Obesity Appears to Be a Stronger Asthma Risk Factor in Women

2006 ◽  
Vol 34 (7) ◽  
pp. 70
Author(s):  
BRUCE JANCIN
Keyword(s):  
Risk Factor ◽  
Asthma Risk

scholarly journals Interleukin-13 +1923C/T Polymorphism Is Associated with Asthma Risk: A Meta-Analysis

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Yongan Liu ◽  
Tao Liu ◽  
Wei Nie ◽  
Guoxiang Lai ◽  
Qingyu Xiu
Keyword(s):  
Sensitivity Analysis ◽  
Risk Factor ◽  
Meta Analysis ◽  
Study Quality ◽  
China National Knowledge Infrastructure ◽  
High Quality ◽  
Interleukin 13 ◽  
Knowledge Infrastructure ◽  
Asthma Risk ◽  
Codominant Model

There are controversies on the association betweeninterleukin-13(IL-13) +1923C/T polymorphism (rs1295686) and the risk of asthma. We performed this study to assess the association by the method of meta-analysis. A systematic search current to October 16, 2012, was conducted using PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) and identified ten studies comprising 13698 cases and 38209 controls. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. There was a significant association betweenIL-13+1923C/T polymorphism and asthma risk in codominant model. When stratified by ethnicity,IL-13+1923C/T polymorphism remained significantly associated with higher asthma risk in Asians and Caucasians. In the subgroup analysis by study quality, a significantly increased asthma risk was observed in high quality studies. Sensitivity analysis and cumulative analysis further strengthened the validity of the results. No publication bias was found in this meta-analysis. In conclusion, results from this meta-analysis suggested thatIL-13+1923C/T polymorphism was a risk factor of asthma.

scholarly journals Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: a meta-analysis based on 24 publications

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Danyal Imani ◽  
Mohammad Masoud Eslami ◽  
Gholamreza Anani-Sarab ◽  
Mansur Aliyu ◽  
Bahman Razi ◽  
...  
Keyword(s):  
Risk Factor ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Age Groups ◽  
Positive Association ◽  
Interleukin 4 ◽  
Reliable Estimate ◽  
Significant Positive Association ◽  
Asthma Risk ◽  
Allelic Model

Abstract Background Previous studies evaluated the association of IL-4 C33T polymorphism and risk of bronchial asthma but failed to establish a consistent conclusive association. In the present meta-analysis, we intend to define a more reliable estimate of the association in the presence of filling published literature. Methods An exhaustive search in Web of Science, Scopus, and PubMed databases was performed to identify all relevant publications before September 2020, and 24 publications (28 studies) with 6587 cases and 8408 controls were included in final analysis. The association between polymorphism and risk of asthma were measured by Odd ratios (ORs) and 95% confidence intervals (CIs). Moreover, Cochran’s Q and the I2 statistics were used to evaluate the degree of heterogeneity between studies. Results In the overall study populations, a significant positive association was detected under all genotype models and announced the IL-4 C33T polymorphism as a potential risk factor in the pathogenesis of asthma. In the subgroup analysis by age, a significant association between IL-4 C33T polymorphism and risk of asthma in different age groups was identified in allelic model, which highlighted the predisposing role of the T allele for the asthma risk in all three age groups. Furthermore, the results of subgroup analysis by continent were heterogenous. Accordingly, IL-4 C33T polymorphism was a risk factor in Europeans (all models except heterozygote comparison), Americans (all models except recessive and homozygote comparison) and Asians (just recessive and allelic model). Finally, the ethnicity-specific analysis disclosed a significant association between IL-4 C33T polymorphism and asthma risk in Caucasians (all genotype models except heterozygote comparison), while this association was not significant in African-Americans. Conclusions This study suggests that IL-4 C33T polymorphism potentially acts as a risk factor for asthma in different ethnicities and age groups.

scholarly journals Prevalence of asthma, its correlates, and validation of the Pre-School Asthma Risk Factors Scale (PS-ARFS) among preschool children in Lebanon

