Small cell carcinoma of the larynx: imaging findings

Abstract Primary laryngeal carcinomas comprise approximately 2% to 5% of all malignancies worldwide. Of these laryngeal carcinomas, approximately 99% are primary squamous cell carcinomas. During the past 30 years, about 160 cases of primary small cell carcinoma of the larynx have been reported. Combined primary squamous and small cell carcinoma of the larynx, the so-called composite tumor of the larynx, is even more rare, with only 13 published cases to date. Although the major risk factors for developing these composite tumors of the larynx are thought to be similar to other more common neoplasms of the larynx, such as squamous cell carcinoma, the treatment and prognosis are different. We report an additional case of combined small cell carcinoma of the larynx and discuss the histogenesis of this unusual neoplasm.

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Primary small cell carcinoma of the larynx. Survival time of 47 months. Case report

Annals of Medicine and Surgery ◽

10.1016/j.amsu.2018.04.031 ◽

2018 ◽

Vol 30 ◽

pp. 46-49 ◽

Cited By ~ 1

Author(s):

A. Raposo ◽

A. Marco ◽

M.E. García-Solano ◽

M.J. Martínez-Ortiz ◽

F. García-Purriños ◽

...

Keyword(s):

Case Report ◽

Cell Carcinoma ◽

Survival Time ◽

Small Cell Carcinoma ◽

Small Cell ◽

Carcinoma Of The Larynx

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Small Cell Carcinoma of the Larynx: A Case Report

Otolaryngology ◽

10.1016/j.otohns.2005.03.078 ◽

2005 ◽

Vol 133 (4) ◽

pp. 647-647 ◽

Cited By ~ 4

Author(s):

Ossama Hamid ◽

Lobna El Fiky ◽

Lobna Ezz El Arab ◽

Yasser El Beltagy ◽

Ragaa Amin

Keyword(s):

Case Report ◽

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Small Cell ◽

Carcinoma Of The Larynx

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Neuro-endocrine tumours of the head and neck

The Journal of Laryngology & Otology ◽

10.1017/s0022215100113015 ◽

1990 ◽

Vol 104 (6) ◽

pp. 504-507 ◽

Cited By ~ 22

Author(s):

A. C. Soussi ◽

A. Benghiat ◽

C. S. Holgate ◽

B. Majumdar

Keyword(s):

Cell Carcinoma ◽

Head And Neck ◽

Small Cell Carcinoma ◽

Neuroendocrine Carcinoma ◽

Large Cell Carcinoma ◽

Large Cell ◽

Differential Response ◽

Small Cell ◽

Endocrine Tumours ◽

Carcinoma Of The Larynx

AbstractWe report two types of neuroendocrine carcinoma of the head and neck, small cell carcinoma of the ethmoid and large cell carcinoma of the larynx, demonstrating a differential response to radiotherapy.

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Primary, combined, atypical carcinoid and squamous cell carcinoma of the larynx: a new variety of composite tumour

The Journal of Laryngology & Otology ◽

10.1017/s0022215109991228 ◽

2009 ◽

Vol 124 (2) ◽

pp. 226-229 ◽

Cited By ~ 20

Author(s):

C R Davies-Husband ◽

P Montgomery ◽

D Premachandra ◽

H Hellquist

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Small Cell Carcinoma ◽

Squamous Cell ◽

Small Cell ◽

Neuroendocrine Neoplasms ◽

Atypical Carcinoid ◽

Typical Carcinoid ◽

First Case ◽

Carcinoma Of The Larynx

AbstractObjective:We report the first case of a laryngeal composite tumour consisting of a squamous cell carcinoma combined with an atypical carcinoid.Methods:Case report and review of the literature concerning laryngeal composite tumours.Results:Primary laryngeal carcinoma is the most common malignancy of the upper aerodigestive tract. The vast majority are of the squamous cell type. Primary neuroendocrine neoplasms represent a rare, heterogeneous subset of laryngeal malignancies, comprising typical carcinoid, atypical carcinoid, small cell carcinoma and paraganglioma. Primary combined neuroendocrine and squamous cell carcinoma of the larynx is even more rarely encountered, with only 14 publications of this so-called composite tumour to date. In each case, the neuroendocrine component has been small cell carcinoma.Conclusion:The treatment of primary neoplasms comprising more than one histological type is tailored to the most biologically aggressive tumour. Accurate diagnosis of the histological nature of laryngeal composite tumours is imperative to ensure optimal therapy.

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