Gemfibrozil reduces non-high-density lipoprotein cholesterol in exogenously hypercholesterolemic (ExHC) rats fed a high-cholesterol diet

Consumption of functional foods for lowering serum cholesterol has globally gained acceptance by the general public. Turtle jelly (TJ), also called gui-ling-gao, is a popular traditional functional food in southern China. The hypocholesterolemic effect of consuming TJ was investigated in rats fed with normal diet, high-cholesterol diet or high-cholesterol diet supplemented with simvastatin (3 mg/kg bw per day, p.o.) or TJ (3.3 or 10 mL/kg bw per day, p.o.) for 30 days. TJ markedly reversed the increased serum total cholesterol, increased high-density lipoprotein, and decreased high-density lipoprotein induced by hypercholesterolemic diet with a dose-dependent improvement on the atherogenic index. It also demonstrated good hepatoprotective function by reducing fat depositions and overall lipid contents in the liver and increasing the activities of hepatic antioxidative enzymes. The blunted nitric oxide/endothelium-mediated aortic relaxation in rats fed with hypercholesterolemic diet was partially restored after TJ consumption. It is postulated that the hypocholesterolemic effect is the primary beneficial effect given by TJ; it then leads to secondary beneficial effects such as vasoprotective and hepatoprotective functions. The results revealed that TJ could block the downregulation of LDLR and PEPCK and upregulation of PPARαmRNA and protein expressions in the livers of rats fed with hypercholesterolemic diet.

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Spirulina platensis effects on the levels of total cholesterol, HDL and triacylglycerols in rabbits fed with a hypercholesterolemic diet

Brazilian Archives of Biology and Technology ◽

10.1590/s1516-89132008000200022 ◽

2008 ◽

Vol 51 (2) ◽

pp. 405-411 ◽

Cited By ~ 40

Author(s):

Luciane Maria Colla ◽

Ana Luiza Muccillo-Baisch ◽

Jorge Alberto Vieira Costa

Keyword(s):

High Density Lipoprotein ◽

Total Cholesterol ◽

Spirulina Platensis ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

High Density ◽

High Cholesterol Diet ◽

Cholesterol Diet ◽

High Cholesterol ◽

Hypercholesterolemic Diet

In this work, hypercholesterolemia was induced in rabbits by feeding them a high cholesterol diet (CD, 350 mg/d) and the effects of supplementing this diet with 0.5 g/d Spirulina platensis was evaluated by measuring the levels of serum total-cholesterol (TC), triacylglycerols (TAG) and high-density lipoprotein (HDL-cholesterol) at the start of the experiment and after 30 d and 60 d. It was found that the levels of serum cholesterol decreased from 1,054±101 mg.dL-1 in the rabbits fed a CD without S. platensis to 516±163 mg.dL-1 to those fed with a high cholesterol diet supplemented with S. platensis (significant at p <0.0001). The addition of Spirulina to the cholesterolemic diet did not cause significative decrease on the levels of triacylglycerols in the animals. The levels of serum high-density lipoprotein (HDL-cholesterol) was 73±31 mg.dL-1 for rabbits fed a CD without S. platensis as compared to 91.0±15.7 mg.dL-1 in those fed a CD supplemented with S. platensis (significant at p=0.1533).

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High density lipoprotein-cholesterol changes in children with high cholesterol levels at birth

European Journal of Pediatrics ◽

10.1007/s00431-001-0863-y ◽

2001 ◽

Vol 161 (2) ◽

pp. 94-98 ◽

Cited By ~ 19

Author(s):

Sara Bastida ◽

Francisco J. Sánchez-Muniz ◽

Rafael Cuena ◽

Sagrario Perea ◽

Angel Aragonés

Keyword(s):

High Density Lipoprotein ◽

High Density Lipoprotein Cholesterol ◽

Density Lipoprotein ◽

High Density ◽

Lipoprotein Cholesterol ◽

High Cholesterol ◽

Cholesterol Levels

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Abstract: P1440 NANSHETENG, A TRADITIONAL CHINESE HERB INCREASES THE LEVEL AND ANTI-ATHEROSCLEROTIC FUNCTION OF HIGH DENSITY LIPOPROTEIN IN MICE FED WITH HIGH FAT HIGH CHOLESTEROL DIET

