Investigation of pectin as a carrier for oral delivery of proteins using calcium pectinate gel beads

1998 ◽  
Vol 169 (2) ◽  
pp. 213-220 ◽  
Author(s):  
P Sriamornsak
Keyword(s):  
Oral Delivery ◽  
Gel Beads ◽  
Calcium Pectinate

scholarly journals Effect of Drug Loading Method on Drug Content and Drug Release from Calcium Pectinate Gel Beads

2010 ◽  
Vol 11 (3) ◽  
pp. 1315-1319 ◽  
Author(s):  
Pornsak Sriamornsak ◽  
Jurairat Nunthanid ◽  
Kamonrak Cheewatanakornkool ◽  
Somkamol Manchun
Keyword(s):  
Drug Release ◽  
Drug Loading ◽  
Drug Content ◽  
Loading Method ◽  
Gel Beads ◽  
Calcium Pectinate

scholarly journals Mechanical characterization of calcium pectinate hydrogel for controlled drug delivery

2003 ◽  
Vol 57 (12) ◽  
pp. 611-616 ◽  
Author(s):  
Jin Chung ◽  
Zhang Zhibing
Keyword(s):  
Mechanical Properties ◽  
Drug Release ◽  
Oral Delivery ◽  
Drug Carrier ◽  
Release Profile ◽  
Water Soluble ◽  
Drug Release Profile ◽  
Force Relaxation ◽  
Calcium Pectinate ◽  
Model Drug

Calcium pectinate beads, a paniculate hydrogel system, is an attractive drug carrier for oral delivery. In this study, a poorly water-soluble model drug indomethacin was incorporated into calcium pectinate beads made of different pectin concentrations, which were produced by an extrusion method. The effect of pectin concentration on bead size, circularity, swelling behavior, and mechanical properties, as well as in vitro drug release profile was investigated. The mechanical properties of calcium pectinate beads were determined by a micromanipulation technique. The drug release profile was measured using a standard British Pharmacopoeia method. It was found that the beads made of higher pectin concentration in general had a less permeable matrix structure and greater mechanical rigidity, although they swelled more after hydration. However, such an effect was not significant when the pectin concentration was increased to above 8%. Micromanipulation measurements showed that there was significant relaxation of the force being imposed on single hydrated beads when they were held, but this phenomenon did not occur on dry beads, which means that the force relaxation was dominated by liquid loss from the beads. The rate of the force relaxation was determined, and has been related to the release rate of the model drug entrapped in the calcium pectinate beads.

scholarly journals Morphology and buoyancy of oil-entrapped calcium pectinate gel beads

2004 ◽  
Vol 6 (3) ◽  
pp. 65-71 ◽  
Author(s):  
Pornsak Sriamornsak ◽  
Nartaya Thirawong ◽  
Satit Puttipipatkhachorn
Keyword(s):  
Gel Beads ◽  
Calcium Pectinate

Swelling and morphology of calcium pectinate gel beads obtained from Silene vulgaris callus modified pectins

2014 ◽  
Vol 103 ◽  
pp. 550-557 ◽  
Author(s):  
Elena A. Günter ◽  
Oxana V. Popeyko ◽  
Pavel A. Markov ◽  
Ekaterina A. Martinson ◽  
Sergey G. Litvinets ◽  
...  
Keyword(s):  
Silene Vulgaris ◽  
Gel Beads ◽  
Calcium Pectinate
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