MON-LB272: A Randomized, Double-Blind, Parallel, Controlled and Multicenter Study to Assess the Efficacy and Safety of New Compound Amino Acid (19) N-L-Alanyl-L-Glutamine Injection in Postoperative Patients of Gastrointestinal Surgery with Total Parenteral Nutrition

2016 ◽  
Vol 35 ◽  
pp. S253
Author(s):  
J. Yu ◽  
G. Wu ◽  
B. Liang ◽  
Y. Tang ◽  
B. Wang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Parenteral Nutrition ◽  
Total Parenteral Nutrition ◽  
Multicenter Study ◽  
Gastrointestinal Surgery ◽  
Efficacy And Safety ◽  
Double Blind

scholarly journals Total parenteral nutrition-induced Wernicke’s encephalopathy after oncologic gastrointestinal surgery

Open Medicine ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. 709-713
Author(s):  
Piergiorgio Fedeli ◽  
Richard Justin Davies ◽  
Roberto Cirocchi ◽  
Georgi Popivanov ◽  
Paolo Bruzzone ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Total Parenteral Nutrition ◽  
Gastrointestinal Surgery ◽  
Vitamin B1 ◽  
Wernicke’S Encephalopathy ◽  
Wernicke's Encephalopathy ◽  
Vitamin Intake ◽  
Unbalanced Diet ◽  
Prolonged Hospital ◽  
Care Costs

AbstractCarl Wernicke described the disease bearing his name in 1881 and reported three cases characterized by the presence of mental confusion, ataxia, and ophthalmoplegia. Wernicke’s disease is mainly observed in alcoholic patients, due to decreased vitamin intake as a consequence of an unbalanced diet, and a reduction of absorption due to the effects of alcohol. Likewise, inadequate vitamin intake is prevalent in older patients. Wernicke’s encephalopathy due to inappropriate total parenteral nutrition (TPN) occurs infrequently; recently, there is an increase in the literature concerning Wernicke’s encephalopathy in patients after general and bariatric surgeries. We present two cases of Wernicke’s encephalopathy after oncologic gastrointestinal surgery by failure to administer vitamin B1 during TPN; to our knowledge, these are the first two cases of Wernicke’s encephalopathy after colorectal surgery for cancer. In our opinion, timely diagnosis and treatment are mandatory to avoid nonfunctional recovery and consequent malpractice legal actions as well as an increase in the health-care costs correlated with the prolonged hospital stay and with the nonfunctional recovery.

Perioperative Use of Total Parenteral Nutrition: Variations in Guidelines and Practice in Three Norwegian Hospitals

1995 ◽  
Vol 11 (4) ◽  
pp. 741-749 ◽  
Author(s):  
Marianne Mjaaland ◽  
Arthur Revhaug ◽  
Olav Helge Førde
Keyword(s):  
Retrospective Study ◽  
Parenteral Nutrition ◽  
Total Parenteral Nutrition ◽  
Gastrointestinal Surgery ◽  
Patient Characteristics ◽  
Substantial Part ◽  
Cross Sectional

AbstractIn a cross-sectional, retrospective study of 604 cases, variations among three Norwegian hospitals in use of perioperative parenteral nutrition (TPN) after gastrointestinal surgery was determined. Postoperative TPN rates were 25%, 34% (p =.05) and 56% (p <.0001). respectively. However, a substantial part of the variation was explained by differences in patient characteristics.

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