Is osteonecrosis of the femoral head avascular? Bone blood flow measurements after long-term treatment with corticosteroids

1. Glomerular filtration rate was determined from 51Cr—EDTA clearance in twenty hypertensive subjects treated with propranolol. 2. A significant mean decrease of 13% in the glomerular filtration rate was found during treatment, and an increase of the same order of magnitude after withdrawal of propranolol. 3. It is suggested that these changes are related to a reduction in the renal blood flow. 4. No significant changes were found in plasma volume.

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Considerations in use of microspheres for myocardial blood-flow measurements in long-term experiments on rats

Journal of Pharmacological Methods ◽

10.1016/0160-5402(88)90074-5 ◽

1988 ◽

Vol 20 (2) ◽

pp. 143-149 ◽

Cited By ~ 1

Author(s):

Oleg S. Medvedev ◽

Elena R. Martynova ◽

Renat S. Akchurin ◽

Vadim Y. Khalatov

Keyword(s):

Blood Flow ◽

Myocardial Blood Flow ◽

Flow Measurements ◽

Long Term Experiments ◽

Blood Flow Measurements

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Long term liver blood flow measurements in rats under physiological conditions

Pflügers Archiv - European Journal of Physiology ◽

10.1007/bf00586448 ◽

1971 ◽

Vol 323 (2) ◽

pp. 182-186 ◽

Cited By ~ 5

Author(s):

E. E. Ohnhaus ◽

E. Emons ◽

A. Breckenridge

Keyword(s):

Blood Flow ◽

Liver Blood Flow ◽

Flow Measurements ◽

Physiological Conditions ◽

Blood Flow Measurements

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Osteotomy for Osteonecrosis of the Femoral Head: Knowledge from Our Long-Term Treatment Experience at Kyushu University

Treatment of Osteoarthritic Change in the Hip ◽

10.1007/978-4-431-38200-3_10 ◽

2007 ◽

pp. 79-88

Author(s):

Seiya Jingushi

Keyword(s):

Femoral Head ◽

Term Treatment ◽

Treatment Experience ◽

Long Term Treatment

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Long-term treatment of osteoporosis with 24,25 dihydroxycholecalciferol

Acta Endocrinologica ◽

10.1530/acta.0.1010636 ◽

1982 ◽

Vol 101 (4) ◽

pp. 636-640 ◽

Cited By ~ 10

Author(s):

J. Reeve ◽

M. Tellez ◽

J. R. Green ◽

R. Hesp ◽

U. Elsasser ◽

...

Keyword(s):

Plasma Levels ◽

Calcium Absorption ◽

Statistical Significance ◽

Term Treatment ◽

Bone Blood Flow ◽

Treatment Of Osteoporosis ◽

Dihydroxyvitamin D ◽

Long Term Treatment ◽

Term Benefit

Abstract. Five patients with involutional osteoporosis were treated with 24,25 dihydroxycholecalciferol (24,25-(OH)2D3) for 6 months, in doses sufficient to double plasma levels at that time. Dietary calcium absorption transiently improved by nearly 2 mmol Ca per day at 2 weeks, but this effect was lost by 6 months. The calcium and phosphate balances followed the trends in calcium absorption. Only twenty-five dihydroxyvitamin D levels changed little. Histomorphometric and kinetic indices of new bone formation and bone blood flow remained stable but there was an increase in urine hydroxyproline at 6 months, which was of borderline statistical significance. Treatment at this dosage of 24,25(OH)2D3, which increased plasma levels within the physiological range, conferred no measurable long-term benefit on our patients. Larger doses, or combination therapy, may warrant further clinical evaluation in osteoporosis.

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