Randomized trial on the efficacy of radiotherapy for cerebral low-grade glioma in the adult: European Organization for Research and Treatment of Cancer Study 22845 with the Medical Research Council study BRO4: an interim analysis

2002 ◽  
Vol 52 (2) ◽  
pp. 316-324 ◽  
Author(s):  
Abul B.M.F Karim ◽  
Denes Afra ◽  
Philippe Cornu ◽  
Norman Bleehan ◽  
Simon Schraub ◽  
...  
Keyword(s):  
Medical Research ◽  
Randomized Trial ◽  
Interim Analysis ◽  
Research Council ◽  
Medical Research Council ◽  
Low Grade Glioma ◽  
Low Grade ◽  
European Organization ◽  
Cancer Study

Quality of Life in Good Prognosis Patients With Metastatic Germ Cell Cancer: A Prospective Study of the European Organization for Research and Treatment of Cancer Genitourinary Group/Medical Research Council Testicular Cancer Study Group (30941/TE20)

2003 ◽  
Vol 21 (6) ◽  
pp. 1107-1118 ◽  
Author(s):  
Sophie D. Fosså ◽  
Ronald de Wit ◽  
J. Trevor Roberts ◽  
Peter M. Wilkinson ◽  
Pieter H.M. de Mulder ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Testicular Cancer ◽  
Medical Research ◽  
Clinical Relevance ◽  
Research Council ◽  
Medical Research Council ◽  
European Organization ◽  
Increased Risk ◽  
Gi Toxicity

Purpose: To describe global quality of life (GLQL) in patients with metastatic testicular cancer (TC) treated with four different schedules of bleomycin, etoposide, and cisplatin (BEP) chemotherapy (four v three cycles given over 5 v 3 days). Patients and Methods: Quality-of-life data were prospectively collected in 666 patients with metastatic TC entered into the European Organization for Research and Treatment of Cancer (EORTC) Trial 30941/United Kingdom Medical Research Council Trial TE20, using the EORTC Quality-of-Life Questionnaire C30 and a TC module. Data were analyzed by a mixed effects model and by evaluation of clinically relevant changes at 2 years. Results: The pattern of GLQL changes was similar in the four groups. Two years after chemotherapy, 36% of patients displayed improved GLQL as compared with baseline, whereas GLQL had deteriorated in 13%. At 3 months, patients receiving the 3-day regimen experienced increased gastrointestinal (GI) toxicity more than those receiving the 5-day regimen, with the difference reaching the level of clinical relevance (≥ 10-point change) if four cycles were given. The 3-day schedule increased the 2-year risk of tinnitus, with clinical relevance demonstrated after four cycles. Long-term peripheral neuropathy and Raynaud-like phenomena were not associated with the number of cycles or days per cycle. At 2 years, Raynaud-like phenomena, tinnitus, or reduced hearing were reported by 21% to 26% of the patients. Conclusion: Because of the excess of acute GI toxicity and the increased risk of tinnitus after the 3-day regimen, we recommend the 5-day regimen if four cycles of BEP are planned. If only three cycles are to be given, then the 3-day regimen is acceptable, even given the increased risk of nausea/vomiting at 3 months.

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