Potential complications of nonsteroidal anti-inflammatory drug therapy

1989 ◽  
Vol 79 (12) ◽  
pp. 605-614
Author(s):  
GD Corrigan ◽  
L Pantig-Felix ◽  
IO Kanat
Keyword(s):  
Health Care ◽  
Patient Satisfaction ◽  
Drug Therapy ◽  
Side Effects ◽  
Mechanism Of Action ◽  
Drug Class ◽  
Inflammatory Drug ◽  
The Us ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Since indomethacin was first marketed, some 40 years ago, the class of nonsteroidal anti-inflammatory drugs has grown larger than any other drug class in history. At present, there are at least 25 such drugs being used in the US and abroad, both clinically and in research. Despite their widespread use, their implications to health care are just beginning to be understood. The authors review updated theories on the mechanism of action, side effects, and drug interactions of nonsteroidal anti-inflammatory drug therapy. Proposed guidelines for monitoring their use are given. A more thorough understanding of the risks-to-benefits ratio is provided in an effort to achieve maximum patient satisfaction and safety.

Reducing pain in certain forms of obstetric pathology: nonsteroidal anti-inflammatory drugs (Сlinical lecture)

2017 ◽  
pp. 9-14
Author(s):  
L. Nazarenko ◽  
Keyword(s):  
Preterm Birth ◽  
Side Effects ◽  
Key Words ◽  
Clinical Efficacy ◽  
Premature Birth ◽  
Pain Syndrome ◽  
Inflammatory Drug ◽  
Threatened Abortion ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

The article discusses the pathogenetic basis for the use of non-steroidal anti-inflammatory drugs (NSPVP) in obstetric practice for the treatment of pain syndrome in women with threatened abortion and pathological preliminary period. Provided with modern views on the mechanisms of analgesic clinical efficacy, side effects NSPVP. Provides information about the place of NSPVP during pregnancy, the risks to the fetus, the positive aspects in the conduct of women at risk of preterm birth, the pathological preliminary period. Key words: nonsteroidal anti-inflammatory drug, pain, premature birth, preliminary period.

scholarly journals Nimesulide Mechanism of Action: Focus on Histamine

Doctor Ru ◽  
2021 ◽  
Vol 20 (4) ◽  
pp. 67-70
Author(s):  
G.Yu. Knorring ◽  
◽  
Keyword(s):  
Side Effects ◽  
Mechanism Of Action ◽  
Low Risk ◽  
Histamine Secretion ◽  
Interesting Effect ◽  
Key Points ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Available Information ◽  
Inflammatory Effect

Objective of the Review: To analyse available information on the nimesulide mechanism of action, namely of recent studies of COXindependent effects of nimesulide, affecting primarily histamine-mediated reactions. Key Points. Fast and lasting anti-inflammatory and analgetic effects of nimesulide are a result of a number of actions not associated with cyclooxygenase 2 inhibition. Of utmost interest are effects associated with suppression of immune and non-immune histamine secretion. Conclusion. An interesting effect of nimesulide is an impact on histamine secretion; it explains more pronounced analgetic and anti-inflammatory effect of nimesulide and a low risk of respiratory and GIT side effects. Keywords: nonsteroidal anti-inflammatory drugs, cyclooxygenase, histamine, nimesulide.

Nonsteroidal Anti-Inflammatory Drug Therapy and Gastric Side Effects

Drugs ◽  
1990 ◽  
Vol 40 (Supplement 5) ◽  
pp. 16-24 ◽  
Author(s):  
P. Dandona ◽  
J.Y. Jeremy
Keyword(s):  
Drug Therapy ◽  
Side Effects ◽  
Inflammatory Drug ◽  
Anti Inflammatory

scholarly journals Non-Steroid Inflammation (Nsaid) Drug Selling Profile Based On Self-Medication Service at Mida Farma I Drugstore Gresik

2021 ◽  
Vol 1 (1) ◽  
pp. 24-29
Author(s):  
Helmi Hanifah ◽  
Pemta Tiadeka ◽  
Riskha Aulia
Keyword(s):  
Side Effects ◽  
Plasma Level ◽  
Data Collection ◽  
Maximum Plasma ◽  
Observational Method ◽  
Self Medication ◽  
Inflammatory Drug ◽  
Inflammatory Drugs ◽  
Cox 2 ◽  
Anti Inflammatory

