Cyclic Thermal Treatment of Coronary Arteries Limits Smooth Muscle Cell Proliferation Following Balloon Injury: Results in a Porcine Coronary Organ Culture System

1998 ◽  
Vol 31 (2) ◽  
pp. 102A
Author(s):  
K Miyauchi
Keyword(s):  
Cell Proliferation ◽  
Smooth Muscle ◽  
Thermal Treatment ◽  
Organ Culture ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Coronary Arteries ◽  
Culture System ◽  
Balloon Injury ◽  
Organ Culture System

Axial Stretch Increases Cell Proliferation in Arteries in Organ Culture

2000 ◽  
Author(s):  
Hai-Chao Han ◽  
Raymond P. Vito ◽  
Kristin Michael ◽  
David N. Ku
Keyword(s):  
Cell Proliferation ◽  
Smooth Muscle ◽  
Organ Culture ◽  
Vascular Function ◽  
Culture System ◽  
Carotid Arteries ◽  
Ex Vivo ◽  
Axial Stretch ◽  
Organ Culture System ◽  
Physiological Flow

Abstract To study the effect of axial stretch on vascular function and wall remodeling, porcine carotid arteries were cultured under conditions of physiological flow and elevated axial stretch in an ex vivo organ culture system. Smooth muscle cell proliferation was measured by bromodeoxyuridine index. Results showed that cell proliferation was significantly increased in the highly stretched arteries when compared to the normally stretched arteries. This may indicate the feasibility of stimulating new arterial growth by stretching natural arteries.

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