Risk of cutaneous malignant melanoma in patients with nonfamilial atypical nevi from a pigmented lesions clinic

1999 ◽  
Vol 40 (5) ◽  
pp. 686-693 ◽  
Author(s):  
Dyon G.C.T.M. Snels ◽  
Elysée T.M. Hille ◽  
Nelleke A. Gruis ◽  
Wilma Bergman
Keyword(s):  
Malignant Melanoma ◽  
Cutaneous Malignant Melanoma ◽  
Pigmented Lesions ◽  
Atypical Nevi

scholarly journals Bilateral Choroidal Metastases as Presentation of Dissemination of Cutaneous Malignant Melanoma

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
S. Fernandez-Perez ◽  
O. Ruiz-Moreno ◽  
V. Pueyo ◽  
G. de la Mata ◽  
L. Pablo
Keyword(s):  
Malignant Melanoma ◽  
Cutaneous Melanoma ◽  
Posterior Pole ◽  
Cutaneous Malignant Melanoma ◽  
Pathological Examination ◽  
Blurred Vision ◽  
Pigmented Lesions ◽  
Multiple Metastases ◽  
Exhaustive Study ◽  
The Right

Case Report. A 47-year-old man presented with blurred vision in the right eye. Ophthalmoscopic examination showed several placoid, pigmented lesions in the posterior pole and midperiphery of the retina of both eyes.Results. Patient referred a cutaneous malignant melanoma on the back skin removed 6 years ago. A systemic workup revealed multiple metastases in liver and spleen. After an exhaustive study we concluded that it was a dissemination of a cutaneous malignant melanoma with bilateral choroidal metastases, liver and spleen metastases. The patient obtained clinical ocular improvement after palliative chemotherapy, although he died in the following months. Pathological examination of the lesions confirmed the diagnosis of choroidal metastases from a malignant cutaneous melanoma.Conclusions. Monitoring patients who have had cutaneous malignant melanoma is very important, since melanoma metastases may occur even many years after the diagnosis of the primary tumor. Choroidal metastases from cutaneous melanoma are uncommon but we should be aware because their appearance worsens prognosis.

scholarly journals Association between Oral Contraceptives and cutaneous melanoma: a systematic review and metanalysis

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
I Giacchetta ◽  
M Chiavarini ◽  
G Naldini ◽  
R Fabiani
Keyword(s):  
Systematic Review ◽  
Malignant Melanoma ◽  
Publication Bias ◽  
Oral Contraceptives ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Cutaneous Malignant Melanoma ◽  
Hormonal Factors ◽  
Increased Risk

Abstract Background The probability of developing invasive cutaneous malignant melanoma (CMM) is higher in women than in men up until the age of 49. Several studies investigated the association between hormonal factors and CMM. The aim of this systematic review and meta-analysis is to summarize the evidence on the association between Oral Contraceptives (OC) and the risk of CMM. Methods This review and meta-analysis follow the PRISMA guidelines. A systematic literature search was conducted on Medline and Web of Science until December 2019. Studies were eligible if reported a risk estimate for the association between OC and CMM. Heterogeneity testing was performed using Cochran's Q and I2 statistics. Publication bias was assessed by Egger's test and Begg's test. Meta-analysis was performed using random effect model. Results The results of the pooled analysis of all 32 studies showed no significant association between OC and the risk of CMM (OR 1.02; 95% CI 0.94-1.11; I2=39.32%, p = 0.013). The stratified analyses by study design found no significant association between OC and the risk of CMM neither in the 18 case-control studies (OR 1.02; 95% CI 0.87-1.21; I2=56.91%, p = 0.002) nor in the 14 cohort studies (OR 1.04; 95% CI 0.98-1.11; I2=0.00%, p = 0.557). No significant publication bias could be detected by Egger's test or Begg's test. Conclusions This meta-analysis of available literature suggests no significant association between OC and the risk of developing CMM. Further investigations are needed to evaluate the possible relationship of OC use and other hormonal factors potentially contributing to the increased risk of CMM in women during their reproductive years. Key messages Oral contraceptives (OC) do not significantly contribute to the risk of Cutaneous Malignant Melanoma (CMM). Further studies are needed to investigate the potential role of other hormonal factors in the increased probability of developing CMM in women during their reproductive years.

Birth outcome in Danish women with cutaneous malignant melanoma

2007 ◽  
Vol 17 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Vivian Langagergaard ◽  
Erzsebet H. Puho ◽  
Timothy L. Lash ◽  
Bente N??rg??rd ◽  
Henrik T. S??rensen
Keyword(s):  
Malignant Melanoma ◽  
Birth Outcome ◽  
Cutaneous Malignant Melanoma
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