Gene expression studies of mRNAs encoding the NMDA receptor subunits NMDAR1, NMDAR2A, NMDAR2B, NMDAR2C, and NMDAR2D following long-term treatment with cis- and trans-flupenthixol as a model for understanding the mode of action of schizophrenia drug treatment

1998 ◽  
Vol 54 (1) ◽  
pp. 92-100 ◽  
Author(s):  
Andrew Chih-Hui Chen ◽  
Bernard McDonald ◽  
Stephen J Moss ◽  
Hugh M.D Gurling
Keyword(s):  
Gene Expression ◽  
Nmda Receptor ◽  
Drug Treatment ◽  
Mode Of Action ◽  
Term Treatment ◽  
Expression Studies ◽  
Long Term Treatment ◽  
Gene Expression Studies ◽  
Cis And Trans

scholarly journals Confirmation of the mode of action of anesthetic‐induced developmental neurotoxicity with gene expression studies

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
William Slikker ◽  
Qiang Shi ◽  
Lei Guo ◽  
Tucker A Patterson ◽  
Stacey Dial ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mode Of Action ◽  
Developmental Neurotoxicity ◽  
Expression Studies ◽  
Gene Expression Studies

scholarly journals Shrinking the Psoriasis Assessment Gap: Early Gene-Expression Profiling Accurately Predicts Response to Long-Term Treatment

2017 ◽  
Vol 137 (2) ◽  
pp. 305-312 ◽  
Author(s):  
Joel Correa da Rosa ◽  
Jaehwan Kim ◽  
Suyan Tian ◽  
Lewis E. Tomalin ◽  
James G. Krueger ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Term Treatment ◽  
Early Gene ◽  
Early Gene Expression ◽  
Long Term Treatment

scholarly journals Long-Term Treatment with Lopinavir-Ritonavir Induces a Reduction in Peripheral Adipose Depots in Mice

2006 ◽  
Vol 50 (12) ◽  
pp. 3998-4004 ◽  
Author(s):  
Matthieu Prot ◽  
Laurence Heripret ◽  
Nathalie Cardot-Leccia ◽  
Christophe Perrin ◽  
Myriam Aouadi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Highly Active Antiretroviral Therapy ◽  
Fold Increase ◽  
Term Treatment ◽  
Long Period ◽  
Highly Active ◽  
Long Term Treatment ◽  
Immunodeficiency Virus ◽  
Lipodystrophic Syndrome

ABSTRACT Highly active antiretroviral therapy (HAART) of human immunodeficiency virus-infected patients is associated with adverse effects, such as lipodystrophy and hyperlipidemia. The lipodystrophic syndrome is characterized by a peripheral lipoatrophy and/or fat accumulation in the abdomen and neck. In order to get insights into the physiopathological mechanisms underlying this syndrome, we treated mice with protease inhibitors (PIs) over a long period of time. Although atazanavir-treated mice presented the same circulating triglyceride concentration as control mice, lopinavir-ritonavir-treated mice rapidly became hypertriglyceridemic, with triglyceride levels of 200 mg/dl, whereas control and atazanavir-treated animals had triglyceride levels of 80 mg/dl. These results obtained with mice reproduce the metabolic disorder observed in humans. White adipose tissue (WAT) was analyzed after 8 weeks of treatment. Compared to the control or atazanavir treatment, lopinavir-ritonavir treatment induced a significant 25% weight reduction in the peripheral inguinal WAT depot. By contrast, the profound epididymal WAT depot was not affected. This effect was associated with a 5.5-fold increase in SREBP-1c gene expression only in the inguinal depot. Our results demonstrate that the long-term treatment of mice with PIs constitutes an interesting experimental model with which some aspects of the lipoatrophy induced by HAART in humans may be studied.

A STUDY OF THE ANTITHYROID EFFECT OF TOLBUTAMIDE

1962 ◽  
Vol 25 (3) ◽  
pp. 343-350 ◽  
Author(s):  
G. HANNO ◽  
H. K. AWWAD
Keyword(s):  
Thyroid Function ◽  
Mode Of Action ◽  
Salivary Secretion ◽  
Inhibitory Effect ◽  
Drug Dose ◽  
Term Treatment ◽  
Antithyroid Drugs ◽  
Total Drug ◽  
Long Term Treatment

SUMMARY The mechanism of the antithyroid effect of tolbutamide was investigated by studying its effect on thyroid iodine trapping, the salivary secretion of 131I and the organic binding of thyroid 131I. No inhibitory effect was noted on iodine trapping. After prolonged therapy a defect in the organic binding of 131I was observed in some cases. There was a significant correlation between thyroid function as measured by the 2 hr. neck:thigh ratio and the total drug dose in patients on long-term treatment. Recovery of the gland from this defect after withdrawal of the drug seemed to be slower than the recovery from other antithyroid drugs having the same mode of action.

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