Effects of γ irradiation on the human immunodeficiency virus (HIV) in known HIV-infected human bone-patellar tendon-bone allografts

1993 ◽  
Vol 9 (3) ◽  
pp. 346
Keyword(s):  
Human Immunodeficiency Virus ◽  
Patellar Tendon ◽  
Human Bone ◽  
Γ Irradiation ◽  
Bone Allografts ◽  
Immunodeficiency Virus ◽  
Bone Patellar Tendon

Sterilization Effects on the Mechanical Properties of Human Bone–Patellar Tendon–Bone Allografts

Orthopedics ◽  
2010 ◽  
Author(s):  
James Reid ◽  
Robby Sikka ◽  
William Tsoi ◽  
Steven J. Narvy ◽  
Thomas Hedman ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Patellar Tendon ◽  
Human Bone ◽  
Bone Allografts ◽  
Bone Patellar Tendon

The Biomechanical Effects of 1.0 to 1.2 Mrad of Gamma Irradiation on Human Bone–Patellar Tendon–Bone Allografts

2013 ◽  
Vol 41 (4) ◽  
pp. 835-840 ◽  
Author(s):  
Adam B. Yanke ◽  
Rebecca Bell ◽  
Andrew Lee ◽  
Richard W. Kang ◽  
Richard C. Mather ◽  
...  
Keyword(s):  
Gamma Irradiation ◽  
Patellar Tendon ◽  
Human Bone ◽  
Bone Allografts ◽  
Bone Patellar Tendon

Gamma Irradiation: Effects on Biomechanical Properties of Human Bone-Patellar Tendon-Bone Allografts

1995 ◽  
Vol 23 (5) ◽  
pp. 643-646 ◽  
Author(s):  
Bradley M. Fideler ◽  
C. Thomas Vangsness ◽  
Bin Lu ◽  
Carlo Orlando ◽  
Tilman Moore
Keyword(s):  
Gamma Irradiation ◽  
Patellar Tendon ◽  
Biomechanical Properties ◽  
Human Bone ◽  
Irradiation Effects ◽  
Bone Allografts ◽  
Bone Patellar Tendon

The Effects of Donor Age and Strain Rate on the Biomechanical Properties of Bone-Patellar Tendon-Bone Allografts

1994 ◽  
Vol 22 (3) ◽  
pp. 328-333 ◽  
Author(s):  
Field T. Blevins ◽  
Aaron T. Hecker ◽  
Gregory T. Bigler ◽  
Arthur L. Boland ◽  
Wilson C. Hayes
Keyword(s):  
Strain Rate ◽  
Patellar Tendon ◽  
Biomechanical Properties ◽  
Donor Age ◽  
Bone Allografts ◽  
Bone Patellar Tendon

Effects of 60Co gamma radiation dose on initial structural biomechanical properties of ovine bone—patellar tendon—bone allografts

2010 ◽  
Vol 12 (2) ◽  
pp. 89-98 ◽  
Author(s):  
Kirk C. McGilvray ◽  
Brandon G. Santoni ◽  
A. Simon Turner ◽  
Simon Bogdansky ◽  
Donna L. Wheeler ◽  
...  
Keyword(s):  
Radiation Dose ◽  
Gamma Radiation ◽  
Patellar Tendon ◽  
Biomechanical Properties ◽  
Bone Allografts ◽  
60Co Gamma ◽  
Gamma Radiation Dose ◽  
60Co Gamma Radiation ◽  
Bone Patellar Tendon

scholarly journals Human immunodeficiency virus infection of eosinophils in human bone marrow cultures.

1991 ◽  
Vol 174 (6) ◽  
pp. 1661-1664 ◽  
Author(s):  
A R Freedman ◽  
F M Gibson ◽  
S C Fleming ◽  
C J Spry ◽  
G E Griffin
Keyword(s):  
Bone Marrow ◽  
Human Immunodeficiency Virus ◽  
Reverse Transcriptase Activity ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Rapid Decline ◽  
Immunodeficiency Virus ◽  
Hiv 1

Normal human bone marrow, cultured in vitro with interleukin 5 to promote eosinophil production and maturation, was inoculated with cell-free isolates of human immunodeficiency virus type 1 (HIV-1). CD4 expression by eosinophil precursors, determined by immunocytochemistry, was found to be greatest early in their maturation with a rapid decline after 28 d in culture. Productive HIV infection of eosinophil precursors was detected 14 d after inoculation, by a combination of immunostaining for HIV-1 p24 and gp41/160 and in situ hybridization for viral RNA, together with assay of culture supernatants for p24 antigen and reverse transcriptase activity. Thus, eosinophils are susceptible to productive HIV-1 infection in vitro and may be an important reservoir for the virus in vivo.

scholarly journals Human immunodeficiency virus infection of human bone marrow stromal fibroblasts

Blood ◽  
1990 ◽  
Vol 76 (2) ◽  
pp. 317-322 ◽  
Author(s):  
DT Scadden ◽  
M Zeira ◽  
A Woon ◽  
Z Wang ◽  
L Schieve ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Human Immunodeficiency Virus ◽  
Cell Types ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Stromal Fibroblast ◽  
Stromal Fibroblasts ◽  
Fibroblast Line ◽  
Immunodeficiency Virus

Abstract The human immunodeficiency virus (HIV) preferentially infects CD4 positive T cells and monocytes. Other human cell types have been reported to be infectable with HIV, including cells of mesenchymal origin. In this report, we show that both primary human bone marrow stromal fibroblasts and an immortalized human stromal fibroblast line are susceptible to HIV infection. These cells are capable of passing HIV to cells of lymphoid or myeloid lineage, and may thereby act as a reservoir of virus. This in vitro system may be a useful model for assessing the pathophysiology of hematopoietic dysfunction in AIDS patients.

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