Nearly silent pituitary adenoma presenting as blood-tinged sputum

2003 ◽  
Vol 129 (2) ◽  
pp. P265-P266
Author(s):  
A Yeh
Keyword(s):  
Pituitary Adenoma ◽  
Silent Pituitary Adenoma

Collision Tumors of the Sella: Craniopharyngioma and Silent Pituitary Adenoma Subtype 3: Case Report

2009 ◽  
Vol 20 (1) ◽  
pp. 50-55 ◽  
Author(s):  
Olga Moshkin ◽  
Bernd W. Scheithauer ◽  
Luis V. Syro ◽  
Alejandro Velasquez ◽  
Eva Horvath ◽  
...  
Keyword(s):  
Case Report ◽  
Pituitary Adenoma ◽  
Collision Tumors ◽  
Silent Pituitary Adenoma ◽  
Subtype 3

scholarly journals The Importance of Immunohistochemical Analysis in Silent Pituitary Adenoma

Medicinus ◽  
2018 ◽  
Vol 6 (3) ◽  
Author(s):  
Ivan William Harsono ◽  
Nathania Victoria Stevina ◽  
Vivien Puspitasari ◽  
Julius July
Keyword(s):  
Pituitary Adenoma ◽  
Immunohistochemical Analysis ◽  
Mass Effect ◽  
Visual Disturbance ◽  
Neurological Deficits ◽  
Parasellar Region ◽  
Benign Nature ◽  
Silent Pituitary Adenoma ◽  
Sinus Cavernosus ◽  
Benign Course

Pituitary adenoma contributes to 15% of all intracranial neoplasm. It is usually following benign course and some of them are silent (asymptomatic clinically, but hormone-secreting). Silent adenoma usually found incidentally or when the patients show mass effect (neurological deficits). Many of histologically aggressive silent adenoma subtypes are associated with invasiveness, recurrence and progression to clinically functioning adenomas. Aggressive silent adenoma radiologically tends to invade in downward direction, invading bone, sinus cavernosus, parasellar region. The nature of aggressive silent adenoma subtypes is differing in nature compared to benign nature of pituitary adenoma and should be confirmed immunohistochemically to determine the prognosis and anticipate the risk of recurrence or progression. The case illustration show a real case of 46 years old female progressive headache and visual disturbance diagnosed with non-functional pituitary macroadenoma but positive for more than one immunochemistry biomarker (plurihormonal aggressive silent adenoma).

Apoplexy of a Silent Pituitary Adenoma as the Only Presentation of a NovelAIPMutation in a Greek Family with Familial Isolated Pituitary Adenoma

2011 ◽  
pp. P1-437-P1-437
Author(s):  
Paraskevi Xekouki ◽  
Alex Mastroyannis ◽  
Charalambos Lysikatos ◽  
Nicholas Patronas ◽  
George P Chrousos ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Silent Pituitary Adenoma

Association of pituitary adenoma with neuronal christoma: A TEM study

1994 ◽  
Vol 52 ◽  
pp. 232-233
Author(s):  
Eva Horvath ◽  
Kalman Kovacs ◽  
B. W. Scheithauer ◽  
R. V. Lloyd ◽  
H. S. Smyth
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenoma ◽  
Pituitary Tumor ◽  
Nervous Tissue ◽  
Alternative Explanation ◽  
Growth Hormone Releasing Hormone ◽  
Cell Hyperplasia ◽  
Releasing Hormone ◽  
Secretory Neurons

The association of a pituitary adenoma with nervous tissue consisting of neuron-like cells and neuropil is a rare abnormality. In the majority of cases, the pituitary tumor is a chromophobic adenoma, accompanied by acromegaly. Histology reveals widely variable proportions of endocrine and nervous tissue in alternating or intermingled patterns. The lesion is perceived as a composite one consisting of two histogenetically distinct parts. It has been suggested that the neuronal component, morphologically similar to secretory neurons of the hypothalamus, may initiate adenoma formation by releasing stimulatory substances. Immunoreactivity for growth hormone releasing hormone (GRH) in the neuronal component of some cases supported this view, whereas other findings such as consistent lack of growth hormone (GH) cell hyperplasia in the lesions called for alternative explanation.Fifteen tumors consisting of a pituitary adenoma and a neuronal component have been collected over a 20 yr. period. Acromegaly was present in 11 patients, was equivocal in one, and absent in 3.

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