Assessment of the toxic effects of 2-dodecanone in the insect model species Drosophila melanogaster

2021 ◽  
Vol 350 ◽  
pp. S182
Author(s):  
M. Aquilino ◽  
R. Planelló ◽  
L. LLorente ◽  
D. Siaussat ◽  
Ó. Herrero
Keyword(s):  
Drosophila Melanogaster ◽  
Toxic Effects ◽  
Model Species

scholarly journals FlyRNAi.org—the database of the Drosophila RNAi screening center and transgenic RNAi project: 2021 update

2020 ◽  
Vol 49 (D1) ◽  
pp. D908-D915
Author(s):  
Yanhui Hu ◽  
Aram Comjean ◽  
Jonathan Rodiger ◽  
Yifang Liu ◽  
Yue Gao ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Functional Genomics ◽  
Protein Interactions ◽  
Protein Modification ◽  
Genetic Model ◽  
Online Resources ◽  
Model Species ◽  
Rnai Screening ◽  
Transcriptomics Data

Abstract The FlyRNAi database at the Drosophila RNAi Screening Center and Transgenic RNAi Project (DRSC/TRiP) provides a suite of online resources that facilitate functional genomics studies with a special emphasis on Drosophila melanogaster. Currently, the database provides: gene-centric resources that facilitate ortholog mapping and mining of information about orthologs in common genetic model species; reagent-centric resources that help researchers identify RNAi and CRISPR sgRNA reagents or designs; and data-centric resources that facilitate visualization and mining of transcriptomics data, protein modification data, protein interactions, and more. Here, we discuss updated and new features that help biological and biomedical researchers efficiently identify, visualize, analyze, and integrate information and data for Drosophila and other species. Together, these resources facilitate multiple steps in functional genomics workflows, from building gene and reagent lists to management, analysis, and integration of data.

Alpha-ketoglutarate attenuates toxic effects of sodium nitroprusside and hydrogen peroxide in Drosophila melanogaster

2015 ◽  
Vol 40 (2) ◽  
pp. 650-659 ◽  
Author(s):  
Maria M. Bayliak ◽  
Halyna V. Shmihel ◽  
Maria P. Lylyk ◽  
Oksana M. Vytvytska ◽  
Janet M. Storey ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Drosophila Melanogaster ◽  
Sodium Nitroprusside ◽  
Toxic Effects

scholarly journals Effects of tritiated water on locomotion of zebrafish larvae: a new insight in tritium toxic effects on a vertebrate model species

2020 ◽  
Vol 219 ◽  
pp. 105384
Author(s):  
Caroline Arcanjo ◽  
Christelle Adam-Guillermin ◽  
Sophia Murat El Houdigui ◽  
Giovanna Loro ◽  
Claire Della-Vedova ◽  
...  
Keyword(s):  
Tritiated Water ◽  
Toxic Effects ◽  
Model Species ◽  
Zebrafish Larvae ◽  
Vertebrate Model

scholarly journals Combined use of feature engineering and machine-learning to predict essential genes in Drosophila melanogaster

2020 ◽  
Vol 2 (3) ◽  
Author(s):  
Tulio L Campos ◽  
Pasi K Korhonen ◽  
Andreas Hofmann ◽  
Robin B Gasser ◽  
Neil D Young
Keyword(s):  
Machine Learning ◽  
Drosophila Melanogaster ◽  
Molecular Mechanisms ◽  
Deep Understanding ◽  
Computational Prediction ◽  
Essential Genes ◽  
Model Species ◽  
Combined Use ◽  
Vinegar Fly ◽  
Computational Predictions

Abstract Characterizing genes that are critical for the survival of an organism (i.e. essential) is important to gain a deep understanding of the fundamental cellular and molecular mechanisms that sustain life. Functional genomic investigations of the vinegar fly, Drosophila melanogaster, have unravelled the functions of numerous genes of this model species, but results from phenomic experiments can sometimes be ambiguous. Moreover, the features underlying gene essentiality are poorly understood, posing challenges for computational prediction. Here, we harnessed comprehensive genomic-phenomic datasets publicly available for D. melanogaster and a machine-learning-based workflow to predict essential genes of this fly. We discovered strong predictors of such genes, paving the way for computational predictions of essentiality in less-studied arthropod pests and vectors of infectious diseases.

Sensitivity differences displayed by drosophila melanogaster larvae of different ages to the toxic effects of growth on media containing aflatoxin B1

1979 ◽  
Vol 24 (3) ◽  
pp. 373-380 ◽  
Author(s):  
Joseph P. Chinnici ◽  
Linda Erlanger ◽  
Marian Charnock ◽  
Margaret Jones ◽  
Janis Stein
Keyword(s):  
Drosophila Melanogaster ◽  
Aflatoxin B1 ◽  
Toxic Effects ◽  
Different Ages

scholarly journals Toxic Effects of Chronic Feeding with Food Azo Dyes on Drosophila melanogaster Oregon R

2017 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Handan Uysal ◽  
Sıdıka Genç ◽  
Arif Ayar
Keyword(s):  
Drosophila Melanogaster ◽  
Azo Dyes ◽  
Toxic Effects

scholarly journals Osmoregulation in Drosophila melanogaster selected for urea tolerance

1999 ◽  
Vol 202 (17) ◽  
pp. 2349-2358 ◽  
Author(s):  
V.A. Pierce ◽  
L.D. Mueller ◽  
A.G. Gibbs
Keyword(s):  
Amino Acids ◽  
Drosophila Melanogaster ◽  
Toxic Effects ◽  
Physiological Adaptation ◽  
Organic Osmolytes ◽  
Per Se ◽  
Body Compartments ◽  
And Control

Animals may adapt to hyperosmolar environments by either osmoregulating or osmoconforming. Osmoconforming animals generally accumulate organic osmolytes including sugars, amino acids or, in a few cases, urea. In the latter case, they also accumulate ‘urea-counteracting’ solutes to mitigate the toxic effects of urea. We examined the osmoregulatory adaptation of Drosophila melanogaster larvae selected to live in 300 mmol l(−)(1) urea. Larvae are strong osmoregulators in environments with high NaCl or sucrose levels, but have increased hemolymph osmolarity on urea food. The increase in osmolarity on urea food is smaller in the selected larvae relative to unselected control larvae, and their respective hemolymph urea concentrations can account for the observed increases in total osmolarity. No other hemolymph components appear to act as urea-counteractants. Urea is calculated to be in equilibrium across body compartments in both selected and control larvae, indicating that the selected larvae are not sequestering it to lower their hemolymph osmolarity. The major physiological adaptation to urea does not appear to involve increased tolerance or improved osmoregulation per se, but rather mechanisms (e.g. metabolism, decreased uptake or increased excretion) that reduce overall urea levels and the consequent toxicity.

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