Multimodality treatment of extra-visceral soft tissue sarcomas M0 state of the art and trends

1995 ◽  
Vol 21 (2) ◽  
pp. 125-135 ◽  
Author(s):  
M. Lise ◽  
C.R. Rossi ◽  
S. Alessio ◽  
M. Foletto
Keyword(s):  
Soft Tissue ◽  
State Of The Art ◽  
Soft Tissue Sarcomas ◽  
Multimodality Treatment

Current State-of-the-Art Systemic Therapy for Pediatric Soft Tissue Sarcomas

2012 ◽  
Vol 14 (4) ◽  
pp. 311-319 ◽  
Author(s):  
Anish Ray ◽  
Winston W. Huh
Keyword(s):  
Soft Tissue ◽  
Systemic Therapy ◽  
State Of The Art ◽  
Soft Tissue Sarcomas ◽  
Current State

scholarly journals Progress in the Systemic Treatment of Advanced Soft-Tissue Sarcomas

1998 ◽  
Vol 5 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Scott H. Okuno ◽  
John H. Edmonson
Keyword(s):  
Clinical Trials ◽  
Soft Tissue ◽  
Systemic Treatment ◽  
Soft Tissue Sarcomas ◽  
Multimodality Treatment ◽  
Clinical Situation ◽  
Controlled Clinical Trials ◽  
Systemic Treatments ◽  
Review Current ◽  
Systemic Therapies

Background: Despite the plethora of chemotherapeutic remedies for advanced soft-tissue sarcomas, little evidence has developed to indicate that these efforts have been curative. No controlled comparison has yet proven that patients receiving multidrug regimens survive longer than those receiving doxorubicin alone. Methods: The authors review current systemic treatments and then discuss some investigational efforts now in progress. Also, they seek to demonstrate how the therapies currently available can be integrated with surgery and radiation therapy to accomplish more than might be anticipated from chemotherapy alone. Results: While working to develop better systemic therapies for advanced soft-tissue sarcomas, the integrated use of our best chemotherapy regimens in combination with selected surgical and radiotherapy efforts may provide patients with the best available therapy. Some recent observations involving the use of molgramostim plus chemotherapy have been intriguing. Conclusions: Progress in the systemic treatment of advanced soft-tissue sarcomas may be gradual, but it is real. Our daily challenge is to be certain that we offer each patient the best available multimodality treatment applicable to his or her clinical situation. Molgramostim should be made available for further study with chemotherapy in controlled clinical trials.

Soft tissue sarcomas — Surgical tactics and multimodality treatment

1997 ◽  
Vol 33 ◽  
pp. S117
Author(s):  
P. Klein ◽  
L. Pahike ◽  
B. Reingruber ◽  
J. Göhl ◽  
W. Hohenberger
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Multimodality Treatment ◽  
Surgical Tactics

Multimodality treatment of upper extremity bone and soft tissue sarcomas

Hand Clinics ◽  
2004 ◽  
Vol 20 (2) ◽  
pp. 221-225 ◽  
Author(s):  
William J Maples ◽  
Steven J Buskirk
Keyword(s):  
Soft Tissue ◽  
Upper Extremity ◽  
Soft Tissue Sarcomas ◽  
Multimodality Treatment

The present state of the art in chemotherapy for soft tissue sarcomas in adults: the EORTC point of view

1995 ◽  
Vol 20 (3) ◽  
pp. 193-201 ◽  
Author(s):  
J. Verweij ◽  
H.T. Mouridsen ◽  
O.S. Nielssen ◽  
P.J. Woll ◽  
R. Somers ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Present State ◽  
State Of The Art ◽  
Soft Tissue Sarcomas ◽  
Point Of View

Multimodality Treatment in Adult Patients with High-risk Soft-tissue Sarcomas

2006 ◽  
Vol 5 (1) ◽  
pp. 2-7 ◽  
Author(s):  
Bernd Kasper ◽  
Evelyn Kuehl ◽  
Ludger Bernd ◽  
Anthony D. Ho ◽  
Gerlinde Egerer
Keyword(s):  
High Risk ◽  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Multimodality Treatment ◽  
Adult Patients

Multimodality treatment and reconstructive plastic procedures in soft tissue sarcomas of the trunc and extremities

1993 ◽  
Vol 25 (4) ◽  
pp. 249-252
Author(s):  
H. U. Steinau ◽  
J. Hussmann ◽  
R. Büttemeyer ◽  
D. Hebebrand
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Multimodality Treatment ◽  
Reconstructive Plastic

scholarly journals Preoperative multimodality treatment of large soft tissue sarcomas. How can we get more (function) from less (surgery)?

Cancer ◽  
1993 ◽  
Vol 71 (11) ◽  
pp. 3469-3471 ◽  
Author(s):  
Vernon K. Sondak ◽  
Theodore S. Lawrence
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Multimodality Treatment

scholarly journals Multimodality treatment of locally advanced soft-tissue sarcomas of the extremities

2010 ◽  
Vol 15 (5) ◽  
pp. 119-124 ◽  
Author(s):  
Vincenzo Ravo ◽  
Immacolata Marrone ◽  
Anna Morra ◽  
Roberto Manzo ◽  
Paola Murino ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Locally Advanced ◽  
Soft Tissue Sarcomas ◽  
Multimodality Treatment

Impact of the smallest surgical margin on local recurrence in soft tissue sarcoma treated with surgery with or without radiotherapy: First ten year results of a prospective treatment protocol at Helsinki University Central Hospital

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 10064-10064
Author(s):  
M. Tarkkanen ◽  
M. Sampo ◽  
R. Huuhtanen ◽  
E. Tukiainen ◽  
T. Bohling ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Local Control ◽  
Postoperative Radiotherapy ◽  
Local Treatment ◽  
Treatment Protocol ◽  
Soft Tissue Sarcomas ◽  
Surgical Margin ◽  
Multimodality Treatment ◽  
Central Hospital

10064 Background: A single-institution experience using a prospective treatment protocol for soft tissue sarcoma (STS) of the extremity and trunk wall was reviewed. Special interest of smallest surgical margin on local control was taken. Methods: Between 1987 and 1997 361 patients with STS were treated by the STS Group at Helsinki University Central Hospital. Patients with borderline malignancies or metastatic disease were excluded leaving 270 patients to the present study. All patients included underwent surgery. Postoperative radiotherapy was administered if the smallest surgical margin was less than 2.5 cm when there was no natural barrier, irrespective of tumor grade. Results: With a median follow-up of 6.6 years, the 5-year local control for the whole study population was 76 %. On multivariate analysis, the smallest surgical margin in centimeters, adequacy of treatment according to protocol and postirradiation sarcoma were prognostic for local control. A margin of at least 2,5 cm yielded recurrence-free rate of 89 % at five years. Conclusions: Our findings show that size, depth and grade of the tumor, and patient`s age at diagnosis do not have independent prognostic effect on local control, nor has recurrent disease at referral. Instead, surgical margin in centimeters and adequacy of treatment according to protocol had independent prognostic value for local control. This is encouraging since these factors can be affected by aggressive local treatment. Soft tissue sarcomas should be referred to a specialized multimodality treatment group before biopsy or any surgery. A surgical margin of 2–3 cm yield a reasonable local control in STS even without radiotherapy. No significant financial relationships to disclose.

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