IMPARTER, Phase 1 of an intervention to improve patients’ understanding of gene expression profiling tests in breast cancer

Purpose To compare participants’ knowledge about gene expression profiling (GEP) tests and recurrence risks after reading an information leaflet with that following viewing of an information film. Methods Using a randomised cross-over design, at time-point one (T1), women aged 45–75 years without breast cancer either read leaflets or watched information films about Oncotype DX or Prosigna tests. Participants answered nine questions assessing knowledge (maximum score 18). Next-day information in the opposite modality was provided and knowledge re-assessed. Additional questions probed which format was easiest to understand, participants’ preferences for film or leaflet and their reasons for these. Results 120 women participated (60 received OncotypeDX films and leaflets; 60 received the Prosigna versions). T1 mean knowledge scores were higher following film viewing (13.37) compared with that after reading leaflets (9.25) (mean difference 4.1; p < 0.0001; 95% CI 3.2, 5.0). When participants read leaflets first and subsequently viewed films, all increased their scores (mean + 6.08, from T1 of 9.25, p < 0.0001; 95% CI 5.44, 6.72). When films were viewed first, followed by leaflets, (36/60, 60%), participants’ scores declined (mean-1.55 from T1 of 13.37, p < 0.001; 95% CI -2.32, -0.78). A majority of participants expressed preferences for the films (88/120, 73.3%) irrespective as to whether they described OncotypeDX or Prosigna. Reasons included the clarity, ease of understanding, visual material and reassuring voice-over. Conclusion Discussions between oncologists and patients about recurrence risk results can be challenging. Information leaflets may aid understanding but often employ complex language. Information films significantly improved knowledge and were preferred by participants.

Osong, Value Transformation of Oral Tradition in Regional Language Learning of SMPN 1 Bulupoddo, Sinjai Regency

This study is a quantitative descriptive study that describes the ability to read blanks of eighth-grade students of SMPN 1 Bulupoddo, Sinjai Regency. Based on the presentation of the results of the data analysis above, it can be described in detail about the osong reading ability of the eighth-grade students of SMPN 1 Bulupoddo, Sinjai Regency. Students' test results in reading blanks are then analyzed based on predetermined criteria or assessment indicators, namely the pronunciation aspect with a score of 1 to 1, intonation aspect with a score of 1 to 3, gesture aspect with a score of 1 to 3, expression aspect with a score of 1 up to 3, the aspect of appreciation with a score of 1 to 3, the aspect of appearance with a score of 1 to 3. Of the six aspects of the assessment of reading blanks, the maximum score is 18. In the contents of elong osong itself, the theme contained in it is the figure of a Bugis human who is brave and does not stand still and becomes a coward towards the nation and homeland. The tones used are generally satirical and patronizing. The atmosphere or state of the reader's soul after reading or listening to the osong can be a booster or an incendiary. While the results of the current study emphasize the ability of students to read blanks. This is what distinguishes previous research from the results of the present study. Keywords: Osong, Value Transformation, Learning, Regional Language, Sinjai

Development of an Enrichment Book of Colloid Industry Products as a Source of Literacy for Senior High School Students

The aim of this research was to develop an enrichment book of colloid industry products as a source of literacy and to determine the quality of this book. The approach used in this study was Design-Based Research, which included four phases of development: 1) a questionnaire about needs was filled in by 5 teachers and 83 students; 2) the book was developed using CorelDraw X8 software and a literature search was conducted of online articles, journals and other supporting books; 3) cycles of testing were conducted, in which three experts and three peer reviewers assessed the book, and several revisions were produced; and 4) reflection and final evaluation were conducted, in which 5 teachers and 20 students from SMA N 2 Sleman, SMA N 2 Yogyakarta, SMA 1 Tempel, and MAN 3 Sleman assessed the substance, presentation, language and graphics of the book. Through this process, an enrichment book of colloidal industry products titled “Proses Pembuatan Koloid di Industri untuk SMA/MA Kelas XI” was produced. The book received a score 62.8 out of a maximum score of 70, which corresponded to a rating of ‘very good quality’. Keywords: colloid, literacy, enrichment book

Overview of Nurses Perception about Caring Based on Technology in the ICU and ER of Jember Region Hospital

Caring in acute and critical care rooms has a more complex and dynamic nature due to unstable patient conditions and requires more attention from nurses. Nurses' technological competence represents their caring based on nursing science practice. This study aimed to find out how nurses’perception of caring based on technology in the Intensive Care Unit and Emergency Room in Jember Region. This study used a quantitative method based on a descriptive survey. This study used a total sampling, with a total of 47 nurses as respondents. The researcher used a demographic questionnaire and modification of caring attribute, professional self-concept, and technological influence scale to collect data. In this study, univariate analysis was applied to analyze the data. The median score was 68, as the scores approach the maximum score of 76. This study demonstrates that nurses have a good perception toward caring based on technology. The conclusion on this study is nurses perception of caring based on technology are generally positive. To further improve nurses' perceptions of caring expressed through technological competence, the researcher advises the managerial department to facilitate education and training on technological competence in order to provide better care and caring to patients. Keywords: Caring Based on Technology; Nurses; Perception

