ASSOCIATION OF CORONARY ARTERY DIAMETER ON NON CONTRAST CARDIAC COMPUTED TOMOGRAPHY WITH CORONARY ARTERY CALCIUM SCORES AND TRADITIONAL RISK FACTORS.

AbstractThis study aimed to evaluate the association between the atherogenic index of plasma (AIP), which has been suggested as a novel marker for atherosclerosis, and coronary artery calcification (CAC) progression according to the baseline coronary artery calcium score (CACS). We included 12,326 asymptomatic Korean adults who underwent at least two CAC evaluations from December 2012 to August 2016. Participants were stratified into four groups according to AIP quartiles, which were determined by the log of (triglyceride/high-density lipoprotein cholesterol). Baseline CACSs were divided into three groups: 0, 1 − 100, and > 100. CAC progression was defined as a difference ≥ 2.5 between the square roots (√) of the baseline and follow-up CACSs (Δ√transformed CACS). Annualized Δ√transformed CACS was defined as Δ√transformed CACS divided by the inter-scan period. During a mean 3.3-year follow-up period, the overall incidence of CAC progression was 30.6%. The incidences of CAC progression and annualized Δ√transformed CACS were markedly elevated with increasing AIP quartile in participants with baseline CACSs of 0 and 1 − 100, but not in those with a baseline CACS > 100. The AIP level was associated with the annualized Δ√transformed CACS in participants with baseline CACSs of 0 (β = 0.016; P < 0.001) and 1 − 100 (β = 0.035; P < 0.001), but not in those with baseline CACS > 100 (β = 0.032; P = 0.385). After adjusting for traditional risk factors, the AIP was significantly associated with CAC progression in those with baseline CACS ≤ 100. The AIP has value for predicting CAC progression in asymptomatic adults without heavy baseline CAC.

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Abstract 12059: High Cardiorespiratory Fitness is Associated With Larger Coronary Artery Diameters

Circulation ◽

10.1161/circ.130.suppl_2.12059 ◽

2014 ◽

Vol 130 (suppl_2) ◽

Author(s):

John Ho ◽

John Cannaday ◽

Carrie Finley ◽

Carolyn Barlow ◽

Wendy Wade ◽

...

Keyword(s):

Risk Factors ◽

Coronary Artery ◽

Cardiorespiratory Fitness ◽

Linear Trend ◽

Calcium Score ◽

High Fitness ◽

Exercise Treadmill ◽

Coronary Artery Diameter ◽

Traditional Risk Factors ◽

The Right

Introduction: Cardiorespiratory fitness is inversely associated with morbidity and mortality even after adjustment for traditional risk factors. The biological mechanism for the protective effect of high fitness is largely unknown. Hypothesis: We hypothesized that high fitness would be associated with larger coronary artery diameters independent of traditional risk factors. Methods: In this study, 500 men with a coronary artery calcium score (CACS) < 10 were evaluated, with 100 from each age-adjusted fitness quintile (very poor, 1-20%; poor, 21-39%; fair, 40-59%; good, 60-79%; and excellent, 80-100%). Each participant had undergone fitness assessment with an exercise treadmill test on the day of CACS. Blinded to the fitness category, one of us measured the proximal diameters of the left main (LM), left anterior descending (LAD), left circumflex (LCx), and the right coronary (RCA) arteries. Spearman correlations were calculated for the diameters of each coronary artery with treadmill time and for the sum of artery diameters with treadmill time. Linear mixed-effects regression was used to estimate the association between fitness and coronary artery diameters while adjusting for potential confounders. Results: Each coronary artery diameter (LM r=0.12, p=0.009; LAD r=0.11, p=0.02; LCx r=0.10, p=0.02; RCA r=0.18, p<0.0001) and the sum of artery diameters (r=0.19, p<0.0001) were positively correlated with fitness after adjusting for body surface area. The RCA diameter and the sum of artery diameters remained positively correlated with fitness after further adjusting for traditional risk factors. In multivariate analyses, men in the highest fitness quintile had significantly larger coronary artery diameters compared to those in the lowest fitness quintile [β=0.85 mm (SE=0.27)]. A positive linear trend was observed across fitness quintiles and the LM (p=0.008), LAD (p=0.05), RCA (p<0.0001) diameters, and the sum of coronary artery diameters (p=0.0003). When examined continuously, each minute increase in treadmill time was associated with larger diameters (β=0.08 mm (SE=0.02) p<0.001). Conclusion: Higher fitness is positively associated with larger coronary artery diameters.

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