Creature resembling a giant paper clip lived 200 years

2020 ◽  
Vol 248 (3308) ◽  
pp. 21
Author(s):  
Colin Barras
Keyword(s):  
Paper Clip

The JenaValve pericardial transcatheter aortic valve replacement system to treat aortic valve disease

2021 ◽  
Author(s):  
Thomas Poschner ◽  
Paul Werner ◽  
Alfred Kocher ◽  
Guenther Laufer ◽  
Francesco Musumeci ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Replacement ◽  
Valve Replacement ◽  
Transcatheter Aortic Valve Replacement ◽  
Pacemaker Implantation ◽  
Limited Data ◽  
Transcatheter Aortic Valve ◽  
Paper Clip ◽  
Replacement System

Transcatheter aortic valve replacement is a valuable alternative technique to surgery and the spectrum of therapy continues to evolve. The JenaValve Pericaridal transcatheter aortic valve replacement System allows prosthesis fixation in a native, noncalcified aortic annulus with a unique paper clip-like anchorage mechanism. The low rate of paravalvular leakage and permanent pacemaker implantation emphasizes the further widespread use of the JenaValve – despite the limited data available. In May 2021, a CE mark for the transfemoral implantation in both aortic regurgitation and aortic stenosis was granted. However, no data have been published so far. The ongoing ALIGN trials are expected to provide the pending long-term data.

Paper Clip Microretractor

2008 ◽  
Vol 25 (04) ◽  
pp. 273-273 ◽  
Author(s):  
Pietro di Summa ◽  
Wassim Raffoul ◽  
Daniel Kalbermatten
Keyword(s):  
Paper Clip

The paper clip mole - An undergraduate experiment

1975 ◽  
Vol 52 (6) ◽  
pp. 386 ◽  
Author(s):  
T. Cassen
Keyword(s):  
Paper Clip

scholarly journals The molecular mechanism of Hsp90-induced oligomerization of Tau

2019 ◽  
Author(s):  
Sabrina Weickert ◽  
Magdalena Wawrzyniuk ◽  
Laura John ◽  
Stefan G. D. Rüdiger ◽  
Malte Drescher
Keyword(s):  
Structural Information ◽  
Conformational Ensemble ◽  
Toxic Agent ◽  
Paramagnetic Resonance ◽  
Biologically Relevant ◽  
Intrinsically Disordered ◽  
Tau Oligomers ◽  
Paper Clip ◽  
Repeat Domain ◽  
Electron Paramagnetic

AbstractAggregation of the microtubule-associated protein Tau is a hallmark of Alzheimer’s disease with Tau oligomers suspected as the most toxic agent. Tau is a client of Hsp90, though it is unclear whether and how the chaperone massages the structure of intrinsically disordered Tau. Using electron paramagnetic resonance, we extract structural information from the very broad conformational ensemble of Tau: Tau in solution is highly dynamic and polymorphic, though ‘paper-clip’-shaped by long-range contacts. Interaction with Hsp90 promotes an open Tau conformation, which we identify as the molecular basis for the formation of small Tau oligomers by exposure of the aggregation-prone repeat domain to other Tau molecules. At the same time, formation of Tau fibrils is inhibited. We therefore provide the nanometer-scale zoom into chaperoning an amyloid client, highlighting formation of oligomers as the consequence of this biologically relevant interaction.

scholarly journals Unexpected magnetic attraction: Evidence for an organized energy field in the human body

2021 ◽  
Vol 2 (4) ◽  
pp. 1-15
Author(s):  
James A. Thorp ◽  
◽  
K. E. Thorp ◽  
Emily K. Lile ◽  
John Viglione ◽  
...  
Keyword(s):  
Observational Study ◽  
Human Body ◽  
Prospective Observational Study ◽  
Deltoid Muscle ◽  
Maximum Score ◽  
Energy Field ◽  
Magnetic Attraction ◽  
Paper Clip ◽  
Neodymium Magnets

Introduction & Background: In recent months unexpected reports have surfaced claiming the presence of magnetic attraction in the shoulder regions of subjects who had recently received the COVID-19 vaccination. Purpose: To determine if such claims are legitimate or spurious. Methods: A prospective observational study was performed utilizing standard neodymium magnets and non-magnetized paper clips in a rigorously standardized application protocol. Magnets and paper clips were applied over various regions of both deltoid muscles. The attraction score was calculated by adding one point for each pole of the magnet that attached to each arm over the deltoid muscle for a maximum score of 4. Likewise, three sizes of paper clips were tested with a maximum score of 6. The field score was calculated by adding the magnet score to the paper clip score for a maximum score of 10 points

A Calibrated Paper Clip Is a Reliable Measure of Two-point Discrimination

2004 ◽  
Vol 11 (5) ◽  
pp. 710-714 ◽  
Author(s):  
John T. Finnell ◽  
Robert Knopp ◽  
Phelps Johnson ◽  
Patrick C. Holland ◽  
Warren Schubert
Keyword(s):  
Reliable Measure ◽  
Paper Clip

On alcohol burners and paper clips

PEDIATRICS ◽  
1974 ◽  
Vol 53 (5) ◽  
pp. 648-649
Author(s):  
Nicholas M. Nelson
Keyword(s):  
Good Deal ◽  
Simple Method ◽  
Paper Clip

Those readers who tend to be titillated into reading articles whose titles include such eye-catching phrases as "a simple method" may well, at first, be disappointed in the contribution of Lister et al. elsewhere in this issue of Pediatrics. Surely, one feels appendices which assault our senses with such polysymbolic multiple equations as these must relate to a method more accurately described as formidable and, at best, academic-certainly not practical! Now, a paper clip is, indeed, simple in concept and design-its functional application is self-evident. Yet, the engineer's calculations and mechanical drawings of the machinery which enabled production of such a basic instrument of civilized living are, no doubt, a good deal more complicated than Listers' illustrations and appendices.

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