Application of Visagism Concept to Assess the Co-Relation between the Temperament and Smile Esthetics: A Clinical Study

Background: Ability of a person to express a wide range of emotions with the movement of teeth and lips is called as a smile. Dentogenic concept considers gender, personality, age in harmonizing shapes of teeth with the face. Personality is unique for an individual. Unveiling personality traits, desires of the individual, translating them into natural tooth shapes to maintain the psychodentofacial harmony poses a major challenge to the clinician in designing a smile. Visagism is a novel concept that helps the dentists in providing restorations that involve esthetics psychological and social features of the created image, which influences the individual’s emotions. It involves the customization of an image. Aim and Objectives: To assess the co-relation between the smile esthetics and mental temperaments or personalities through the application of the concept of visagism. Methodology: A Digital camera (DSLR) for capturing the photographs and smile designing software will be used. Each subject will be instructed to occlude the teeth while capturing photographs. A validated questionnaire study will be conducted that will help to discover temperament of the subject. The answers will be evaluated and maximum score of the responses out of the list will be dominant temperament in that individual. Expected Outcome: Co-relation between this study might help clinicians to accurately assess the correlation between the temperament and the smile esthetics and eventually develop proper customisation of a smile with respect to the personality of the patient. Conclusion: If computer-assisted smile design and application of visagism concept would be accurate and reproducible, this might help and improve the planning of smile designing, the oral rehabilitations.

Myths and Misconceptions about Novel COVID-19 Outbreaks among Wardha City General Population

Background: COVID-19 is a unique pulmonary ailment due to coronavirus, producing extremely severe pulmonary illness. On March 11, 2020, WHO declared the SARS-CoV-2 incident a pandemic because of its deadly global spread. Objectives: To assess the myths and misconceptions about Novel COVID-19 outbreaks among the general population and associate the findings of the Novel COVID-19 outbreak with the selected demographic variable. Materials and Methods: This descriptive research paper was undertaken to assess the perceived myths and misconceptions about novel COVID-19 outbreaks among the general population at Paloti, district Wardha. The sampling technique was used Non – Probability Convenient. A total of 150 members of the general population who met the inclusion criteria were chosen for this study. To assess their perceived myths and misconceptions, a Likert Scale was constructed. Results: Findings of the study, 1.33% of general populations have disagreed, 10% were undecided, 50.67% of them were agreed, and 38% of them were strongly agreed about myths related to Novel COIVD-19. The Minimum perceived myths score was 19, and the maximum score was 48. The mean perceived myths score was 37.83±6.07, and the mean percentage of myths score was 75.66±12.14.0.67% of general populations were disagreed, 2% were undecided, 29.33% of them were agreed, and 68% of them were strongly agreed about misconceptions related to Novel COIVD-19. The minimum and highest misunderstanding scores were 18 and 49, respectively. The mean misunderstanding score was 83.179.09, while the mean misconception score was 41.584.54. There is no correlation between demographic factors and myths and misconceptions. Conclusion: According to this study, myths and misconceptions related to the novel COVID-19 are surprisingly low among the general population.

PuraStat RADA16 Self-Assembling Peptide Reduces Postoperative Abdominal Adhesion Formation in a Rabbit Cecal Sidewall Injury Model

Objective: To evaluate the effect of PuraStat (2.5% RADA16) administration on postoperative abdominal adhesion formation in an in vivo model.Methods: Anesthetized New Zealand white rabbits underwent cecal sidewall abrasion surgery in which the cecal serosa and juxtaposed parietal peritoneum were abraded after access through an abdominal midline incision. Eight animals were randomized to receive PuraStat administration at the interface of the injured tissues before incision closure, and five animals served as untreated controls. Treated animals received 3–12 ml PuraStat solution per lesion. Animals were sacrificed 14 days after surgery and examined for adhesion formation at the wound site.Results: At study terminus, adhesions were identified in 90% (9/10) of abraded cecum/peritoneal wound sites in untreated controls versus 25% (4/16) of PuraStat-treated sites (p = 0.004). Mean ± SD Total Adhesion Score (average of the values for extent + strength of the adhesion in both defects per animal; maximum score = 14 points) was significantly 76% lower in PuraStat-treated animals (2.0 ± 3.0 points) compared to untreated controls (8.2 ± 1.9 points) (p = 0.029). Mean adhesion coverage area of wound sites was 79% lower in PuraStat-treated animals than controls (p &lt; 0.001), and mean adhesion durability was 72% lower in PuraStat-treated animals versus controls (p = 0.005). Remnant hydrogel was observed at the wound sites of 75% of treated animals at postoperative Day 14.Conclusion: PuraStat treatment has a positive protective effect in the cecal sidewall injury model, and significantly reduces abdominal adhesion formation at the interface of the injured cecum and overlying peritoneal sidewall defect.