2021 ◽  
Vol 49 (1) ◽  
pp. 40-49
Author(s):  
Souheil Hallit ◽  
Hala Sacre ◽  
Nelly Kheir ◽  
Rabih Hallit ◽  
Mirna Waked ◽  
...  
Keyword(s):  
Risk Factor ◽  
Preschool Children ◽  
Area Under The Curve ◽  
Heating System ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Parental History ◽  
Study Objective ◽  
Asthma Risk ◽  
History Of

Objectives: The Asthma Risk Factor Scale (ARFS) is used to screen for asthma in Lebanese pre-school children (aged 3–16 years). The study objective was to describe factors associated with asthma, confirm ARFS score validity among Lebanese preschool children, and develop a risk score for asthma diagnosis in this age group (Pre-School Asthma Risk Factor Scale [PS-ARFS]). Methods: A cross-sectional study enrolled 515 preschool children (November 2018 and March 2019). The ARFS is a 15-item tool that assesses children’s environmental exposure, parental history of asthma, and dietary habits.Results: The percentage of asthmatic children was 8.2%. Higher odds of asthma in children were associated with living near a prairie sprayed with pesticides (odds ratio [OR] = 2.33), playing out-doors (OR = 2.89), having a heater in the bedroom (OR = 10.73), attending a nursery (OR = 2.91), having a mother who smokes cigarettes (OR = 3.35) or water pipe (OR = 2.46), a sister with a history of seasonal allergy (OR = 6.81), and a parental history (mother and father) of asthma (OR = 6.15 and OR = 9.83, respectively). Higher ARFS scores (OR = 1.144) were associated with higher odds of asthma. Accordingly, the PS-ARFS was created according to the following formula: ARFS score + (playing out-door × 2.4) + (heating system in the bedroom × 12.9) + (having attended a nursery × 2.5) (area under the curve = 0.908 [0.860–0.957]; P < 0.001); at value: 14.20, Se = 84.3% and Sp = 90.9%.Conclusion: PS-ARFS is suggested for screening of asthma in preschool children in an epidemiological setting and in the absence of spirometry.

Asthma risk factor assessment: what are the needs of inner-city families?

2006 ◽  
Vol 97 (1) ◽  
pp. S11-S15 ◽  
Author(s):  
Karen Warman ◽  
Ellen J. Silver ◽  
Pamela R. Wood
Keyword(s):  
Risk Factor ◽  
Inner City ◽  
Risk Factor Assessment ◽  
Asthma Risk

scholarly journals Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: A meta-analysis based on 24 studies

2020 ◽  
Author(s):  
Danyal Imani ◽  
Mohammad Masoud Eslami ◽  
Gholamreza Anani Sarab ◽  
Mansur Aliyu ◽  
Bahman Razi ◽  
...  
Keyword(s):  
Risk Factor ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Age Groups ◽  
Positive Association ◽  
Interleukin 4 ◽  
Reliable Estimate ◽  
Significant Positive Association ◽  
Asthma Risk ◽  
Allelic Model

Abstract Background: Previous studies evaluated the association of IL-4 C33T polymorphism and risk of bronchial asthma but failed to establish a consistent conclusive association. In the present meta-analysis, we intend to define a more reliable estimate of the association in the presence of filling published literature.Methods: An exhaustive search in Web of Science, Scopus, and PubMed databases was performed to identify all relevant publications before September 2020, and 24 publications (28 studies) with 6587 cases and 8408 controls were included in final analysis. The association between polymorphism and risk of asthma were measured by Odd ratios (ORs) and 95% confidence intervals (CIs). Moreover, Cochran's Q and the I2 statistics were used to evaluate the degree of heterogeneity between studiesResults: In the overall study populations, a significant positive association was detected under all genotype models and announced the IL-4 C33T polymorphism as a potential risk factor in the pathogenesis of asthma. In the subgroup analysis by age, a significant association between IL-4 C33T polymorphism and risk of asthma in different age groups was identified in allelic model, which highlighted the predisposing role of the T allele for the asthma risk in all three age groups. Furthermore, the results of subgroup analysis by continent were heterogenous. Accordingly, IL-4 C33T polymorphism was a risk factor in Europeans (all models except heterozygote comparison), Americans (all models except recessive and homozygote comparison) and Asians (just recessive and allelic model). Finally, the ethnicity-specific analysis disclosed a significant association between IL-4 C33T polymorphism and asthma risk in Caucasians (all genotype models except heterozygote comparison), while this association was not significant in African-Americans.Conclusions: This study suggests that IL-4 C33T polymorphism potentially acts as a risk factor for asthma in different ethnicities and age groups.

