Heat shock protein and p53 expression in head and neck squamous cell carcinoma☆☆☆★

1998 ◽  
Vol 118 (5) ◽  
pp. 610-615 ◽  
Author(s):  
REGINA GANDOUR-EDWARDS ◽  
BRUCE J. TROCK ◽  
PAUL GUMERLOCK ◽  
PAUL J. DONALD
Keyword(s):  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
P53 Expression

scholarly journals Potent Activity of a Novel Dimeric Heat Shock Protein 90 Inhibitor against Head and Neck Squamous Cell Carcinoma In vitro and In vivo

2005 ◽  
Vol 11 (10) ◽  
pp. 3889-3896 ◽  
Author(s):  
Xiaoying Yin ◽  
Hong Zhang ◽  
Francis Burrows ◽  
Lin Zhang ◽  
Carol G. Shores
Keyword(s):  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Heat Shock Protein 90 ◽  
Neck Squamous Cell Carcinoma

scholarly journals Emphasizing on heat shock protein 90′s utility in head and neck squamous cell carcinoma treatment

2013 ◽  
Vol 9 (4) ◽  
pp. 583 ◽  
Author(s):  
Samapika Routray ◽  
Aparajita Sunkavalli ◽  
Niharika Swain ◽  
AkhilA Shankar
Keyword(s):  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Heat Shock Protein 90 ◽  
Neck Squamous Cell Carcinoma

Abstract 2770: Antitumor activity of heat shock protein 90 (HSP90) inhibitor AT13387 in head and neck squamous cell carcinoma

2012 ◽  
Author(s):  
Kristy Truong ◽  
Christopher Gouveia ◽  
Jamie Coupar ◽  
Tomoko Smyth ◽  
John Lyons ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Antitumor Activity ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Heat Shock Protein 90 ◽  
Hsp90 Inhibitor ◽  
Neck Squamous Cell Carcinoma

Heat Shock Protein and p53 Expression in Head and Neck Squamous Cell Carcinoma

1998 ◽  
Vol 118 (5) ◽  
pp. 610-624 ◽  
Author(s):  
Regina Gandour-Edwards ◽  
Bruce J. Trock ◽  
Paul Gumerlock ◽  
Paul J. Donald
Keyword(s):  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Primary Tumor Site ◽  
Shock Proteins

BACKGROUND: Heat shock proteins have been associated with the mutant form of the tumor suppressor gene, TP53, and with resistance to cancer chemotherapy. METHODS: Archival tissues from 50 patients with head and neck squamous cell carcinoma who received primary surgical resection were examined for p53, HSP27, and HSP70 by immunohistochemistry and correlated with tumor stage, grade, and 5-year survival (alive or deceased). RESULTS: Both heat shock proteins were strongly expressed in normal mucosa and in small (T1 and T2) tumors. Thirty (60%) of tumors were positive for p53, 43 (86%) for HSP27, and 34 (68%) for HSP70, with no association between p53 and heat shock protein expression. Twenty-five patients were alive (4 with disease), and 25 patients were deceased (9 from other causes). p53 Protein overexpression correlated with low-grade tumors. Only primary tumor site (i.e., oral cavity > larynx > oropharynx/base of tongue) and N stage were significantly associated with survival. CONCLUSIONS: Heat shock proteins are expressed in normal upper respiratory tract squamous mucosa, and their role in carcinoma remains unclear. None of the markers, p53, HSP27, or HSP70, demonstrated prognostic significance for 5-year survival. We confirm the recognized association of cervical lymph node metastases with decreased survival. (Otolaryngol Head Neck Surg 1998;118:610–5.)

scholarly journals Heat Shock Protein 27 as a New Therapeutic Target for Radiation Sensitization of Head and Neck Squamous Cell Carcinoma

2009 ◽  
Vol 17 (8) ◽  
pp. 1387-1394 ◽  
Author(s):  
Elie Hadchity ◽  
Marie-Thérèse Aloy ◽  
Christian Paulin ◽  
Emma Armandy ◽  
Emmanuel Watkin ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Therapeutic Target ◽  
Heat Shock Protein 27 ◽  
Neck Squamous Cell Carcinoma ◽  
Radiation Sensitization

scholarly journals Novel C-Terminal Heat Shock Protein 90 Inhibitors (KU711 and Ku757) Are Effective in Targeting Head and Neck Squamous Cell Carcinoma Cancer Stem cells

Neoplasia ◽  
2017 ◽  
Vol 19 (12) ◽  
pp. 1003-1011 ◽  
Author(s):  
C. Subramanian ◽  
K.J. Kovatch ◽  
M.W. Sim ◽  
G. Wang ◽  
M.E. Prince ◽  
...  
Keyword(s):  
Stem Cells ◽  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Cancer Stem Cells ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Heat Shock Protein 90 ◽  
Neck Squamous Cell Carcinoma

Hubungan ekspresi p53, Bcl-2, c-Myc dan MMP-9 dengan gambaran klinikopatologi karsinoma sel skuamosa kepala-leher

2016 ◽  
Vol 46 (1) ◽  
pp. 53
Author(s):  
Azwar Azwar ◽  
Sofia Mubarika ◽  
Agus Surono
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Tumor Location ◽  
Neck Squamous Cell Carcinoma ◽  
Second Primary ◽  
Cross Sectional ◽  
P53 Expression ◽  
Local Metastasis