FAT score: an Indian insight to a novel diagnostic score to differentiate non-alcoholic steatohepatitis (NASH) from simple steatosis

Background The aim of this study was to propose a simple predictive score to differentiate NASH from simple steatosis. Results This study included 64 patients who had biopsy-proven NAFLD, of which 34 patients had steatohepatitis and 30 had simple steatosis. Clinical, anthropometric, and biochemical variables of the study population were analyzed. Univariate analysis showed platelet count, ferritin, and transaminases (ALT&AST) were predictors of NASH. This led to the proposal of a new diagnostic tool, FAT score (F signifies Ferritin, A indicates AST&ALT, T denotes t in Platelet) with AUROC of 0.95. The ROC curves for the significant variables were plotted and cutoff values were identified. Each component is awarded a score of 0 or 1, based on this cutoff value. The component is awarded a score of 1 if the component score is above the cutoff value and 0, if the score is below cutoff. The maximum score which can be obtained is 4. A score of ≥ 3 was able to predict NASH from simple steatosis with a sensitivity of 76.5% and a specificity of 100%. The score was validated with a cohort of 84 liver biopsy patients wherein a cutoff ≥ 3 was found to give a specificity of 100% in the validation cohort. Conclusions FAT score is a simple predictive model to differentiate NASH from simple steatosis (cutoff of more than or equal to 3) without performing a liver biopsy. A FAT score less than 3 rules out the need for biopsy.

Readiness of Medical Teams Caring for COVID-19 in the Intensive Care Units: A National Web-Based Survey in Indonesia

BACKGROUND: The coronavirus disease 2019 (COVID)-19 pandemic is a challenge for the intensive care unit (ICU) medical team. It requires management of space, stuff (medical equipment including drugs), staff, and system readiness (4S) to deal with the surge in the number of patients. AIM: This survey aims to describe the current readiness efforts among ICU medical team at the COVID-19 referral hospitals in Indonesia; space, stuff readiness, staff, and systems readiness. METHODS: We conducted a cross-sectional national web-based survey of ICUs across referral hospitals during pandemic COVID-19 in Indonesia from June to October 2020. The medical teams survey included 53 questions in multiple parts addressing five dimensions. A linear regression model was applied to determine the factors related with readiness. RESULTS: A total of 459 participants (83.6%) agreed to join in this study. The participants’ average age was 40.43 years (SD = 5.78). About 62.53% were male, 51.20% had bachelor degree, and 55.77% lived outside of Java Island. The mean of total score of medical team readiness was 2.76 (SD = 0.320) and the highest (maximum score) mean score of medical team readiness domain was stuff (2.81, SD = 7.72). Education, working experience, training, perception of risk of contracting COVID-19, and residence had a substantial effect on the readiness, with R2 values of 0.378, p < 0.05. CONCLUSIONS: This study provides an initial view of current preparedness efforts among a group of ICUs in Indonesia’s leading hospital during the first wave of pandemic. Interventions must be developed and implemented quickly to increase the medical team’s readiness to care for a future pandemic.

Is There a Distinction in Socialization Ability Between Children Who Are addicted to Gadgets and Those Who Are Not? A Comparison Study

The social skills of kindergarten children in the Tampan district are remain low, this can be seen from the children who do not want to be left by their parents when they enter class to study, even though teachers and other friends have persuaded them to study together and those children prefer to be alone. For this reason, researchers conducted a comparative study to examine the differences in social skills between the children who are addicted and not addicted to gadgets. This research method uses a comparative descriptive quantitative approach. The population in this study are all children aged 5-6 years in kindergarten throughout the Tampan District, amounted to 194 children. The sampling technique used was the purposive technique so that the samples of this study were 30 children addicted to gadgets and 30 children who were not addicted to gadgets. Data collection techniques using observation guidelines and documentation. Based on the results of data analysis and discussion, it can be concluded that a) The social skills of children who are not addicted to gadgets with a minimum score of 59, a maximum score of 99 and an average score of 55.10, while the social skills of children who are addicted to gadgets in kindergartens throughout the Tampan district with a minimum score of 41, while a maximum score of 57 with an average of 48.27, b) Differences in the social skills of children aged 5-6 years who are addicted to gadgets in kindergartens throughout the Tampan district are shown from the test results t shows tcount (7.416) > ttable (2.00) and the significance score (0.000) < (0.05) it means Ha is accepted, while Ho is rejected. The magnitude of the difference between children who are addicted and those who are not addicted on gadgets is 6.83%.