Octreotide Scintigraphy for the Detection of Paragangliomas

2000 ◽  
Vol 122 (3) ◽  
pp. 358-362 ◽  
Author(s):  
Fred F. Telischi ◽  
Andres Bustillo ◽  
Michelle L. H. Whiteman ◽  
Aldo N. Serafini ◽  
Michael J. Reisberg ◽  
...  
Keyword(s):  
Head And Neck ◽  
Neuroendocrine Tumors ◽  
False Negative ◽  
Neck Region ◽  
Synchronous Tumors ◽  
Head And Neck Region ◽  
Octreotide Scintigraphy ◽  
Octreotide Scan ◽  
Head And Neck Paragangliomas

Paragangliomas are neuroendocrine tumors located primarily in the head and neck region, but they can also occur at other sites. Confirming the preoperative diagnosis and detecting synchronous tumors may be difficult in some patients. Octreotide is a somatostatin analog that, when coupled to a radioisotope, produces a scintigraphic image of tumors expressing somatostatin type 2 receptors. Paragangliomas, like many neuroendocrine tumors, have been found to have a high density of somatostatin type 2 receptors on the cell surface. This study compared the results of preoperative octreotide scintigraphy with the histopathology in 21 patients who underwent surgery for presumed head and neck paragangliomas. Octreotide scan findings were positive in 16 patients with paragangliomas and negative in 3 patients with other pathology. One false-positive and 1 false-negative result were obtained. Thus, this test had an accuracy of 90%, a sensitivity of 94%, and a specificity of 75%. Previously unidentified synchronous tumors were identified in 5 patients. On the basis of this series of patients, octreotide scintigraphy appears to be a reliable test to detect paragangliomas and may be quite helpful in preoperative planning.

Octreotide scintigraphy for the detection of paragangliomas

2000 ◽  
Vol 122 (3) ◽  
pp. 358-362 ◽  
Author(s):  
Fred F. Telischi ◽  
Andres Bustillo ◽  
Michelle L. H. Whiteman ◽  
Aldo N. Serafini ◽  
Michael J. Reisberg ◽  
...  
Keyword(s):  
Head And Neck ◽  
Neuroendocrine Tumors ◽  
False Negative ◽  
Neck Region ◽  
Synchronous Tumors ◽  
Head And Neck Region ◽  
Octreotide Scintigraphy ◽  
Octreotide Scan ◽  
Head And Neck Paragangliomas

Paragangliomas are neuroendocrine tumors located primarily in the head and neck region, but they can also occur at other sites. Confirming the preoperative diagnosis and detecting synchronous tumors may be difficult in some patients. Octreotide is a somatostatin analog that, when coupled to a radioisotope, produces a scintigraphic image of tumors expressing somatostatin type 2 receptors. Paragangliomas, like many neuroendocrine tumors, have been found to have a high density of somatostatin type 2 receptors on the cell surface. This study compared the results of preoperative octreotide scintigraphy with the histopathology in 21 patients who underwent surgery for presumed head and neck paragangliomas. Octreotide scan findings were positive in 16 patients with paragangliomas and negative in 3 patients with other pathology. One false-positive and 1 false-negative result were obtained. Thus, this test had an accuracy of 90%, a sensitivity of 94%, and a specificity of 75%. Previously unidentified synchronous tumors were identified in 5 patients. On the basis of this series of patients, octreotide scintigraphy appears to be a reliable test to detect paragangliomas and may be quite helpful in preoperative planning.

Accumulation of 99mTc-Glutathione in Head and Neck Tumors

1994 ◽  
Vol 33 (05) ◽  
pp. 224-228 ◽  
Author(s):  
T. Aras ◽  
A. Aktaş ◽  
S. Kaya ◽  
C. F. Bekdik ◽  
M. T. Ercan
Keyword(s):  
Head And Neck ◽  
Soft Tissues ◽  
Malignant Tumors ◽  
False Negative ◽  
Neck Region ◽  
Head And Neck Tumors ◽  
Blood Clearance ◽  
True Negative ◽  
Head And Neck Region ◽  
Neck Tumors

SummaryGlutathione labelled with 99mTc was used to study blood clearance and normal distribution in 3 healthy volunteers and in 10 patients with biopsy-proven tumors in the head and neck region. Static scintigrams were obtained at 1, 3, 6, and 24 h. ROIs over tumors and normal soft tissues were compared to obtain T/N ratios. In normal subjects blood clearance reached a plateau at 6 h; no radioactivity accumulation in the head and neck region was observed. Only the cardiac blood pool, the liver, the kidneys and the urinary bladder were evident. Excretion was via the kidneys. Malignant tumors and metastases were well visualized in 7 patients (true-positive), starting at 1 h. The mean T/N ratio was 2.69 ± 0.77. The best images were obtained at 3-6 h. 1 false-positive (granula-matous reaction), 1 false-negative (malignant epithelial tumor in the radix of tongue) and 1 true-negative (angiofibroma) results were obtained. 99mTc-GSH is a potential radiopharmaceutical for the scintigraphic visualization of head and neck tumors. Further clinical studies are warranted to show its sensitivity and accuracy.

scholarly journals Cytodiagnosis of extra-nasal rhinosporidiosis: A study of 16 cases from endemic area

