Modulation of the neuronal circuitry subserving working memory in healthy human subjects by repetitive transcranial magnetic stimulation

2000 ◽  
Vol 280 (3) ◽  
pp. 167-170 ◽  
Author(s):  
Felix M. Mottaghy ◽  
Bernd J. Krause ◽  
Lars J. Kemna ◽  
Rudolf Töpper ◽  
Lutz Tellmann ◽  
...  
Keyword(s):  
Working Memory ◽  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Human Subjects ◽  
Healthy Human ◽  
Neuronal Circuitry ◽  
Healthy Human Subjects

The effects of repetitive transcranial magnetic stimulation on cortical inhibition in healthy human subjects

2006 ◽  
Vol 174 (3) ◽  
pp. 403-412 ◽  
Author(s):  
Zafiris J. Daskalakis ◽  
Bertram Möller ◽  
Bruce K. Christensen ◽  
Paul B. Fitzgerald ◽  
Carolyn Gunraj ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Human Subjects ◽  
Cortical Inhibition ◽  
Healthy Human ◽  
Healthy Human Subjects

Intracortical excitatory and inhibitory phenomena to paired transcranial magnetic stimulation in healthy human subjects: differences between the right and left hemisphere

2000 ◽  
Vol 288 (3) ◽  
pp. 171-174 ◽  
Author(s):  
Paola Cicinelli ◽  
Raimondo Traversa ◽  
Massimiliano Oliveri ◽  
Maria Giuseppina Palmieri ◽  
Maria Maddalena Filippi ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Left Hemisphere ◽  
Magnetic Stimulation ◽  
Human Subjects ◽  
Healthy Human ◽  
Healthy Human Subjects ◽  
The Right

scholarly journals Predictive Role of Executive Function in the Efficacy of Intermittent Theta Burst Transcranial Magnetic Stimulation Modalities for Treating Methamphetamine Use Disorder—A Randomized Clinical Trial

2021 ◽  
Vol 12 ◽  
Author(s):  
Li-Jin Wang ◽  
Lin-Lin Mu ◽  
Zi-Xuan Ren ◽  
Hua-Jun Tang ◽  
Ya-Dong Wei ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Working Memory ◽  
Executive Function ◽  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Therapeutic Effects ◽  
Sham Stimulation ◽  
Theta Burst ◽  
Stimulation Group

Background: Repetitive transcranial magnetic stimulation (rTMS) has therapeutic effects on craving in methamphetamine (METH) use disorder (MUD). The chronic abuse of METH causes impairments in executive function, and improving executive function reduces relapse and improves treatment outcomes for drug use disorder. The purpose of this study was to determine whether executive function helped predict patients' responses to rTMS treatment.Methods: This study employed intermittent theta burst stimulation (iTBS) rTMS modalities and observed their therapeutic effects on executive function and craving in MUD patients. MUD patients from an isolated Drug Rehabilitation Institute in China were chosen and randomly allocated to the iTBS group and sham-stimulation group. All participants underwent the Behavior Rating Inventory of Executive Function - Adult Version Scale (BRIEF-A) and Visual Analog Scales (VAS) measurements. Sixty-five healthy adults matched to the general condition of MUD patients were also recruited as healthy controls.Findings: Patients with MUD had significantly worse executive function. iTBS groups had better treatment effects on the MUD group than the sham-stimulation group. Further Spearman rank correlation and stepwise multivariate regression analysis revealed that reduction rates of the total score of the BRIEF-A and subscale scores of the inhibition factor and working memory factor in the iTBS group positively correlated with improvements in craving. ROC curve analysis showed that working memory (AUC = 87.4%; 95% CI = 0.220, 0.631) and GEC (AUC = 0.761%; 95% CI = 0.209, 0.659) had predictive power to iTBS therapeutic efficacy. The cutoff values are 13.393 and 59.804, respectively.Conclusions: The iTBS rTMS had a better therapeutic effect on the executive function of patients with MUD, and the improved executive function had the potential to become a predictor for the efficacy of iTBS modality for MUD treatment.Clinical Trial Registration:ClinicalTrials.gov, identifier: ChiCTR2100046954.

State-Dependent Effects of Prefrontal Repetitive Transcranial Magnetic Stimulation on Emotional Working Memory

2013 ◽  
Vol 6 (6) ◽  
pp. 905-912 ◽  
Author(s):  
Anne Weigand ◽  
Aline Richtermeier ◽  
Melanie Feeser ◽  
Jia Shen Guo ◽  
Benny B. Briesemeister ◽  
...  
Keyword(s):  
Working Memory ◽  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
State Dependent

scholarly journals Repetitive transcranial magnetic stimulation increases phase-amplitude coupling

2017 ◽  
Author(s):  
Chie Nakatani ◽  
Caitlin Mullin ◽  
Johan Wagemans ◽  
Cees van Leeuwen
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Neuronal Firing ◽  
Neural Mass Model ◽  
Mass Model ◽  
Healthy Human ◽  
Lateral Occipital Complex ◽  
Sham Condition ◽  
Phase Amplitude

AbstractA prominent feature of brain activity with relevance to cognitive processes is Phase-Amplitude Coupling (PAC) between slow and fast oscillatory signals. A newly developed neural mass model of cross-frequency coupling [1] predicts, counter-intuitively, that PAC shows sustained increases after repetitive Transcranial Magnetic Stimulation (rTMS). This is because rTMS leads to simultaneous neuronal firing in distinct regions, thereby enhancing the connectivity that, according to the model, is needed for PAC to be increased. We tested this prediction in healthy human volunteers. Two seconds of 10Hz rTMS were applied to the intraparietal sulcus, temporal-parietal junction, and lateral occipital complex. PAC in the subsequent electro-encephalogram was analyzed for two band pairs, theta-gamma and alpha-gamma, and compared to a sham condition. For all stimulation loci, PAC was higher in both band pairs after rTMS than in the sham condition. These results were found to be conform the model prediction. The perspective for using rTMS to modulate cross-band coupling is discussed.

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