Dose response relationship in local radiotherapy for hepatocellular carcinoma

2001 ◽  
Vol 51 (3) ◽  
pp. 257-258 ◽  
Author(s):  
H.C. Park ◽  
J. Seong ◽  
K.H. Han ◽  
C.Y. Chon ◽  
Y.M. Moon ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dose Response ◽  
Response Relationship ◽  
Dose Response Relationship

Dose-response relationship in local radiotherapy for hepatocellular carcinoma

2002 ◽  
Vol 54 (1) ◽  
pp. 150-155 ◽  
Author(s):  
Hee Chul Park ◽  
Jinsil Seong ◽  
Kwang Hyub Han ◽  
Chae Yoon Chon ◽  
Young Myoung Moon ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dose Response ◽  
Response Relationship ◽  
Dose Response Relationship

scholarly journals Dose–Response Between Serum Prealbumin and All-Cause Mortality After Hepatectomy in Patients With Hepatocellular Carcinoma

2021 ◽  
Vol 10 ◽  
Author(s):  
Rong-Rui Huo ◽  
Hao-Tian Liu ◽  
Zhu-Jian Deng ◽  
Xiu-Mei Liang ◽  
Wen-Feng Gong ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dose Response ◽  
Proportional Hazards ◽  
Cox Model ◽  
Cox Proportional Hazards ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Hazard Ratios ◽  
All Cause Mortality ◽  
Z Scores

BackgroundThe relationship between serum prealbumin and the risk of all-cause mortality after hepatectomy in patients with hepatocellular carcinoma (HCC) needs to be evaluated.MethodsWe conducted a retrospective study. A Cox proportional hazards regression model was used to adjust for potential confounders. Prealbumin level was transformed by Z-scores and categorized into quartiles (Q1: <147 mg/L, Q2: 147–194 mg/L, Q3: 194–239 mg/L, Q4: >239 mg/L). We assessed the dose-response relationship between serum prealbumin and the risk of all-cause mortality using a restricted cubic spline model.ResultsData were included from 2,022 HCC patients who underwent hepatectomy at Guangxi Medical University Cancer Hospital in China between January 2006 and January 2016. The adjusted hazard ratios (HRs) for increasing quartiles of serum prealbumin were 0.78 [95% confidence interval (CI): 0.64–0.95] for Q2, 0.66 (0.53–0.81) for Q3, and 0.51 (0.41–0.64) for Q4 in the Cox model (all P < 0.001). Serum prealbumin showed an L-shaped, non-linear dose-response relationship with the risk of all-cause mortality (P < 0.001). Among patients whose serum prealbumin was below 250 mg/L, risk of all-cause mortality decreased by 27% (95% CI: 18–36%) per increase of one standard deviation (69.8 mg/L) in serum prealbumin.ConclusionsLevels of serum prealbumin under 250 mg/L may be considered dangerous with respect to all-cause mortality after hepatectomy in HCC patients. Serum prealbumin may be useful as a prognostic marker in HCC patients undergoing hepatectomy.

A SUBCUTANEOUS INJECTION ASSAY FOR ANTI-ANDROGENS IN THE CHICK

1962 ◽  
Vol 41 (2) ◽  
pp. 268-273 ◽  
Author(s):  
Ralph I. Dorfman
Keyword(s):  
Dose Response ◽  
Subcutaneous Injection ◽  
Response Relationship ◽  
Dose Response Relationship

ABSTRACT The stimulating action of testosterone on the chick's comb can be inhibited by the subcutaneous injection of 0.1 mg of norethisterone or Ro 2-7239 (2-acetyl-7-oxo-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydrophenanthrene), 0.5 mg of cortisol or progesterone, and by 4.5 mg of Mer-25 (1-(p-2-diethylaminoethoxyphenyl)-1-phenyl-2-p-methoxyphenyl ethanol). No dose response relationship could be established. Norethisterone was the most active anti-androgen by this test.

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