Abstract 2770: Antitumor activity of heat shock protein 90 (HSP90) inhibitor AT13387 in head and neck squamous cell carcinoma

2012 ◽  
Author(s):  
Kristy Truong ◽  
Christopher Gouveia ◽  
Jamie Coupar ◽  
Tomoko Smyth ◽  
John Lyons ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Antitumor Activity ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Heat Shock Protein 90 ◽  
Hsp90 Inhibitor ◽  
Neck Squamous Cell Carcinoma

scholarly journals Potent Activity of a Novel Dimeric Heat Shock Protein 90 Inhibitor against Head and Neck Squamous Cell Carcinoma In vitro and In vivo

2005 ◽  
Vol 11 (10) ◽  
pp. 3889-3896 ◽  
Author(s):  
Xiaoying Yin ◽  
Hong Zhang ◽  
Francis Burrows ◽  
Lin Zhang ◽  
Carol G. Shores
Keyword(s):  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Heat Shock Protein 90 ◽  
Neck Squamous Cell Carcinoma

scholarly journals Emphasizing on heat shock protein 90′s utility in head and neck squamous cell carcinoma treatment

2013 ◽  
Vol 9 (4) ◽  
pp. 583 ◽  
Author(s):  
Samapika Routray ◽  
Aparajita Sunkavalli ◽  
Niharika Swain ◽  
AkhilA Shankar
Keyword(s):  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Heat Shock Protein 90 ◽  
Neck Squamous Cell Carcinoma

scholarly journals Novel C-Terminal Heat Shock Protein 90 Inhibitors (KU711 and Ku757) Are Effective in Targeting Head and Neck Squamous Cell Carcinoma Cancer Stem cells

Neoplasia ◽  
2017 ◽  
Vol 19 (12) ◽  
pp. 1003-1011 ◽  
Author(s):  
C. Subramanian ◽  
K.J. Kovatch ◽  
M.W. Sim ◽  
G. Wang ◽  
M.E. Prince ◽  
...  
Keyword(s):  
Stem Cells ◽  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Cancer Stem Cells ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Heat Shock Protein 90 ◽  
Neck Squamous Cell Carcinoma

Heat Shock Protein and p53 Expression in Head and Neck Squamous Cell Carcinoma

1998 ◽  
Vol 118 (5) ◽  
pp. 610-624 ◽  
Author(s):  
Regina Gandour-Edwards ◽  
Bruce J. Trock ◽  
Paul Gumerlock ◽  
Paul J. Donald
Keyword(s):  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Primary Tumor Site ◽  
Shock Proteins

BACKGROUND: Heat shock proteins have been associated with the mutant form of the tumor suppressor gene, TP53, and with resistance to cancer chemotherapy. METHODS: Archival tissues from 50 patients with head and neck squamous cell carcinoma who received primary surgical resection were examined for p53, HSP27, and HSP70 by immunohistochemistry and correlated with tumor stage, grade, and 5-year survival (alive or deceased). RESULTS: Both heat shock proteins were strongly expressed in normal mucosa and in small (T1 and T2) tumors. Thirty (60%) of tumors were positive for p53, 43 (86%) for HSP27, and 34 (68%) for HSP70, with no association between p53 and heat shock protein expression. Twenty-five patients were alive (4 with disease), and 25 patients were deceased (9 from other causes). p53 Protein overexpression correlated with low-grade tumors. Only primary tumor site (i.e., oral cavity > larynx > oropharynx/base of tongue) and N stage were significantly associated with survival. CONCLUSIONS: Heat shock proteins are expressed in normal upper respiratory tract squamous mucosa, and their role in carcinoma remains unclear. None of the markers, p53, HSP27, or HSP70, demonstrated prognostic significance for 5-year survival. We confirm the recognized association of cervical lymph node metastases with decreased survival. (Otolaryngol Head Neck Surg 1998;118:610–5.)

scholarly journals Heat Shock Protein 27 as a New Therapeutic Target for Radiation Sensitization of Head and Neck Squamous Cell Carcinoma

2009 ◽  
Vol 17 (8) ◽  
pp. 1387-1394 ◽  
Author(s):  
Elie Hadchity ◽  
Marie-Thérèse Aloy ◽  
Christian Paulin ◽  
Emma Armandy ◽  
Emmanuel Watkin ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Therapeutic Target ◽  
Heat Shock Protein 27 ◽  
Neck Squamous Cell Carcinoma ◽  
Radiation Sensitization

Heat shock protein and p53 expression in head and neck squamous cell carcinoma☆☆☆★

1998 ◽  
Vol 118 (5) ◽  
pp. 610-615 ◽  
Author(s):  
REGINA GANDOUR-EDWARDS ◽  
BRUCE J. TROCK ◽  
PAUL GUMERLOCK ◽  
PAUL J. DONALD
Keyword(s):  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
P53 Expression

Heat shock protein 90 as a molecular target for therapy in oral squamous cell carcinoma: Inhibitory effects of 17‑DMAG and ganetespib on tumor cells

2020 ◽  
Vol 45 (2) ◽  
pp. 448-458
Author(s):  
Naoki Shiraishi ◽  
Takeshi Onda ◽  
Kamichika Hayashi ◽  
Kaoru Onidani ◽  
Katsuhito Watanabe ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Heat Shock ◽  
Oral Squamous Cell Carcinoma ◽  
Heat Shock Protein ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Squamous Cell ◽  
Heat Shock Protein 90 ◽  
Molecular Target ◽  
Inhibitory Effects

Abstract 44: Synergistic antitumor activity of olaparib combined with AZD1775 in head and neck squamous cell carcinoma

2017 ◽  
Author(s):  
Hideaki Takahashi ◽  
Antje Lindemann ◽  
Ameeta A. Patel ◽  
Weiwei Liu ◽  
Noriaki Tanaka ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Antitumor Activity ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Synergistic Antitumor Activity
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