Physicochemical compatibility between ketoprofen lysine salt injections (Artrosilene®) and pharmaceutical products frequently used for combined therapy by intravenous administration

2003 ◽  
Vol 32 (6) ◽  
pp. 1235-1241 ◽  
Author(s):  
Roberto Anacardio ◽  
Orietta Perilli ◽  
Sandro Bartolini ◽  
Marco M. Gentile ◽  
Pietro Mazzeo ◽  
...  
2005 ◽  
Vol 18 (4) ◽  
pp. 791-798 ◽  
Author(s):  
R. Anacardio ◽  
S. Bartolini ◽  
M.M. Gentile ◽  
M. Bagnasco ◽  
G. Carlucci

Ketoprofen lysine salt (Artrosilene®, injectable solution) is a non-steroidal anti-inflammatory agent frequently administered by slow intravenous infusion with portable elastomeric infusion systems in association regimen with other analgesic drugs. The aim of this study was to investigate the physicochemical compatibility between ketoprofen lysine salt (Artrosilene®, injectable solution) and other injectable drugs frequently used in association, such as tramadol hydrochloride, keterolac tromethamine and morphine hydrochloride, into the Infusor LV5, Baxter elastomeric infusion system. Physicochemical properties of drug mixture, including colour, clarity, pH and drug content were observed or measured by a reversed-phase HPLC method with UV detection, before and after (up to 7 days) mixing at room temperature and under light protection. The results obtained demonstrated the physicochemical compatibility of ketoprofen lysine salt (Artrosilene®, injectable solution) with all drug formulations at every tested mixing ratios into Baxer Infusor LV5 infusion devices.


Il Farmaco ◽  
2002 ◽  
Vol 57 (11) ◽  
pp. 925-930 ◽  
Author(s):  
Roberto Anacardio ◽  
Orietta Perilli ◽  
Federica Pagnanelli ◽  
Sandro Bartolini ◽  
Marco M. Gentile ◽  
...  

2004 ◽  
Vol 171 (4S) ◽  
pp. 493-494
Author(s):  
Haruhito Azuma ◽  
Shiro Takahara ◽  
Takashi Wada ◽  
Takeshi Sakamoto ◽  
Akihiko Okuyama ◽  
...  

JAMA ◽  
1967 ◽  
Vol 200 (10) ◽  
pp. 824-829 ◽  
Author(s):  
M. Davidov

2006 ◽  
Vol 34 (1) ◽  
pp. 31
Author(s):  
Heidi Splete
Keyword(s):  

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