Convulsive disorder and the genetics of signal transduction; a study of a low molecular weight protein tyrosine phosphatase in a pediatric sample

2002 ◽  
Vol 333 (3) ◽  
pp. 159-162 ◽  
Author(s):  
Nunzio Bottini ◽  
Patrizia Saccucci ◽  
Antonella Piciullo ◽  
Paola Iannetti ◽  
Nazareno Lucarini ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Molecular Weight ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Low Molecular Weight ◽  
Molecular Weight Protein ◽  
Convulsive Disorder ◽  
Protein Tyrosine ◽  
Weight Protein ◽  
Low Molecular Weight Protein

scholarly journals Inflammatory Bowel Disease: Are There Gender Differences in the Genetics of Signal Transduction? A Preliminary Study of Cytosolic Low Molecular Weight Protein Tyrosine Phosphatase

2000 ◽  
Vol 16 (3-4) ◽  
pp. 163-166 ◽  
Author(s):  
Nunzio Bottini ◽  
Fulvia Gloria-Bottini ◽  
Nazzareno Lucarini ◽  
Pier Giulio Ronchetti ◽  
Luigi Fontana
Keyword(s):  
Signal Transduction ◽  
Molecular Weight ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Low Molecular Weight ◽  
Molecular Weight Protein ◽  
High Concentration ◽  
Protein Tyrosine ◽  
Weight Protein ◽  
Low Molecular Weight Protein

The phenotype of cytosolic Low Molecular Weight Protein Tyrosine Phosphatase (cLMWPTP or ACP1), an enzyme involved in signal transduction of insulin, PDGF and T-cell receptors, has been determined in 71 patients with Crohn's Disease (CD: 37 males and 34 females), 49 patients with Ulcerative Colitis (UC: 27 males and 22 females) and 358 consecutive newborns (194 males and 164 females). cLMWPTP phenotypes showing a high concentration of F isoforms are associated with CD in females and with UC in males. Since PTPases counteract the effects of protein tyrosines kinases, a high concentration of F isoform of cLMWPTP may influence the mucosal response to pathogenic factors, increasing susceptibility to CD in females and to UC in males.

1742-P: Targeting the Low Molecular Weight Protein Tyrosine Phosphatase for Obesity-Associated Diabetes Therapy

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1742-P
Author(s):  
STEPHANIE M. STANFORD ◽  
MICHAEL A. DIAZ ◽  
JIWEN J. ZOU ◽  
ROBERT J. ARDECKY ◽  
ANTHONY PINKERTON ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Low Molecular Weight ◽  
Molecular Weight Protein ◽  
Diabetes Therapy ◽  
Protein Tyrosine ◽  
Weight Protein ◽  
Low Molecular Weight Protein

Kinetic Characterization of Bovine Lung Low-Molecular-Weight Protein Tyrosine Phosphatase

1998 ◽  
Vol 24 (3) ◽  
pp. 269-272 ◽  
Author(s):  
Marilia A. R. Buzalaf ◽  
E. M. Taga ◽  
JosÉ M. Granjeiro ◽  
Carmen V. Ferreira ◽  
ValÉRia A. Lourençā ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Low Molecular Weight ◽  
Kinetic Characterization ◽  
Molecular Weight Protein ◽  
Protein Tyrosine ◽  
Weight Protein ◽  
Low Molecular Weight Protein

scholarly journals Modulation of Src Activity by Low Molecular Weight Protein Tyrosine Phosphatase During Osteoblast Differentiation

2008 ◽  
Vol 22 (5-6) ◽  
pp. 497-506 ◽  
Author(s):  
Willian F. Zambuzzi ◽  
José M. Granjeiro ◽  
Kaushal Parikh ◽  
Saravanan Yuvaraj ◽  
Maikel P. Peppelenbosch ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Protein Tyrosine Phosphatase ◽  
Osteoblast Differentiation ◽  
Tyrosine Phosphatase ◽  
Low Molecular Weight ◽  
Molecular Weight Protein ◽  
Protein Tyrosine ◽  
Weight Protein ◽  
Low Molecular Weight Protein
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