scholarly journals Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: A meta-analysis based on 24 studies

2020 ◽  
Author(s):  
Danyal Imani ◽  
Mohammad Masoud Eslami ◽  
Gholamreza Anani Sarab ◽  
Mansur Aliyu ◽  
Bahman Razi ◽  
...  
Keyword(s):  
Risk Factor ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Age Groups ◽  
Positive Association ◽  
Interleukin 4 ◽  
Reliable Estimate ◽  
Significant Positive Association ◽  
Asthma Risk ◽  
Allelic Model

Abstract Background: Previous studies evaluated the association of IL-4 C33T polymorphism and risk of bronchial asthma but failed to establish a consistent conclusive association. In the present meta-analysis, we intend to define a more reliable estimate of the association in the presence of filling published literature.Methods: An exhaustive search in web of science, Scopus, and PubMed databases was performed to identify all relevant publications before September 2020, and 24 publications (28 studies) with 6587 cases and 8408 controls were included in final analysis. The association between polymorphism and risk of asthma were measured by Odd ratios (ORs) and 95% confidence intervals (CIs). Moreover, Cochran Q and the I2 statistics were used to evaluate the degree of heterogeneity between studiesResults: In the overall study populations, a significant positive association was detected under all genotype models and announced the IL-4 C33T polymorphism as a potential risk factor in the pathogenesis of asthma. In the subgroup analysis by age, a significant association between IL-4 C33T polymorphism and risk of asthma in different age groups was identified in allelic model, which highlighted the predisposing role of the T allele for the asthma risk in all three age groups. Furthermore, the results of subgroup analysis by continent were heterogenous. Accordingly, IL-4 C33T polymorphism was a risk factor in Europeans (all models except heterozygote compression), Americans (all models except recessive and homozygote compression) and Asians (just recessive and allelic model). Finally, the ethnicity-specific analysis disclosed a significant association between IL-4 C33T polymorphism and asthma risk in Caucasians (all genotype models except heterozygote comparison), while this association was not significant in American-Africans.Conclusions: This study suggests that IL-4 C33T polymorphism potentially acts as a risk factor for asthma in different ethnicities and age groups.

scholarly journals Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: A meta-analysis based on 24 studies

2020 ◽  
Author(s):  
Danyal Imani ◽  
Mohammad Masoud Eslami ◽  
Gholamreza Anani Sarab ◽  
Mansur Aliyu ◽  
Bahman Razi ◽  
...  
Keyword(s):  
Risk Factor ◽  
Meta Analysis ◽  
Age Groups ◽  
Asian Population ◽  
Final Analysis ◽  
Recessive Model ◽  
Interleukin 4 ◽  
Reliable Estimate ◽  
Asthma Risk

Abstract Background Previous studies evaluate an association of IL-4 C33T polymorphism and risk of bronchial asthma but failed to establish a consistent conclusive association between the two. In the present meta-analysis, we intend to define a more reliable estimate of the association in the presence of filling published literature.Methods An exhaustive search in web of science, Scopus, and PubMed databases was performed to identify all relevant publications before November 2019, and 24 studies with 6587 cases and 8408 controls were included in final analysis. The association between polymorphism and risk of asthma were measured by Odd ratios (ORs) and 95% confidence intervals (CIs). Moreover, Cochran Q and the I2 statistics were used to evaluated the degree of heterogeneity between studiesResults In the overall study populations, the result illustrated that IL-4 C33T polymorphism was a risk factor in the pathogenesis of asthma. In the subgroup analysis by age, a significant association between IL-4 SNP (C33T) and risk of asthma in different age groups was identified in allelic model, which highlighted the predisposing role of the T allele for the asthma risk in all three age groups. In the Asian population, there was a significant association between IL-4 SNP (C33T) and risk of asthma under recessive and allelic models. Finally, there was a significant association between IL-4 SNP (C33T) and asthma risk in Caucasian under recessive model and allelic model.Conclusions This study suggests that IL-4 C33T single nucleotide polymorphism potentially acts as a risk factor for asthma in different ethnicities and age groups.

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