Molecular and cellular mechanisms of early mammalian development: an overview of NIEHS/EPA developmental toxicity workshops

1997 ◽  
Vol 11 (2-3) ◽  
pp. 285-291 ◽  
Author(s):  
J Bishop
Keyword(s):  
Developmental Toxicity ◽  
Mammalian Development ◽  
Cellular Mechanisms ◽  
Early Mammalian Development

scholarly journals Common principles of early mammalian embryo self-organisation

Development ◽  
2020 ◽  
Vol 147 (14) ◽  
pp. dev183079 ◽  
Author(s):  
Berenika Płusa ◽  
Anna Piliszek
Keyword(s):  
Mammalian Development ◽  
Cellular Mechanisms ◽  
Mammalian Embryo ◽  
Early Mammalian Embryo ◽  
Physical Forces ◽  
Self Organisation ◽  
Unifying Principles ◽  
Morphogenic Process ◽  
Early Mammalian Development

ABSTRACTPre-implantation mammalian development unites extreme plasticity with a robust outcome: the formation of a blastocyst, an organised multi-layered structure ready for implantation. The process of blastocyst formation is one of the best-known examples of self-organisation. The first three cell lineages in mammalian development specify and arrange themselves during the morphogenic process based on cell-cell interactions. Despite decades of research, the unifying principles driving early mammalian development are still not fully defined. Here, we discuss the role of physical forces, and molecular and cellular mechanisms, in driving self-organisation and lineage formation that are shared between eutherian mammals.

scholarly journals Breakthroughs and challenges of modern developmental biology and reproductive medicine

2019 ◽  
Vol 63 (3-4-5) ◽  
pp. 77-82
Author(s):  
Simon Fishel ◽  
Anna-Katerina Hadjantonakis ◽  
Berenika Plusa ◽  
Laura Rienzi ◽  
Yojiro Yamanaka ◽  
...  
Keyword(s):  
Developmental Biology ◽  
Reproductive Medicine ◽  
State Of The Art ◽  
Mammalian Development ◽  
Cellular Mechanisms ◽  
Practical Applications ◽  
Mammalian Embryogenesis ◽  
Art Research ◽  
Review State ◽  
Early Mammalian Development

In recent decades we have witnessed unprecedented progress in the field of the developmental biology of mammals. Building on 20th century discoveries, we have managed to increase our understanding of the molecular and cellular mechanisms governing early mammalian embryogenesis and link them to other biological questions, such as stem cells, regeneration, cancer, or tissue and organ formation. Consequently, it has also led to a creation of a completely new branch of reproductive medicine, i.e. assisted reproductive technology (ART). In this Special Issue of The International Journal of Developmental Biology (Int. J. Dev. Biol.) we wished to review state-of-the-art research regarding early mammalian development, from fertilization up to the implantation stage, and discuss its potential meaning for practical applications, including ART. As an introduction to the issue we present a compilation of short essays written by the most renowned scientists in the field, working both in basic and clinical research. The essays are dedicated to the greatest breakthroughs and challenges of 21st century developmental biology and reproductive medicine.

scholarly journals STAT signaling is active during early mammalian development

1997 ◽  
Vol 208 (2) ◽  
pp. 190-198 ◽  
Author(s):  
Stephen A. Duncan ◽  
Zhong Zhong ◽  
Zilong Wen ◽  
James E. Darnell
Keyword(s):  
Mammalian Development ◽  
Stat Signaling ◽  
Early Mammalian Development

scholarly journals Heat shock proteins and their role in early mammalian development

1997 ◽  
Vol 29 (3) ◽  
pp. 139-150 ◽  
Author(s):  
David A Walsh ◽  
Marshall J Edwards MJ ◽  
Murray SR Smith
Keyword(s):  
Heat Shock ◽  
Heat Shock Proteins ◽  
Mammalian Development ◽  
Shock Proteins ◽  
Early Mammalian Development

scholarly journals Mammalian development does not recapitulate suspected key transformations in the evolution of the mammalian middle ear

2015 ◽  
Author(s):  
Héctor Ramirez-Chaves ◽  
Stephen Wroe ◽  
Lynne Selwood ◽  
Lyn Hinds ◽  
Chris Leigh ◽  
...  
Keyword(s):  
Middle Ear ◽  
Mammalian Development ◽  
Positional Change ◽  
Lower Jaw ◽  
Dental Eruption ◽  
Mesozoic Mammals ◽  
Differential Positioning ◽  
Jaw Joint ◽  
Early Mammalian Development ◽  
Land Vertebrates

The tympanic ring, malleus and incus of the mammalian middle ear (MME) derive from the ancestral primary jaw joint of land vertebrates. In Mesozoic mammals, evolutionary detachment of the MME from the lower jaw occurred when Meckel’s cartilage - the last connection between MME and dentary – disappeared. This disappearance is famously recapitulated in early mammalian development. Further developmental recapitulation of Mesozoic MME detachment is thought to occur in the form of negative allometry and posterior/medial replacement of MME bones relative to the jaw joint. However, despite being widely accepted, such detailed recapitulation scenarios have never been quantified. Here we show, based on µCT scans of developmental series of several marsupials and monotremes, that negative allometry of MME bones relative to the skull occurs only after MME detachment, ruling it out as a developmental detachment trigger; additionally, there is no positional change of ectotympanic or malleus relative to the dentary. Differential positioning of MME bones in the two monotreme species is also not developmentally recapitulated. Our results challenge the developmental prerequisites of widely accepted evolutionary scenarios regarding MME detachment. Rather, we observe an association of MME detachment and dental eruption, suggesting a detachment trigger relating to the onset of dentary function.

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