2014 ◽  
Vol 6 (02) ◽  
pp. 080-083
Author(s):  
Subrata Pal ◽  
Srabani Chakrabarti ◽  
Biplab Kr Biswas ◽  
Rajani Sinha ◽  
Arindam Rakshit ◽  
...  
Keyword(s):  
Head And Neck ◽  
Fine Needle Aspiration ◽  
Preoperative Diagnosis ◽  
False Negative ◽  
Neck Region ◽  
Needle Aspiration ◽  
Diagnostic Dilemma ◽  
Head And Neck Region ◽  
Fine Needle ◽  
Negative Case

ABSTRACT Context: Extra-nasal rhinosporidiosis is not uncommon in endemic region like India. Clinical presentations of extra-nasal rhinosporidiosis lesion often lead to diagnostic dilemma. Cytology can help in the preoperative diagnosis of such lesions. Aims: The aims of our study were to find the clinico-pathological presentation of extra-nasal rhinosporidiosis and to evaluate the role of cytology in diagnosing these lesions preoperatively. Settings and Design: Fine-needle aspiration cytology is often used for preoperative diagnosis of sub-cutaneous lesions of the head and neck region. This retrospective study was designed to include the cytologically diagnosed cases of rhinosporidiosis and to compare with final histopathology of the lesions. Materials and Methods: A total of 21 cases of extra-nasal rhinosporidiosis were diagnosed in our study period of 18 months. Cytology was approached in 17 cases and 16 cases were diagnosed as rhinosporidiosis, which were included in the study group. Twelve cases were sampled by fine-needle aspiration and four cases by scrap technique. Histopathological confirmation was possible in all cytologically diagnosed cases. Results: Head and neck region were involved in 15 cases and only one case was on the skin of right upper arm. Orbital region was the most common extra-nasal site of involvement. Most of the cases (13 cases, 81.25%) belonged to the age group of 11-30 years. All cytologicaly diagnosed cases of rhinosporidiosis were concordant with histopathology. Only one false-negative case was cytologically diagnosed as suppurative inflammatory lesion. Sensitivity and specificity of cytology in diagnosis of extra-nasal rhinosporidiosis were 94.11% and 100% respectively. Conclusions: Extra-nasal rhinosporidiosis is an important differential diagnosis of nodular, polypoid mass of head-neck-face region. Cytology can be used as an important tool in preoperative diagnosis of extra-nasal rhinosporidiosis.

scholarly journals The effectiveness of oral propranolol for infantile hemangioma on the head and neck region: A case series

2021 ◽  
pp. 106120
Author(s):  
Prasetyanugraheni Kreshanti ◽  
Nandya Titania Putri ◽  
Valencia Jane Martin ◽  
Chaula Luthfia Sukasah
Keyword(s):  
Head And Neck ◽  
Case Series ◽  
Neck Region ◽  
Infantile Hemangioma ◽  
Head And Neck Region ◽  
Oral Propranolol

scholarly journals Therapeutic Strategies for Untreated Capillary Malformations of the Head and Neck Region: A Systematic Review and Meta-Analyses

2021 ◽  
Author(s):  
Gonca Cinkara ◽  
Ginger Beau Langbroek ◽  
Chantal M. A. M. van der Horst ◽  
Albert Wolkerstorfer ◽  
Sophie E. R. Horbach ◽  
...  
Keyword(s):  
Systematic Review ◽  
Head And Neck ◽  
Neck Region ◽  
Therapeutic Strategies ◽  
Head And Neck Region ◽  
Meta Analyses

scholarly journals Kimura disease: a rare cause of a recurrent cheek mass in a Jamaican man

2021 ◽  
Vol 2021 (4) ◽  
Author(s):  
Geoffrey Williams ◽  
Carlos Neblett ◽  
Jade Arscott ◽  
Sheena McLean ◽  
Shereika Warren ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Local Recurrence ◽  
Head And Neck ◽  
African Descent ◽  
Young Men ◽  
Neck Region ◽  
Serum Immunoglobulin ◽  
Western World ◽  
Kimura Disease ◽  
Head And Neck Region

Abstract Kimura disease (KD) is a chronic, inflammatory, benign disorder endemic to Asia that typically manifests as a triad of painless masses in the head and neck region, elevated eosinophils and serum immunoglobulin. It usually affects young men in their second and third decades of life and is rarely seen outside of the orient. This is a report of a case of KD in a young man of African descent who presented with a cheek mass. KD was not included in our differential diagnosis, and this report highlights the need to consider this entity, which can be easily missed due to its rarity in the Western world. There is no cure for the disease, and management includes medical and surgical modalities, but local recurrence or relapse is not uncommon.

scholarly journals Extranodal lymphoma of the head and neck: a pictorial essay

2019 ◽  
Vol 52 (4) ◽  
pp. 268-271
Author(s):  
Pinar Gulmez Cakmak ◽  
Gülsüm Akgün Çağlayan ◽  
Furkan Ufuk
Keyword(s):  
Lymph Nodes ◽  
Head And Neck ◽  
Neck Region ◽  
Extranodal Lymphoma ◽  
Imaging Findings ◽  
Head And Neck Region ◽  
Radiological Features ◽  
Extranodal Site ◽  
Pictorial Essay

Abstract Primary extranodal lymphoma is defined as a lymphoma at a solitary extranodal site, with or without involvement of the lymph nodes. The clinical and radiological features of extranodal lymphoma have been documented in recent studies. In this pictorial essay, we reviewed imaging findings of extranodal lymphoma in the head and neck region.

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