P0692 : PKC/AP-1 signaling drives transcription of interferon-stimulated genes and exerts potent antiviral activity against hepatitis C and E viruses

2015 ◽  
Vol 62 ◽  
pp. S581-S582
Author(s):  
W. Wang ◽  
Y. Wang ◽  
X. Zhou ◽  
Y. Yin ◽  
L. Xu ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Antiviral Activity ◽  
Interferon Stimulated Genes ◽  
Potent Antiviral Activity

Potent antiviral activity of Solanum rantonnetii and the isolated compounds against hepatitis C virus in vitro

2014 ◽  
Vol 11 ◽  
pp. 185-191 ◽  
Author(s):  
Khaled Rashed ◽  
Marie-Emmanuelle Sahuc ◽  
Gaspard Deloison ◽  
Noémie Calland ◽  
Priscille Brodin ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiviral Activity ◽  
Potent Antiviral Activity

Expressional screening of interferon-stimulated genes for antiviral activity against hepatitis C virus replication

2006 ◽  
Vol 13 (10) ◽  
pp. 690-700 ◽  
Author(s):  
Y. Itsui ◽  
N. Sakamoto ◽  
M. Kurosaki ◽  
N. Kanazawa ◽  
Y. Tanabe ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiviral Activity ◽  
Virus Replication ◽  
Interferon Stimulated Genes

scholarly journals Smp76, a Scorpine-Like Peptide Isolated from the Venom of the Scorpion Scorpio maurus palmatus, with a Potent Antiviral Activity Against Hepatitis C Virus and Dengue Virus

2019 ◽  
Vol 26 (2) ◽  
pp. 811-821 ◽  
Author(s):  
Alaa M. H. El-Bitar ◽  
Moustafa Sarhan ◽  
Mohamed A. Abdel-Rahman ◽  
Veronica Quintero-Hernandez ◽  
Chie Aoki-Utsubo ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiviral Activity ◽  
Dengue Virus ◽  
Potent Antiviral Activity

AT-527, a pan-genotypic purine nucleotideprodrug, exhibits potent antiviral activity in subjects with chronic hepatitis C

2018 ◽  
Vol 68 ◽  
pp. S282 ◽  
Author(s):  
X.-J. Zhou ◽  
E. Berliba ◽  
F. Vanhoutte ◽  
M. Bogus ◽  
P.-J. Berghmans ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Antiviral Activity ◽  
Chronic Hepatitis C ◽  
Potent Antiviral Activity

Sofosbuvir plus daclatasvir for post-transplant recurrent hepatitis C: Potent antiviral activity but no clinical benefit if treatment is given late

2014 ◽  
Vol 46 (10) ◽  
pp. 923-927 ◽  
Author(s):  
Adriano M. Pellicelli ◽  
Marzia Montalbano ◽  
Raffaella Lionetti ◽  
Christine Durand ◽  
Peter Ferenci ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Antiviral Activity ◽  
Clinical Benefit ◽  
Post Transplant ◽  
Recurrent Hepatitis ◽  
Potent Antiviral Activity ◽  
Recurrent Hepatitis C

scholarly journals Interleukin-1 Inhibits Hepatitis C Virus Subgenomic RNA Replication by Activation of Extracellular Regulated Kinase Pathway

2003 ◽  
Vol 77 (9) ◽  
pp. 5493-5498 ◽  
Author(s):  
Haizhen Zhu ◽  
Chen Liu
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Antiviral Activity ◽  
Interleukin 1 ◽  
Rna Replication ◽  
Inhibitory Effect ◽  
Chronic Infections ◽  
Subgenomic Replicon ◽  
Subgenomic Rna ◽  
Interferon Stimulated Genes

ABSTRACT Interleukin-1 (IL-1) plays an important role in the inflammatory process. Some studies have demonstrated that IL-1 production was impaired in patients with chronic infections of hepatitis C virus (HCV), implying that IL-1 may play a role in viral clearance. Using an HCV subgenomic replicon cell line, we demonstrate that IL-1 can effectively inhibit HCV subgenomic RNA replication and viral protein expression, suggesting that IL-1 has direct antiviral activity. The inhibitory effect is associated with the extracellular regulatory kinase (ERK) activation. In addition, we also show that IL-1 can induce one of the interferon-stimulated genes (ISGs), 1-8U, which exhibits antiviral activity. However, it has no effect on the other ISG, 6-16, suggesting that IL-1 induces novel antiviral pathways within a cell.

scholarly journals Importance of Apolipoprotein A-I and A-II Composition in HDL and Its Potential for Studying COVID-19 and SARS-CoV-2

Medicines ◽  
2021 ◽  
Vol 8 (7) ◽  
pp. 38
Author(s):  
Kyung-Hyun Cho
Keyword(s):  
Antiviral Activity ◽  
High Density ◽  
High Density Lipoproteins ◽  
Potent Antiviral Activity ◽  
Apolipoprotein A ◽  
Putative Role

The composition and properties of apolipoprotein (apo) A-I and apoA-II in high-density lipoproteins (HDL) might be critical to SARS-CoV-2 infection via SR-BI and antiviral activity against COVID-19. HDL containing native apoA-I showed potent antiviral activity, while HDL containing glycated apoA-I or other apolipoproteins did not. However, there has been no report to elucidate the putative role of apoA-II in the antiviral activity of HDL.

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