This study aims to determine the profile of self-medication sales of non-steroidal anti-inflammatory drugs at Mida Farma I Drugstore Gresik. It is conducted by using the observational method with data collection and observation on the Non-Steroid Anti-Inflammatory Drug (NSAID) stock cards in February 2020 at Mida Farma I Drugstore Gresik. The results show that the highest sales profile is the non-selective group of 87.68%, then the second is the COX-2 selective group of 12.32%. The most sold drug is ibuprofen of 20% and the lowest sold one is Aspirin of 14%. The pharmacokinetics of ibuprofen are it absorbs very quickly through the stomach; has a maximum plasma level that has reached 1 to 2 hours; and has low side effects

Orthotic therapy in the management of osteoarthritis

1992 ◽  
Vol 82 (3) ◽  
pp. 136-139 ◽  
Author(s):  
JA Thompson ◽  
MB Jennings ◽  
W Hodge
Keyword(s):  
Drug Therapy ◽  
Pain Relief ◽  
Foot And Ankle ◽  
Inflammatory Drug ◽  
Treatment Regimens ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Term Management

The authors evaluate the use of orthoses as a primary therapeutic means in the long-term management of patients with osteoarthritis of the foot and ankle. A comparison of the amount of pain relief experienced by 64 subjects (mean age 63 years) with different treatment regimens for osteoarthritis was made to determine the role orthoses played in helping to reduce or eliminate pain. One hundred percent of the subjects wearing orthoses only for relief of pain had a statistically significant longer period of pain relief than those on nonsteroidal anti-inflammatory drugs. Fifty-five percent of the subjects using orthoses and nonsteroidal anti-inflammatory drug therapy also had a statistically significant longer period of pain relief than those receiving nonsteroidal anti-inflammatory drug therapy only.

Place of diclofenac in therapeutic standards in rheumatology

2021 ◽  
Vol 14 (3) ◽  
pp. 274-278
Author(s):  
Robert Rupiński ◽  
Jarosław Woroń
Keyword(s):  
Side Effects ◽  
Autoimmune Diseases ◽  
Clinical Experience ◽  
Inflammatory Pain ◽  
Individual Characteristics ◽  
Drug Selection ◽  
Inflammatory Drug ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
The Individual

Non-steroidal anti-inflammatory drugs (NSAIDs) are drugs that are difficult to replace in the treatment of inflammatory pain. Both the mechanisms involved in the development of inflammatory pain and the individual characteristics of each non-steroidal anti-inflammatory drugs currently allow for personalized drug selection in such a way as to escalate its effectiveness while minimizing the risk of side effects. Diclofenac is a non-steroidal anti-inflammatory drug with one of the longest clinical experience. Since the beginning of the 70s of the last century, it has become an important element of everyday rheumatological practice, used in both degenerative and autoimmune diseases.

General Practitioners' Evaluation of Side-Effects and Efficacy of Oxamethacin as Compared with Indomethacin

1980 ◽  
Vol 8 (2) ◽  
pp. 156-162 ◽  
Author(s):  
J Polderman ◽  
M Colon
Keyword(s):  
Clinical Trial ◽  
Drug Therapy ◽  
Side Effects ◽  
General Practitioners ◽  
Double Blind ◽  
Inflammatory Drug ◽  
Pathological Conditions ◽  
Maximum Duration ◽  
Double Blind Clinical Trial ◽  
Anti Inflammatory

Sixteen general practitioners conducted a multicentre double-blind clinical trial to compare oxamethacin (100 mg t.i.d.) with indomethacin (50 mg t.i.d.) for a maximum duration of 2 weeks. Each drug was administered to 339 patients suffering from various pathological conditions requiring a non steroidal anti-inflammatory drug. When focusing on patients without associated drug therapy, 126/250 patients (50%) presented a good response on inflammation under oxamethacin and 98/236 patients (42%) a good response under indomethacin (p < 10−2); 141/250 patients (56%) presented a good response on pain under oxamethacin and 117/236 (50%) under indomethacin (p<5.10−2). Side effects and complaints were reported by 34/250 patients (14%) under oxamethacin and by 67/236 (28%) under indomethacin (p < 5.10−5). Some patients stopped treatment because of side-effects: 14/250 (6%) under oxamethacin and 32/236 (14%) under indomethacin (p < 2.10−3).

Sign in / Sign up

Export Citation Format

Share Document