African trypanosomiasis in the rat alters melatonin secretion and melatonin receptor binding in the suprachiasmatic nucleus

1998 ◽  
Vol 47 (3) ◽  
pp. 265-269 ◽  
Author(s):  
Krister Kristensson ◽  
Bruno Claustrat ◽  
Jama D.M Mhlanga ◽  
Morten Møller
Keyword(s):  
Suprachiasmatic Nucleus ◽  
Receptor Binding ◽  
African Trypanosomiasis ◽  
Melatonin Receptor ◽  
Melatonin Secretion

Responsiveness to melatonin and its receptor expression in the aging circadian clock of mice

1997 ◽  
Vol 273 (6) ◽  
pp. R1855-R1860 ◽  
Author(s):  
Susan Benloucif ◽  
Monica I. Masana ◽  
Margarita L. Dubocovich
Keyword(s):  
Suprachiasmatic Nucleus ◽  
Phase Shifts ◽  
Receptor Expression ◽  
Circadian Activity ◽  
Melatonin Receptor ◽  
Activity Rhythms ◽  
Age Related ◽  
Melatonin Administration ◽  
Timing System ◽  
Circadian Timing System

This study determined the effect of age on the efficacy of melatonin treatment to phase shift circadian activity rhythms and on melatonin receptor expression in the suprachiasmatic nucleus (SCN) and paraventricular nucleus of the thalamus (PVNT) of C3H/HeN mice. The circadian rhythm of 2-[125I]iodomelatonin binding, assessed at three times of the day [circadian times (CT) 2, 10, and 18], showed a modest age-related decrease in the SCN but not the PVNT of old C3H/HeN mice (24 mo). There was a tendency for age to reduce Mel1a melatonin receptor mRNA expression in the suprachiasmatic nucleus during the day, but not during the night. The magnitude of phase shifts of circadian activity rhythms (advances or delays) induced by administration of melatonin at CT 10 or CT 2 was identical in young and old C3H/HeN mice. Together, these results suggest that the decrease in melatonin receptor expression in the SCN had little effect on melatonin-induced phase shifts of circadian activity rhythms. We conclude that the responsiveness of the circadian timing system to melatonin administration does not decrease with age.

Decreased MT1 melatonin receptor expression in the suprachiasmatic nucleus in aging and Alzheimer's disease

2007 ◽  
Vol 28 (8) ◽  
pp. 1239-1247 ◽  
Author(s):  
Ying-Hui Wu ◽  
Jiang-Ning Zhou ◽  
Joop Van Heerikhuize ◽  
Ralf Jockers ◽  
Dick F. Swaab
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Suprachiasmatic Nucleus ◽  
Receptor Expression ◽  
Melatonin Receptor ◽  
Mt1 Melatonin Receptor

NMDA receptor binding in rodent suprachiasmatic nucleus

1994 ◽  
Vol 640 (1-2) ◽  
pp. 113-118 ◽  
Author(s):  
Morri D. Hartgraves ◽  
Jannon L. Fuchs
Keyword(s):  
Nmda Receptor ◽  
Suprachiasmatic Nucleus ◽  
Receptor Binding ◽  
Nmda Receptor Binding
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