Impact of IL28B genotype on response rates in hepatitis C virus cirrhotic patients treated with new DAA regimens: experience of a single center

Portal vein thrombosis is a catastrophe not uncommonly complicating hepatitis C virus-related liver cirrhosis. To estimate its prevalence and clinical characteristics, we investigated 1000 cirrhotic patients by abdominal ultrasound or Doppler study at least. Portal vein thrombosis was found in 21.6%, of whom 157 (72.7%) had malignancy. Complete portal vein thrombosis was found in 70.4%. Half of all these patients had at least one episode of portal hypertensive bleeding, a third had abdominal pain and a quarter presented with jaundice. Portal bilopathy was diagnosed in two cases (0.9%). There was significant association between severity of liver disease, ascites, male gender and site of segmental focal lesion and portal vein thrombosis.

Download Full-text

Natural Cytotoxicity Receptor–Dependent Natural Killer Cytolytic activity Directed at Hepatitis C Virus (HCV) Is Associated With Liver Inflammation, African American Race, IL28B Genotype, and Response to Pegylated Interferon/Ribavirin Therapy in Chronic HCV Infection

The Journal of Infectious Diseases ◽

10.1093/infdis/jit677 ◽

2013 ◽

Vol 209 (10) ◽

pp. 1591-1601 ◽

Cited By ~ 6

Author(s):

Qinglai Meng ◽

M. R. Sandhya Rani ◽

Julia M. Sugalski ◽

Chelsey J. Judge ◽

Sarah Phat ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Pegylated Interferon ◽

Cytolytic Activity ◽

Il28b Genotype ◽

Liver Inflammation ◽

Natural Cytotoxicity ◽

Chronic Hcv Infection ◽

Chronic Hcv ◽

African American Race

Download Full-text

Safety, Tolerability, and Preliminary Efficacy of the Anti-Fibrotic Small Molecule PRI-724, a CBP/β-Catenin Inhibitor, in Patients with Hepatitis C Virus-related Cirrhosis: A Single-Center, Open-Label, Dose Escalation Phase 1 Trial

EBioMedicine ◽

10.1016/j.ebiom.2017.08.016 ◽

2017 ◽

Vol 23 ◽

pp. 79-87 ◽

Cited By ~ 24

Author(s):

Kiminori Kimura ◽

Akemi Ikoma ◽

Maki Shibakawa ◽

Shinji Shimoda ◽

Kenichi Harada ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Small Molecule ◽

Dose Escalation ◽

Phase 1 ◽

Single Center ◽

Open Label ◽

Phase 1 Trial ◽

Label Dose

Download Full-text

Hepatocellular carcinoma in patients undergoing orthotopic liver transplantation: radiological findings with anatomopathological correlation in Brazil

Arquivos de Gastroenterologia ◽

10.1590/s0004-28032006000100008 ◽

2006 ◽

Vol 43 (1) ◽

pp. 24-29 ◽

Cited By ~ 3

Author(s):

Antônio Carlos Maciel ◽

Carlos Thadeu Cerski ◽

Roger Klein Moreira ◽

Vinicius Labrea Resende ◽

Maria Lúcia Zanotelli ◽

...

Keyword(s):

Computed Tomography ◽

Hepatocellular Carcinoma ◽

Liver Transplantation ◽

Hepatitis C Virus ◽

Hepatitis C ◽

Orthotopic Liver Transplantation ◽

Imaging Techniques ◽

Arterial Phase ◽

Hepatitis C Virus Infection ◽

Cirrhotic Patients

BACKGROUND: Hepatocellular carcinoma is one of the most common malignant tumors worldwide. Imaging techniques, specially computed tomography and ultrasound, are among the most useful diagnostic tools, although the accuracy of these methods may have a significant variability. AIMS: To determine the prevalence of hepatocellular carcinoma in cirrhotic patients undergoing orthotopic liver transplantation at "Santa Casa de Misericórdia" of Porto Alegre, RS, Brazil; to estimate the sensitivity of computed tomography and ultrasound in pretransplantation detection of hepatocellular carcinoma in this population; to correlate the radiological characteristics with anatomopathological findings. MATERIALS AND METHODS: Retrospective prevalence study. Population: adult, cirrhotic patients undergoing orthotopic liver transplantation from January 1990 to July 2003. Among the 292 transplanted patients, 31 cases of hepatocellular carcinoma were diagnosed, of which 29 were included in the study. Tumor characteristics in both ultrasound and computed tomography were compared to those observed in anatomopathological examination. RESULTS: Prevalence of hepatitis C virus infection among patients with diagnosis of hepatocellular carcinoma was 93.5%, and the prevalence of hepatocellular carcinoma among transplanted patients was 10.6%. The overall sensitivity of the imaging techniques was 70.3% for computed tomography and 72% for ultrasound. CONCLUSION: The prevalence of hepatocellular carcinoma at our institution, as well as the sensitivity of both ultrasound and computed tomography to detect such tumors at pretransplantation screening were similar to those found by other authors, while the prevalence of hepatitis C virus infection, the most common etiological agent for liver disease in our patients, is one of the highest ever reported in literature. Factors influencing hepatocellular carcinoma detection rates were: time from examination to liver transplantation; acquisition of computed tomography images during arterial phase; lesion size. Arterial phase proved to be the most useful part of computed tomography examination in this study.

Download Full-text