Closed-Loop System Improves Glucose Control

2010 ◽  
Vol 40 (4) ◽  
pp. 42-43
Author(s):  
MIRIAM E. TUCKER
Keyword(s):  
Glucose Control ◽  
Closed Loop ◽  
Loop System ◽  
Closed Loop System

scholarly journals Day and night glucose control using a hybrid closed loop system for the management of type 1 diabetes

2015 ◽  
Vol 2015 (S1) ◽  
Author(s):  
Martin de Bock ◽  
Anirban Roy ◽  
Julie Dart ◽  
Barry Keenan ◽  
Elizabeth Davis ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glucose Control ◽  
Closed Loop ◽  
Loop System ◽  
Closed Loop System

scholarly journals Survey about do-it-yourself closed loop systems in the treatment of diabetes in Germany

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243465
Author(s):  
Anna Laura Herzog ◽  
Jonas Busch ◽  
Christoph Wanner ◽  
Holger K. von Jouanne-Diedrich
Keyword(s):  
Blood Glucose ◽  
Glucose Control ◽  
Closed Loop ◽  
Artificial Pancreas ◽  
Direct Interaction ◽  
Loop System ◽  
Closed Loop System ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Do It Yourself

Continuous glucose monitoring (CGM) improves treatment with lower blood glucose levels and less patient effort. In combination with continuous insulin application, glycemic control improves and hypoglycemic episodes should decrease. Direct feedback of CGM to continuous subcutaneous insulin application, using an algorithm is called a closed-loop (CL) artificial pancreas system. Commercial devices stop insulin application by predicting hypoglycemic blood glucose levels through direct interaction between the sensor and pump. The prediction is usually made for about 30 minutes and insulin delivery is restarted at the previous level if a rise in blood glucose is predicted within the next 30 minutes (hybrid closed loop system, HCL this is known as a predictive low glucose suspend system (PLGS)). In a fully CL system, sensor and pump communicate permanently with each other. Hybrid closed-loop (HCL) systems, which require the user to estimate the meal size and provide a meal insulin basis, are commercially available in Germany at the moment. These systems result in fewer hyperglycemic and hypoglycemic episodes with improved glucose control. Open source initiatives have provided support by building do-it-yourself CL (DIYCL) devices for automated insulin application since 2014, and are used by a tech-savvy subgroup of patients. The first commercial hybrid CL system has been available in Germany since September 2019. We surveyed 1054 patients to determine which devices are currently used, which features would be in demand by potential users, and the benefits of DIYCL systems. 9.7% of these used a DIYCL system, while 50% would most likely trust these systems but more than 85% of the patients would use a commercial closed loop system, if available. The DIYCL users had a better glucose control regarding their time in range (TIR) and glycated hemoglobin (HbA1c).

Glucose Control in Adults with Type 1 Diabetes Using a Medtronic Prototype Enhanced-Hybrid Closed-Loop System: A Feasibility Study

2019 ◽  
Vol 21 (9) ◽  
pp. 499-506 ◽  
Author(s):  
Melissa H. Lee ◽  
Sara Vogrin ◽  
Barbora Paldus ◽  
Hannah M. Jones ◽  
Varuni Obeyesekere ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Feasibility Study ◽  
Glucose Control ◽  
Closed Loop ◽  
Loop System ◽  
Closed Loop System ◽  
System A

scholarly journals Glucose control during Ramadan fasting in a teenager with type 1 diabetes on MiniMed 670G hybrid closed-loop system

2019 ◽  
Vol 57 (1) ◽  
pp. 105-107 ◽  
Author(s):  
Goran Petrovski ◽  
Fawziya Al Khalaf ◽  
Judith Campbell ◽  
Khalid Hussain ◽  
Hannah Fisher ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glucose Control ◽  
Closed Loop ◽  
Loop System ◽  
Closed Loop System ◽  
Ramadan Fasting

Glucose Control Using a Standard Versus an Enhanced Hybrid Closed Loop System: A Randomized Crossover Study

2019 ◽  
Vol 21 (1) ◽  
pp. 56-58 ◽  
Author(s):  
Barbora Paldus ◽  
Melissa H. Lee ◽  
Hannah M. Jones ◽  
Sybil A. McAuley ◽  
Jodie C. Horsburgh ◽  
...  
Keyword(s):  
Crossover Study ◽  
Glucose Control ◽  
Closed Loop ◽  
Loop System ◽  
Closed Loop System ◽  
System A ◽  
Randomized Crossover Study

scholarly journals Realizing a Closed-Loop (Artificial Pancreas) System for the Treatment of Type 1 Diabetes

2019 ◽  
Vol 40 (6) ◽  
pp. 1521-1546 ◽  
Author(s):  
Rayhan A Lal ◽  
Laya Ekhlaspour ◽  
Korey Hood ◽  
Bruce Buckingham
Keyword(s):  
Type 1 Diabetes ◽  
Glucose Control ◽  
Closed Loop ◽  
Diabetes Management ◽  
Artificial Pancreas ◽  
Loop System ◽  
Closed Loop Control ◽  
Closed Loop System ◽  
Loop Control

Abstract Recent, rapid changes in the treatment of type 1 diabetes have allowed for commercialization of an “artificial pancreas” that is better described as a closed-loop controller of insulin delivery. This review presents the current state of closed-loop control systems and expected future developments with a discussion of the human factor issues in allowing automation of glucose control. The goal of these systems is to minimize or prevent both short-term and long-term complications from diabetes and to decrease the daily burden of managing diabetes. The closed-loop systems are generally very effective and safe at night, have allowed for improved sleep, and have decreased the burden of diabetes management overnight. However, there are still significant barriers to achieving excellent daytime glucose control while simultaneously decreasing the burden of daytime diabetes management. These systems use a subcutaneous continuous glucose sensor, an algorithm that accounts for the current glucose and rate of change of the glucose, and the amount of insulin that has already been delivered to safely deliver insulin to control hyperglycemia, while minimizing the risk of hypoglycemia. The future challenge will be to allow for full closed-loop control with minimal burden on the patient during the day, alleviating meal announcements, carbohydrate counting, alerts, and maintenance. The human factors involved with interfacing with a closed-loop system and allowing the system to take control of diabetes management are significant. It is important to find a balance between enthusiasm and realistic expectations and experiences with the closed-loop system.

234-OR: Postprandial Glucose Control Using the Medtronic Advanced Hybrid Closed-Loop System: Faster-Acting Insulin Aspart vs. Insulin Aspart

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 234-OR
Author(s):  
MELISSA H. LEE ◽  
SARA VOGRIN ◽  
BARBORA PALDUS ◽  
DALE MORRISON ◽  
DESSI ZAHARIEVA ◽  
...  
Keyword(s):  
Insulin Aspart ◽  
Glucose Control ◽  
Closed Loop ◽  
Postprandial Glucose ◽  
Loop System ◽  
Closed Loop System ◽  
Acting Insulin

scholarly journals Glucose Control Using a Standard vs. an Enhanced Hybrid Closed-Loop System—A Pilot Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 986-P
Author(s):  
BARBORA PALDUS ◽  
MELISSA H. LEE ◽  
HANNAH JONES ◽  
SYBIL A. MCAULEY ◽  
JODIE C. HORSBURGH ◽  
...  
Keyword(s):  
Pilot Study ◽  
Glucose Control ◽  
Closed Loop ◽  
Loop System ◽  
Closed Loop System ◽  
System A
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