Toxic effects of gentamicin in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg9

2014 ◽  
Vol 3 (3) ◽  
pp. 168 ◽  
Author(s):  
Rahul ◽  
Smita Jyoti ◽  
Falaq Naz ◽  
Yasir Hasan Siddique
Keyword(s):  
Drosophila Melanogaster ◽  
Toxic Effects ◽  
The Third ◽  
Transgenic Drosophila ◽  
Third Instar Larvae

scholarly journals Protective role of curcumin against the toxic effects of cyclophosphamide in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg9

2012 ◽  
Vol 2 (1) ◽  
pp. 2 ◽  
Author(s):  
Yasir Hasan Siddique
Keyword(s):  
Drosophila Melanogaster ◽  
Tissue Damage ◽  
Protective Role ◽  
Toxic Effects ◽  
Hsp70 Expression ◽  
The Third ◽  
Dose Dependent ◽  
Transgenic Drosophila ◽  
Third Instar Larvae

In the present study the effects of curcumin was studied against the toxic effects induced by 0.025 and 0.050 ml/ml of cyclophosphamide (CP) in the third instar larvae of transgenic <em>Drosophila melanogaster (hsp70-lacZ)Bg9</em> using hsp70 expression and dye exclusion test as a parameter. The exposure of the third instar larvae to 0.025ml/ml of CP along with 1, 5 and 10 mg/ml of curcumin results in the dose dependent significant decrease in the <em>hsp70</em> expression and tissue damage for 12, 24 and 48hr of duration. Similar results were obtained with the exposure of third instar larvae to 0.050 ml/ml of CP along with 1, 5 and 10 mg/ml of curcumin. The selected doses of curcumin i.e. 1, 5 and 10 mg/ml were not toxic but reduced significantly the expression of <em>hsp70</em> and tissue damage induced by CP. The results of the present study suggest that the curcumin has a protective role against the toxic effects of CP in the third instar larvae of transgenic <em>Drosophila melanogaster (hsp70-lacZ)Bg9</em>.

scholarly journals Evaluation of the toxic potential of arecoline toward the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ) Bg9

2018 ◽  
Vol 7 (3) ◽  
pp. 432-443 ◽  
Author(s):  
Barkha Shakya ◽  
Yasir Hasan Siddique
Keyword(s):  
Drosophila Melanogaster ◽  
Areca Nut ◽  
Carcinogenic Agent ◽  
The Third ◽  
Toxic Potential ◽  
Transgenic Drosophila ◽  
Third Instar Larvae

Arecoline is the key component of areca nut and has been suggested as a carcinogenic agent.

scholarly journals Evaluation of the Toxic Potential of Graphene Copper Nanocomposite (GCNC) in the Third Instar Larvae of Transgenic Drosophila melanogaster (hsp70-lacZ)Bg9

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e80944 ◽  
Author(s):  
Yasir Hasan Siddique ◽  
Ambreen Fatima ◽  
Smita Jyoti ◽  
Falaq Naz ◽  
Rahul ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
The Third ◽  
Toxic Potential ◽  
Transgenic Drosophila ◽  
Third Instar Larvae

Effect of alloxan on the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg9

Toxin Reviews ◽  
2018 ◽  
Vol 39 (1) ◽  
pp. 41-51 ◽  
Author(s):  
Yasir Hasan Siddique ◽  
Mohd. Saifullah Ansari ◽  
Rahul ◽  
Smita Jyoti
Keyword(s):  
Drosophila Melanogaster ◽  
The Third ◽  
Transgenic Drosophila ◽  
Third Instar Larvae

scholarly journals Protective role of Plumbago zeylanica extract against the toxic effects of ethinylestradiol in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg9 and cultured human peripheral blood lymphocytes

2011 ◽  
Vol 1 (1) ◽  
pp. 7 ◽  
Author(s):  
Yasir Hasan Siddique ◽  
Gulshan Ara ◽  
Mohammad Faisal ◽  
Mohammad Afzal
Keyword(s):  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Toxic Effects ◽  
Hsp70 Expression ◽  
Blood Lymphocytes ◽  
The Third ◽  
Human Peripheral Blood Lymphocytes ◽  
Transgenic Drosophila ◽  
Third Instar Larvae

In the present study the effects of Plumbago zeylanica extract were studied against the toxic effects induced by 10 μM of ethinylestradiol in cultured human peripheral blood lymphocytes using chromosomal aberrations as a parameter and in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg9 (by 0.50 and 1.0 μl/mL of ethinylestradiol) using hsp70 expression as a parameter. The selected doses of P. zeylanica extract i.e. 1.075x10–4, 2.125x10–4, 3.15x10–4 and 4.17x10–4 g/mL were not toxic but were potent enough to reduce significantly the toxic effects induced by ethinylestradiol in cultured human peripheral blood lymphocytes. The selected doses for the estimation of hsp70 expression in the third instar larvae of transgenic D. melanogaster (hsp70-lacZ) Bg9. i.e. 1, 2, 4 and 6 µl/mL were not toxic though reduced significantly the expression of hsp70 induced by 0.5 and1.0 µl/mL of ethinylestradiol.

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