A validated LC method for the quantitative determination of celecoxib in pharmaceutical dosage forms and purity evaluation in bulk drugs

2000 ◽  
Vol 22 (6) ◽  
pp. 949-956 ◽  
Author(s):  
M.K Srinivasu ◽  
Ch.Lakshmi Narayana ◽  
D.Sreenivas Rao ◽  
G.Om Reddy
Keyword(s):  
Quantitative Determination ◽  
Dosage Forms ◽  
Pharmaceutical Dosage Forms ◽  
Purity Evaluation

Titrimetric and Spectrophotometric Determination of Acetylenic Hypnotics, Using Brominating Agents

1985 ◽  
Vol 68 (6) ◽  
pp. 1209-1212
Author(s):  
Mohamed I Walash ◽  
Mohamed S Rizk ◽  
Amina El-Brashy
Keyword(s):  
Quantitative Determination ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Titration ◽  
Dosage Forms ◽  
Pharmaceutical Dosage Forms ◽  
Pure Substances

Abstract Titrimetric and spectrophotometric titration methods are described for the quantitative determination of acetylenic hypnotics ethchlorvynol, ethinamate, and meparfynol carbamate as pure substances and in dosage forms. The methods involve the use of different brominating agents. A known excess of the reagent is added and, after the specified time, the residual reagent is determined iodometrically. These procedures permit semimicro determination (1-20 mg) of the drug. Recoveries ranged from 98.48 ± 0.76 to 102.74 ± 2.60%. The procedures have been successfully applied to pharmaceutical dosage forms; the results agree well with those for compendial methods.

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