Nasal Septal Perforation and Carotid Cavernous Aneurysm: Unusual                Manifestations of Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a multisystem collagen vascular disorder defined by its clinical features and the presence of antibodies in the blood directed against one or more cell nuclei components. Typically, SLE affects the head and neck in the form of cutaneous malar erythema and oropharyngeal mucosal ulcerations. The uncommon findings of nasal septal perforations and restrictive central nervous system (CNS) aneurysmal formation as initial manifestations of SLE are detailed in this case report.

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Asymptomatic Nasal Septal Perforations in Systemic Lupus Erythematosus

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348948008900119 ◽

1980 ◽

Vol 89 (1) ◽

pp. 78-80 ◽

Cited By ~ 9

Author(s):

David Reiter ◽

Allen R. Myers

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Common Phenomenon ◽

Septal Perforation ◽

Systemic Lupus ◽

Clinical Correlates ◽

Nasal Septal Perforation ◽

Diagnostic Criterion ◽

Septal Perforations

Nasal septal perforation has been considered a diagnostic criterion for systemic lupus erythematosus since 1971. However, little has been published in the otorhinolaryngologic literature regarding this lesion. We report six patients having asymptomatic anteroinferior nasal septal perforations and symptomatic lupus. No obvious clinical correlates were found. We support the hypothesis that nasal septal perforation in systemic lupus erythematosus is a common phenomenon, and attribute its infrequent detection to the asymptomatic nature of the lesion in this setting.

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Autoantibodies in Neuropsychiatric Systemic Lupus Erythematosus (NPSLE): Can They Be Used as Biomarkers for the Differential Diagnosis of This Disease?

Clinical Reviews in Allergy & Immunology ◽

10.1007/s12016-021-08865-2 ◽

2021 ◽

Author(s):

Elias Manca

Keyword(s):

Systemic Lupus Erythematosus ◽

Central Nervous System ◽

Nervous System ◽

Differential Diagnosis ◽

Human Body ◽

Lupus Erythematosus ◽

Neuropsychiatric Symptoms ◽

Systemic Lupus ◽

Neuropsychiatric Systemic Lupus Erythematosus ◽

The Central Nervous System

AbstractSystemic lupus erythematosus is a complex immunological disease where both environmental factors and genetic predisposition lead to the dysregulation of important immune mechanisms. Eventually, the combination of these factors leads to the production of self-reactive antibodies that can target any organ or tissue of the human body. Autoantibodies can form immune complexes responsible for both the organ damage and the most severe complications. Involvement of the central nervous system defines a subcategory of the disease, generally known with the denomination of neuropsychiatric systemic lupus erythematosus. Neuropsychiatric symptoms can range from relatively mild manifestations, such as headache, to more severe complications, such as psychosis. The evaluation of the presence of the autoantibodies in the serum of these patients is the most helpful diagnostic tool for the assessment of the disease. The scientific progresses achieved in the last decades helped researchers and physicians to discover some of autoepitopes targeted by the autoantibodies, although the majority of them have not been identified yet. Additionally, the central nervous system is full of epitopes that cannot be found elsewhere in the human body, for this reason, autoantibodies that selectively target these epitopes might be used for the differential diagnosis between patients with and without the neuropsychiatric symptoms. In this review, the most relevant data is reported with regard to mechanisms implicated in the production of autoantibodies and the most important autoantibodies found among patients with systemic lupus erythematosus with and without the neuropsychiatric manifestations.

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