Characterization of the promoter region and genomic organization of GLI; a member of the Sonic hedgehog-Patched signaling pathway

Gene ◽  
1998 ◽  
Vol 209 (1-2) ◽  
pp. 1-11 ◽  
Author(s):  
Cheng Zheng Liu ◽  
Jian Tao Yang ◽  
Joon Won Yoon ◽  
David Walterhouse ◽  
Philip Iannaccone
Keyword(s):  
Signaling Pathway ◽  
Sonic Hedgehog ◽  
Promoter Region ◽  
Genomic Organization

scholarly journals Genomic organization and characterization of the promoter region of the round-spotted pufferfish (Tetraodon fluviatilis) JAK1 kinase gene

1998 ◽  
Vol 1395 (1) ◽  
pp. 50-56 ◽  
Author(s):  
Jiann-Horng Leu ◽  
Mau-Sun Chang ◽  
Chen-Wen Yao ◽  
Chen-Kung Chou ◽  
Shui-Tsung Chen ◽  
...  
Keyword(s):  
Promoter Region ◽  
Genomic Organization ◽  
Kinase Gene

Genomic organization and characterization of the promoter region of murine GSTM2 gene

Gene ◽  
2001 ◽  
Vol 270 (1-2) ◽  
pp. 221-229 ◽  
Author(s):  
Atul Kumar ◽  
E.Premkumar Reddy
Keyword(s):  
Promoter Region ◽  
Genomic Organization

scholarly journals Characterization of the human pleiotrophin gene. Promoter region and chromosomal localization.

1992 ◽  
Vol 267 (36) ◽  
pp. 26011-26016 ◽  
Author(s):  
Y.S. Li ◽  
R.M. Hoffman ◽  
M.M. Le Beau ◽  
R Espinosa ◽  
N.A. Jenkins ◽  
...  
Keyword(s):  
Promoter Region ◽  
Chromosomal Localization ◽  
Gene Promoter ◽  
Gene Promoter Region

scholarly journals New Tricks for an Old (Hedge)Hog: Sonic Hedgehog Regulation of Astrocyte Function

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1353
Author(s):  
A. Denise R. Garcia
Keyword(s):  
Signaling Pathway ◽  
Sonic Hedgehog ◽  
Synapse Formation ◽  
Inflammatory Responses ◽  
Molecular Signaling ◽  
Synaptic Organization ◽  
Shh Signaling ◽  
Broad Array ◽  
And Function ◽  
Molecular Signaling Pathway

The Sonic hedgehog (Shh) molecular signaling pathway is well established as a key regulator of neurodevelopment. It regulates diverse cellular behaviors, and its functions vary with respect to cell type, region, and developmental stage, reflecting the incredible pleiotropy of this molecular signaling pathway. Although it is best understood for its roles in development, Shh signaling persists into adulthood and is emerging as an important regulator of astrocyte function. Astrocytes play central roles in a broad array of nervous system functions, including synapse formation and function as well as coordination and orchestration of CNS inflammatory responses in pathological states. Neurons are the source of Shh in the adult, suggesting that Shh signaling mediates neuron–astrocyte communication, a novel role for this multifaceted pathway. Multiple roles for Shh signaling in astrocytes are increasingly being identified, including regulation of astrocyte identity, modulation of synaptic organization, and limitation of inflammation. This review discusses these novel roles for Shh signaling in regulating diverse astrocyte functions in the healthy brain and in pathology.

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