Latar belakang: Karsinoma sel skuamosa kepala dan leher merupakan salah satu kanker terseringdi seluruh dunia. Pendekatan pengobatan agresif dan multidisiplin telah dilakukan, namun belum adapeningkatan yang signifikan dalam kelangsungan hidup 5 tahun, selama 20 tahun terakhir. Kegagalanpengobatan terjadi dalam bentuk kekambuhan lokoregional, metastasis jauh, dan/atau tumor primer kedua.Berbagai penanda molekular tumor telah diteliti untuk mengetahui potensinya dalam memprediksi hasilpenyakit atau respon terhadap terapi.Tujuan: Mengetahui hubungan ekspresi protein p53, Bcl-2, c-Myc,dan MMP-9 berdasarkan gambaran klinikopatologis karsinoma sel skuamosa kepala dan leher di RumahSakit dr. Zainoel Abidin.Metode: Studi menggunakan desain cross sectional. Sampel terdiri dari 60blok parafin karsinoma sel skuamosa kepala dan leher. Prosedur pewarnaan imunohistokimia dilakukandengan menggunakan antibodi monoklonal terhadap p53, Bcl-2, c-Myc, dan MMP-9. Ekspresi proteinp53, Bcl-2, c-Myc, dan MMP-9 dianalisis secara imunohistokimia pada karsinoma sel skuamosa kepaladan leher kemudian hasilnya dihubungkan dengan parameter klinikopatologis seperti usia, jenis kelamin,lokasi tumor, diferensiasi tumor, metastasis kelenjar getah bening dan stadium tumor, kemudian dianalisisstatistik dengan Chi square.Hasil: Hasil penelitian menunjukkan terdapat hubungan bermakna tingkatekspresi p53 dengan metastasis lokal (p=0,021) dan ada hubungan bermakna tingkat ekspresi MMP-9dengan lokasi tumor (p=0,026). Tidak terdapat hubungan ekspresi p53, Bcl-2, cMyc, dan MMP-9 terhadapusia, jenis kelamin, stadium tumor, diferensiasi histologi, tingkat T, N, dan metastasis jauh.Kesimpulan:Ada hubungan ekpresi p53 dengan metastasis kelenjar limfe regional dan ekspresi MMP-9 dengan lokasitumor pada karsinoma sel skuamosa kepala dan leher. Kata kunci: Karsinoma sel skuamosa kepala dan leher, p53, Bcl-2, c-Myc, MMP-9 ABSTRACTBackground: Head and neck squamous cell carcinoma (HNSCC) is one of the most commoncancers world wide. Although aggressive and multidisciplinary approach to the treatment has been done,there is no significant improvement in 5-year survival in the last 20 years. Treatment failure occurredin the form of locoregional recurrence, distant metastasis, and/or a second primary tumor. A variety oftumor molecular markers have been studied to determine their potential in predicting disease outcome orresponse to the therapy. Purpose: To investigate correlation p53, Bcl-2, c-Myc, and MMP-9 expressionto clinicopathologic parameter in head and neck squamous cell carcinoma patient in dr. Zainoel Abidinhospital. Methods: Cross sectional design study. The sample was consisted of 60 paraffin blocks ofhead and neck squamous cell carcinoma. Procedure of immunohistochemical staining used monoclonalantibodies against p53, Bcl-2, c-Myc, and MMP-9. Expression of p53 protein, Bcl-2, c-Myc, and MMP-9were analyzed by immunohistochemistry in head and neck squamous cell carcinoma. Then, the results were linked to clinicopathologic parameters such as age, sex, tumor location, tumor differentiation,lymph node metastasis and tumor stage, and statistically analyzed with Chi square. Results: The resultsshowed there were significant correlation between p53 expression level with local metastasis (p=0,021)and significant correlation of MMP-9 expression levels with tumor location (p=0,026). There were norelationship of p53, Bcl-2, cMyc and MMP-9 expressions based on age, sex, stage tumor, histologicdifferentiation, level of T, N, and distant metastases. Conclusion: There were relationships between p53expression with local metastasis and MMP-9 expression with tumor location in head and neck squamouscell carcinoma. Keywords: Head and neck squamous cell carcinoma, p53, Bcl-2, c-Myc, MMP-9

scholarly journals p53 Expression: Predicting Recurrence and Second Primary Tumors in Head and Neck Squamous Cell Carcinoma

1996 ◽  
Vol 88 (8) ◽  
pp. 519-529 ◽  
Author(s):  
D. M. Shin ◽  
J. S. Lee ◽  
S. M. Lippman ◽  
J. J. Lee ◽  
Z. N. Tu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Second Primary ◽  
Primary Tumors ◽  
P53 Expression ◽  
Second Primary Tumors

Prognostic Value of Microvessel Density and p53 Expression on the Locoregional Metastasis and Survival of the Patients With Head and Neck Squamous Cell Carcinoma

2013 ◽  
Vol 21 (5) ◽  
pp. 444-451 ◽  
Author(s):  
Marcos Vinícius M. de Oliveira ◽  
Érika P. Pereira Gomes ◽  
Camila S. Pereira ◽  
Ludmilla R. de Souza ◽  
Lucas O. Barros ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Microvessel Density ◽  
Prognostic Value ◽  
Neck Squamous Cell Carcinoma ◽  
P53 Expression
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