues of drug-treated mice. These results indicated that JPHY could potentially be used to treat HCC by targeting miR-602, which targets the RASSF1A gene, which in turn plays a major role in HCC pathogenesis.

Mechanism of TRAIL Induced Tumor Cell Apoptosis and Application of TRAIL Based on Tumor Therapy

2012 ◽  
Vol 28 (6) ◽  
pp. 448 ◽  
Author(s):  
Ling ZHU ◽  
Xiangxi WANG ◽  
Xuemei LI ◽  
Jinliang YANG
Keyword(s):  
Tumor Cell ◽  
Cell Apoptosis ◽  
Tumor Therapy ◽  
Tumor Cell Apoptosis

scholarly journals Hsp60 Regulation of Tumor Cell Apoptosis

2007 ◽  
Vol 283 (8) ◽  
pp. 5188-5194 ◽  
Author(s):  
Jagadish C. Ghosh ◽  
Takehiko Dohi ◽  
Byoung Heon Kang ◽  
Dario C. Altieri
Keyword(s):  
Tumor Cell ◽  
Cell Apoptosis ◽  
Tumor Cell Apoptosis

Synthesis and Characterization of 4,11-Diaminoanthra[2,3-b]furan-5,10-diones: Tumor Cell Apoptosis through tNOX-Modulated NAD+/NADH Ratio and SIRT1

2015 ◽  
Vol 58 (24) ◽  
pp. 9522-9534 ◽  
Author(s):  
Alexander S. Tikhomirov ◽  
Andrey E. Shchekotikhin ◽  
Yi-Hui Lee ◽  
Yi-Ann Chen ◽  
Chia-An Yeh ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Apoptosis ◽  
Synthesis And Characterization ◽  
Tumor Cell Apoptosis ◽  
Nadh Ratio

Combination of porphyrins and DNA-alkylation agents: Synthesis and tumor cell apoptosis induction

2006 ◽  
Vol 14 (4) ◽  
pp. 1068-1077 ◽  
Author(s):  
Hanping He ◽  
Yan Zhou ◽  
Feng Liang ◽  
Dongqing Li ◽  
Juanjuan Wu ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Apoptosis ◽  
Dna Alkylation ◽  
Apoptosis Induction ◽  
Tumor Cell Apoptosis
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