Effects of caloric restriction and aging on the auditory function of rhesus monkeys (Macaca mulatta): The University of Wisconsin Study

2002 ◽  
Vol 169 (1-2) ◽  
pp. 24-35 ◽  
Author(s):  
Cynthia G Fowler ◽  
Peter Torre ◽  
Joseph W Kemnitz
Keyword(s):  
Caloric Restriction ◽  
Macaca Mulatta ◽  
Rhesus Monkeys ◽  
Auditory Function ◽  
University Of Wisconsin ◽  
The University

scholarly journals Caloric restriction increases HDL2levels in rhesus monkeys (Macaca mulatta)

1997 ◽  
Vol 273 (4) ◽  
pp. E714-E719 ◽  
Author(s):  
Roy B. Verdery ◽  
Donald K. Ingram ◽  
George S. Roth ◽  
Mark A. Lane
Keyword(s):  
Caloric Restriction ◽  
Macaca Mulatta ◽  
Rhesus Monkeys ◽  
Human Life ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Insulin Level ◽  
Weight Percent ◽  
Calorie Intake ◽  
Age Cohorts

Caloric restriction (CR) prolongs the life of rodents and other small animals, but the benefits of CR for primates and people are as yet unknown, and mechanisms by which CR may slow aging remain unidentified. A study of rhesus monkeys, Macaca mulatta, is underway to determine if CR might prolong life span in primates and to evaluate potential mechanisms for life prolongation. Thirty rhesus monkeys in three age cohorts, restricted to 70% of ad libitum calorie intake for 6–7 yr, were compared with 30 controls. Plasma lipid, lipoprotein, and high-density lipoprotein (HDL) apolipoproteins and subfractions were measured and compared with weight, percent fat, glucose, and insulin level. CR caused decreased triglyceride levels in adult monkeys and increased levels of HDL2b, the HDL subfraction associated with protection from atherosclerosis. Multivariate statistical analyses showed that differences in lipid and lipoprotein levels occurring with CR could be accounted for, at least in part, by decreased body mass and improved glucose regulation. These studies have used a novel dietary modification paradigm in nonhuman primates focused on calorie reduction. Results suggest that CR, as mediated by its beneficial effect on body composition and glucose metabolism, could prolong human life by decreasing the incidence of atherosclerosis.

scholarly journals Auditory function in rhesus monkeys: Effects of aging and caloric restriction in the Wisconsin monkeys five years later

2010 ◽  
Vol 261 (1-2) ◽  
pp. 75-81 ◽  
Author(s):  
Cynthia G. Fowler ◽  
Kirstin Beach Chiasson ◽  
Tami Hanson Leslie ◽  
Denise Thomas ◽  
T. Mark Beasley ◽  
...  
Keyword(s):  
Caloric Restriction ◽  
Rhesus Monkeys ◽  
Auditory Function ◽  
Effects Of Aging

Assessment of auditory function in rhesus monkeys (Macaca mulatta): effects of age and calorie restriction

2004 ◽  
Vol 25 (7) ◽  
pp. 945-954 ◽  
Author(s):  
Peter Torre ◽  
Julie A Mattison ◽  
Cynthia G Fowler ◽  
Mark A Lane ◽  
George S Roth ◽  
...  
Keyword(s):  
Calorie Restriction ◽  
Macaca Mulatta ◽  
Rhesus Monkeys ◽  
Auditory Function

EFFECT OF CORTICOTROPHIN ON CORTISOL SECRETION IN CASTRATED RHESUS MONKEYS

1978 ◽  
Vol 79 (2) ◽  
pp. 247-248
Author(s):  
C. F. FARVER ◽  
D. DE WIED ◽  
P. T. K. TOIVOLA
Keyword(s):  
Macaca Mulatta ◽  
Rhesus Monkeys ◽  
Plasma Cortisol ◽  
Physical Restraint ◽  
Regional Primate Research ◽  
Primate Research ◽  
Cortisol Secretion ◽  
University Of Wisconsin ◽  
Number Of Factors ◽  
Experimental Subjects

Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53706, U.S.A. (Received 22 May 1978) In a wide variety of species corticotrophin (ACTH) is known to stimulate the synthesis and secretion of adrenocortical steroids. Studies with rhesus monkeys have shown that these responses can be affected by a number of factors including the method of handling and the type of physical restraint (Mason, 1959). In addition, androgens may depress plasma levels of glucocorticoids in primates (Brown & Migeon, 1956; Huis in't Veld, Louwerens & van den Spek, 1960). It was therefore decided to study the response of plasma cortisol to ACTH without these neural or hormonal influences. This report describes the effects of ACTH on castrated rhesus monkeys adapted to chronic restraint. Four chair-restrained, orchidectomized rhesus monkeys (Macaca mulatta) bearing chronic indwelling venous catheters were used as experimental subjects and were housed, maintained and subjected to blood sampling as

Dietary restriction and aging in rhesus monkeys: the University of Wisconsin study

2000 ◽  
Vol 35 (9-10) ◽  
pp. 1131-1149 ◽  
Author(s):  
J.J Ramsey ◽  
R.J Colman ◽  
N.C Binkley ◽  
J.D Christensen ◽  
T.A Gresl ◽  
...  
Keyword(s):  
Dietary Restriction ◽  
Rhesus Monkeys ◽  
University Of Wisconsin ◽  
The University

Some Biological Applications of High Voltage Electron Microscopy

1974 ◽  
Vol 32 ◽  
pp. 298-299
Author(s):  
Hans Ris
Keyword(s):  
High Voltage ◽  
Chromosome Structure ◽  
Nerve Fibers ◽  
Good Resolution ◽  
High Voltage Electron Microscopy ◽  
Voltage Electron ◽  
University Of Wisconsin ◽  
High Voltage Electron ◽  
One Year ◽  
The University

The High Voltage Electron Microscope Laboratory at the University of Wisconsin has been in operation a little over one year. I would like to give a progress report about our experience with this new technique. The achievement of good resolution with thick specimens has been mainly exploited so far. A cold stage which will allow us to look at frozen specimens and a hydration stage are now being installed in our microscope. This will soon make it possible to study undehydrated specimens, a particularly exciting application of the high voltage microscope.Some of the problems studied at the Madison facility are: Structure of kinetoplast and flagella in trypanosomes (J. Paulin, U. of Georgia); growth cones of nerve fibers (R. Hannah, U. of Georgia Medical School); spiny dendrites in cerebellum of mouse (Scott and Guillery, Anatomy, U. of Wis.); spindle of baker's yeast (Joan Peterson, Madison) spindle of Haemanthus (A. Bajer, U. of Oregon, Eugene) chromosome structure (Hans Ris, U. of Wisconsin, Madison). Dr. Paulin and Dr. Hanna are reporting their work separately at this meeting and I shall therefore not discuss it here.

Ultrastructural characteristics of sporidia of Ustilago

1989 ◽  
Vol 47 ◽  
pp. 786-787
Author(s):  
Patricia N. Hackney
Keyword(s):  
Electron Microscope ◽  
Type System ◽  
Tube Formation ◽  
High Voltage Electron Microscopy ◽  
Voltage Electron ◽  
University Of Wisconsin ◽  
Transmission Electron ◽  
Ustilago Hordei ◽  
Silene Alba ◽  
The University

Ustilago hordei and Ustilago violacea are yeast-like basidiomycete pathogens ofHordeum vulgare and Silene alba respectively. The mating type system in both species of Ustilago is bipolar, with alleles, A,a, (U.hordei) and a1, a2 (U.violacea) at a single locus. Haploid sporidia maintain the asexual phase by budding, while the sexual phase is initiated by conjugation tube formation between the mating types during budding and conjugation.For observation of budding, sporidia were prepared by culturing the four types on YEG (yeast extract glucose) broth for 24 hours. After centrifugation at 5000g cells were either left unmated or mated in a1/a2,A/a combinations. The sporidia were then mixed 1:1 with 4% agar and the resulting 1mm cubes fixed in 8% gluteraldehyde and post fixed in osmium tetroxide. After dehydration and embedding cubes were thin sectioned with a LKB ultratome and photographed in a Zeiss 9s transmission electron microscope or in an AE1 electron microscope of MK11 1MEV at the High Voltage Electron Microscopy Center of the University of Wisconsin-Madison.

Sign in / Sign up

Export Citation Format

Share Document