The JenaValve pericardial transcatheter aortic valve replacement system to treat aortic valve disease

Transcatheter aortic valve replacement is a valuable alternative technique to surgery and the spectrum of therapy continues to evolve. The JenaValve Pericaridal transcatheter aortic valve replacement System allows prosthesis fixation in a native, noncalcified aortic annulus with a unique paper clip-like anchorage mechanism. The low rate of paravalvular leakage and permanent pacemaker implantation emphasizes the further widespread use of the JenaValve – despite the limited data available. In May 2021, a CE mark for the transfemoral implantation in both aortic regurgitation and aortic stenosis was granted. However, no data have been published so far. The ongoing ALIGN trials are expected to provide the pending long-term data.

Unexpected magnetic attraction: Evidence for an organized energy field in the human body

Introduction & Background: In recent months unexpected reports have surfaced claiming the presence of magnetic attraction in the shoulder regions of subjects who had recently received the COVID-19 vaccination. Purpose: To determine if such claims are legitimate or spurious. Methods: A prospective observational study was performed utilizing standard neodymium magnets and non-magnetized paper clips in a rigorously standardized application protocol. Magnets and paper clips were applied over various regions of both deltoid muscles. The attraction score was calculated by adding one point for each pole of the magnet that attached to each arm over the deltoid muscle for a maximum score of 4. Likewise, three sizes of paper clips were tested with a maximum score of 6. The field score was calculated by adding the magnet score to the paper clip score for a maximum score of 10 points

Analisis Perubahan Besaran Listrik Pada Pemanas Induksi Menggunakan Inverter Setengah Jembatan

AbstrakNowadays induction heating has become one of the people's choices in the heating process both in industry and households. Induction heating technology is also growing. But the electrical quantities that change with the temperature changes in the induction heating process must also be analyzed. To make induction heating, we need a device that is capable of producing large electrical energy. This tool uses a 12 Volt DC voltage, strong current 10 ampere and with a 120 watt input power. This induction heater is made using a half bridge inverter which generates heat through waves at high frequencies. The resonant frequency used is 25kHz. From the test obtained an average temperature increase of 134.5 ° C at the 600th second with a paper clip load and with a voltage of 3.33 Volts, a current of 0.15 A, a power of 0.56 watts, and a heat of 19.5J, and a test with a load nails obtained an average temperature of 136 ° C at 360 seconds with a voltage of 4.54 V, a current of 0.27 A, power of 1.12 watts, and a heat of 33.6JKata kunci : Pemanas Induksi, frekuensi, suhu, Solenoide.

The mechanism of Hsp90-induced oligomerizaton of Tau

Aggregation of the microtubule-associated protein Tau is a hallmark of Alzheimer’s disease with Tau oligomers suspected as the most toxic agent. Tau is a client of the molecular chaperone Hsp90, although it is unclear whether and how the chaperone massages the structure of intrinsically disordered Tau. Using electron paramagnetic resonance, we extract structural information from the very broad conformational ensemble of Tau: Tau in solution is highly dynamic and polymorphic, although “paper clip”–shaped by long-range contacts. Interaction with Hsp90 promotes an open Tau conformation, which we identify as the molecular basis for the formation of small Tau oligomers by exposure of the aggregation-prone repeat domain to other Tau molecules. At the same time, formation of Tau fibrils is inhibited. We therefore provide the nanometer-scale zoom into chaperoning an amyloid client, highlighting formation of oligomers as the consequence of this biologically relevant interaction.

The molecular mechanism of Hsp90-induced oligomerization of Tau

Aggregation of the microtubule-associated protein Tau is a hallmark of Alzheimer’s disease with Tau oligomers suspected as the most toxic agent. Tau is a client of Hsp90, though it is unclear whether and how the chaperone massages the structure of intrinsically disordered Tau. Using electron paramagnetic resonance, we extract structural information from the very broad conformational ensemble of Tau: Tau in solution is highly dynamic and polymorphic, though ‘paper-clip’-shaped by long-range contacts. Interaction with Hsp90 promotes an open Tau conformation, which we identify as the molecular basis for the formation of small Tau oligomers by exposure of the aggregation-prone repeat domain to other Tau molecules. At the same time, formation of Tau fibrils is inhibited. We therefore provide the nanometer-scale zoom into chaperoning an amyloid client, highlighting formation of oligomers as the consequence of this biologically relevant interaction.