Atherosclerosis Supplements ◽

10.1016/s1567-5688(09)71448-5 ◽

2009 ◽

Vol 10 (2) ◽

pp. e1490

Author(s):

S Qin ◽

H Sang ◽

Y Zhang ◽

J Wang ◽

X Chen

Keyword(s):

High Density Lipoprotein ◽

Chinese Herb ◽

Density Lipoprotein ◽

High Density ◽

High Cholesterol Diet ◽

Cholesterol Diet ◽

High Cholesterol ◽

High Fat ◽

Traditional Chinese Herb

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The effect of a high cholesterol and saturated fat diet on serum high-density lipoprotein-cholesterol, apoprotein A-I, and apoprotein E levels in normolipidemic humans

American Journal of Clinical Nutrition ◽

10.1093/ajcn/33.12.2559 ◽

1980 ◽

Vol 33 (12) ◽

pp. 2559-2565 ◽

Cited By ~ 63

Author(s):

M H Tan ◽

M A Dickinson ◽

J J Albers ◽

R J Havel ◽

M C Cheung ◽

...

Keyword(s):

High Density Lipoprotein ◽

High Density Lipoprotein Cholesterol ◽

Saturated Fat ◽

Density Lipoprotein ◽

High Density ◽

Lipoprotein Cholesterol ◽

High Cholesterol ◽

Serum High Density Lipoprotein ◽

Apoprotein E

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Triglyceride to high density lipoprotein cholesterol ratio, total cholesterol to high density lipoprotein cholesterol ratio and low ankle brachial index in an elderly population

VASA ◽

10.1024/0301-1526/a000348 ◽

2014 ◽

Vol 43 (3) ◽

pp. 189-197 ◽

Cited By ~ 10

Author(s):

Yiqiang Zhan ◽

Jinming Yu ◽

Rongjing Ding ◽

Yihong Sun ◽

Dayi Hu

Keyword(s):

High Density Lipoprotein ◽

Total Cholesterol ◽

High Density Lipoprotein Cholesterol ◽

Ankle Brachial Index ◽

Density Lipoprotein ◽

High Density ◽

Lipoprotein Cholesterol ◽

Lipid Lowering ◽

Cholesterol Ratio ◽

Potential Biomarker

Background: The associations of triglyceride (TG) to high-density lipoprotein cholesterol ratio (HDL‑C) and total cholesterol (TC) to HDL‑C ratio and low ankle brachial index (ABI) were seldom investigated. Patients and methods: A population based cross-sectional survey was conducted and 2982 participants 60 years and over were recruited. TG, TC, HDL‑C, and low-density lipoprotein cholesterol (LDL-C) were assessed in all participants. Low ABI was defined as ABI ≤ 0.9 in either leg. Multiple logistic regression models were applied to study the association between TG/HDL‑C ratio, TC/HDL‑C ratio and low ABI. Results: The TG/HDL‑C ratios for those with ABI > 0.9 and ABI ≤ 0.9 were 1.28 ± 1.20 and 1.48 ± 1.13 (P < 0.0001), while the TC/HDL‑C ratios were 3.96 ± 1.09 and 4.32 ± 1.15 (P < 0.0001), respectively. After adjusting for age, gender, body mass index, obesity, current drinking, physical activity, hypertension, diabetes, lipid-lowering drugs, and cardiovascular disease history, the odds ratios (ORs) with 95 % confidence intervals (CIs) of low ABI for TG/HDL‑C ratio and TC/HDL‑C ratio were 1.10 (0.96, 1.26) and 1.34 (1.14, 1.59) in non-smokers. When TC was further adjusted, the ORs (95 % CIs) were 1.40 (0.79, 2.52) and 1.53 (1.21, 1.93) for TG/HDL‑C ratio and TC/HDL‑C ratio, respectively. Non-linear relationships were detected between TG/HDL‑C ratio and TC/HDL‑C ratio and low ABI in both smokers and non-smokers. Conclusions: TC/HDL‑C ratio was significantly associated with low ABI in non-smokers and the association was independent of TC, TG, HDL‑C, and LDL-C. TC/HDL‑C might be considered as a potential biomarker for early peripheral arterial disease screening.

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