Mechanism of Action of Nonsteroidal Anti-Inflammatory Drugs

2000 ◽  
Vol 30 (4) ◽  
pp. 773-781 ◽  
Author(s):  
Alexander Livingston
Keyword(s):  
Mechanism Of Action ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Mechanism of Action of Nonsteroidal Anti-inflammatory Drugs

1998 ◽  
Vol 16 (7) ◽  
pp. 509-527 ◽  
Author(s):  
Tony L. Yaksh ◽  
David M. Dirig ◽  
Annika B. Malmberg
Keyword(s):  
Mechanism Of Action ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Non-steroidal anti-flammatory drugs in domestic animals: I. Their classification, mechanism of action and pharmacological effects

1991 ◽  
Vol 62 (1) ◽  
pp. 35-38 ◽  
Author(s):  
G. E. Swan
Keyword(s):  
Mechanism Of Action ◽  
Domestic Animals ◽  
Pharmacological Effects ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Chemical Groups

A large number of non-steroidal anti-inflammatory drugs, of different chemical groups are available for veterinary use. These drugs act mainly by inhibiting the. formation of endoperoxides (prostaglandins and thromboxanes) through the inhibition of cyclo-oxygenase in the eicosanoid pathway. A wide range of pharmacological effects, including analgesic, antipyretic and anti-inflammatory effects occur as a result of this inhibition. The classification, mechanism of action and pharmacological effects of these drugs are reviewed.

Non-steroidal anti-inflammatory drugs inhibit bone healing: A review

2010 ◽  
Vol 23 (06) ◽  
pp. 385-392 ◽  
Author(s):  
S. Barry
Keyword(s):  
Animal Models ◽  
Heterotopic Ossification ◽  
Mechanism Of Action ◽  
Bone Healing ◽  
Clinical Importance ◽  
Human Medicine ◽  
Experimental Animal Models ◽  
Domestic Species ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

SummaryThe ability of non-steroidal anti-inflammatory drugs (NSAID) to inhibit bone healing has been established in experimental animal models using mice, rats, and rabbits. The mechanism of action is largely unknown but stems from prostaglandin inhibition and is likely multifactorial. In human medicine NSAID are known to prevent heterotopic ossification, however the clinical importance of their effects on bone healing remains controversial. Although a small handful of reports suggest that NSAID suppress bone healing in dogs and horses, there is little published information to direct veterinary practice in domestic species.

Potential complications of nonsteroidal anti-inflammatory drug therapy

1989 ◽  
Vol 79 (12) ◽  
pp. 605-614
Author(s):  
GD Corrigan ◽  
L Pantig-Felix ◽  
IO Kanat
Keyword(s):  
Health Care ◽  
Patient Satisfaction ◽  
Drug Therapy ◽  
Side Effects ◽  
Mechanism Of Action ◽  
Drug Class ◽  
Inflammatory Drug ◽  
The Us ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Since indomethacin was first marketed, some 40 years ago, the class of nonsteroidal anti-inflammatory drugs has grown larger than any other drug class in history. At present, there are at least 25 such drugs being used in the US and abroad, both clinically and in research. Despite their widespread use, their implications to health care are just beginning to be understood. The authors review updated theories on the mechanism of action, side effects, and drug interactions of nonsteroidal anti-inflammatory drug therapy. Proposed guidelines for monitoring their use are given. A more thorough understanding of the risks-to-benefits ratio is provided in an effort to achieve maximum patient satisfaction and safety.

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