Changes in the transport kinetics of neutral amino acids across the blood-brain barrier in experimental hepatic encephalopathy

1985 ◽  
Vol 4 ◽  
pp. 97-102
Author(s):  
T JONUNG ◽  
P RIGOTTI ◽  
J JAMES ◽  
J FISCHER
Keyword(s):  
Amino Acids ◽  
Hepatic Encephalopathy ◽  
Blood Brain Barrier ◽  
Transport Kinetics ◽  
Brain Barrier ◽  
Neutral Amino Acids ◽  
Blood Brain ◽  
Kinetics Of ◽  
Experimental Hepatic Encephalopathy

scholarly journals Blood-brain barrier transport kinetics of NOTA-modified proteins: the somatropin case

2020 ◽  
Vol 64 (1) ◽  
Author(s):  
Nathalie Bracke ◽  
Yorick Janssens ◽  
Evelien Wynendaele ◽  
Liesa Tack ◽  
Alex Maes ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Transport Kinetics ◽  
Brain Barrier ◽  
Blood Brain ◽  
Modified Proteins ◽  
Kinetics Of

Transport of Neutral Amino Acids at the Blood-Brain Barrier

Pharmacology ◽  
1981 ◽  
Vol 22 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Howard James ◽  
Josef E. Fischer
Keyword(s):  
Amino Acids ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Neutral Amino Acids ◽  
Blood Brain

A reassessment of the blood-brain barrier transport of large neutral amino acids during acute systemic inflammation in humans

2017 ◽  
Vol 38 (4) ◽  
pp. 656-662 ◽  
Author(s):  
Rasmus H. Dahl ◽  
Ronan M. G. Berg ◽  
Sarah Taudorf ◽  
Damian M. Bailey ◽  
Carsten Lundby ◽  
...  
Keyword(s):  
Amino Acids ◽  
Blood Brain Barrier ◽  
Systemic Inflammation ◽  
Brain Barrier ◽  
Large Neutral Amino Acids ◽  
Neutral Amino Acids ◽  
Blood Brain

Blood-brain barrier transport kinetics of the neuromedin peptides NMU, NMN, NMB and NT

2016 ◽  
Vol 107 ◽  
pp. 460-470 ◽  
Author(s):  
Bert Gevaert ◽  
Evelien Wynendaele ◽  
Sofie Stalmans ◽  
Nathalie Bracke ◽  
Matthias D'Hondt ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Transport Kinetics ◽  
Brain Barrier ◽  
Blood Brain ◽  
Kinetics Of

Blood-brain barrier transport kinetics of the cyclic depsipeptide mycotoxins beauvericin and enniatins

2016 ◽  
Vol 258 ◽  
pp. 175-184 ◽  
Author(s):  
Lien Taevernier ◽  
Nathalie Bracke ◽  
Lieselotte Veryser ◽  
Evelien Wynendaele ◽  
Bert Gevaert ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Transport Kinetics ◽  
Brain Barrier ◽  
Cyclic Depsipeptide ◽  
Blood Brain ◽  
Kinetics Of

Regional Transport of Phenylalanine and Other Neutral Amino Acids Across the Blood-Brain Barrier

1988 ◽  
pp. 63-67 ◽  
Author(s):  
Richard A. Hawkins ◽  
Anke M. Mans ◽  
Julien F. Biebuyck
Keyword(s):  
Amino Acids ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Regional Transport ◽  
Neutral Amino Acids ◽  
Blood Brain

Na+-dependent transport of large neutral amino acids occurs at the abluminal membrane of the blood-brain barrier

2003 ◽  
Vol 285 (6) ◽  
pp. E1167-E1173 ◽  
Author(s):  
Robyn L. O'Kane ◽  
Richard A. Hawkins
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Blood Brain Barrier ◽  
Basement Membranes ◽  
Brain Barrier ◽  
Large Neutral Amino Acid ◽  
Large Neutral Amino Acids ◽  
Neutral Amino Acids ◽  
Blood Brain ◽  
Dependent Transport

Several Na+-dependent carriers of amino acids exist on the abluminal membrane of the blood-brain barrier (BBB). These Na+-dependent carriers are in a position to transfer amino acids from the extracellular fluid of brain to the endothelial cells and thence to the circulation. To date, carriers have been found that may remove nonessential, nitrogen-rich, or acidic (excitatory) amino acids, all of which may be detrimental to brain function. We describe here Na+-dependent transport of large neutral amino acids across the abluminal membrane of the BBB that cannot be ascribed to currently known systems. Fresh brains, from cows killed for food, were used. Microvessels were isolated, and contaminating fragments of basement membranes, astrocyte fragments, and pericytes were removed. Abluminal-enriched membrane fractions from these microvessels were prepared. Transport was Na+dependent, voltage sensitive, and inhibited by 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid, a particular inhibitor of the facilitative large neutral amino acid transporter 1 (LAT1) system. The carrier has a high affinity for leucine ( Km21 ± 7 μM) and is inhibited by other neutral amino acids, including glutamine, histidine, methionine, phenylalanine, serine, threonine, tryptophan, and tyrosine. Other established neutral amino acids may enter the brain by way of LAT1-type facilitative transport. The presence of a Na+-dependent carrier on the abluminal membrane capable of removing large neutral amino acids, most of which are essential, from brain indicates a more complex situation that has implications for the control of essential amino acid content of brain.

Passage of amino acids and glucose across the blood-brain barrier in patients with hepatic encephalopathy

Hepatology ◽  
1993 ◽  
Vol 17 (6) ◽  
pp. 987-992 ◽  
Author(s):  
Gitte M. Knudsen ◽  
Jes Schmidt ◽  
Thomas Almdal ◽  
Olaf B. Paulson ◽  
Hendrik Vilstrup
Keyword(s):  
Amino Acids ◽  
Hepatic Encephalopathy ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain
Sign in / Sign up

Export Citation Format

Share Document