Generalized compact star models with conformal symmetry

We generate a new generalized regular charged anisotropic exact model that admits conformal symmetry in static spherically symmetric spacetime. Our model was examined for physical acceptability as realistic stellar models. The regularity is not violated, the energy conditions are satisfied, the physical forces balanced at equilibrium, the stability is satisfied via adiabatic index, and the surface red shift and mass–radius ratio are within the required bounds. Our conformal charged anisotropic exact solution contains models generated by Finch–Skea, Vaidya–Tikekar and Schwarzschild. Also, some recent charged or neutral and anisotropic or isotropic conformally symmetric models are found as special cases of our exact model. Our approach using a conformal symmetry provides a generalized geometric framework for studying compact objects.

Channeling the Force: Piezo1 Mechanotransduction in Cancer Metastasis

Cancer metastasis is one of the leading causes of death worldwide, motivating research into identifying new methods of preventing cancer metastasis. Recently there has been increasing interest in understanding how cancer cells transduce mechanical forces into biochemical signals, as metastasis is a process that consists of a wide range of physical forces. For instance, the circulatory system through which disseminating cancer cells must transit is an environment characterized by variable fluid shear stress due to blood flow. Cancer cells and other cells can transduce physical stimuli into biochemical responses using the mechanosensitive ion channel Piezo1, which is activated by membrane deformations that occur when cells are exposed to physical forces. When active, Piezo1 opens, allowing for calcium flux into the cell. Calcium, as a ubiquitous second-messenger cation, is associated with many signaling pathways involved in cancer metastasis, such as angiogenesis, cell migration, intravasation, and proliferation. In this review, we discuss the roles of Piezo1 in each stage of cancer metastasis in addition to its roles in immune cell activation and cancer cell death.

Pathogen-derived mechanical cues regulate the spatio-temporal implementation of plant defense

How immune responses are activated and regulated is a central question in immunology. In addition to molecular signaling, recent work has shown that physical forces regulate the immune response of vertebrates by modifying transmembrane protein conformation and cell contact. Mechanical stress and strain produced by forces constitute physical cues perceived by cells instructing gene expression. Whether mechanical cues generated by pathogens during host colonization can trigger adaptive responses in plant cells remains elusive. We found that local and progressive variations of plant cell wall tension caused by fungal pathogen attacks are transmitted to neighboring healthy tissue around the infection site and trigger immunity in distal cells. This thigmoimmunity process requires the reorganization of cortical microtubules and contributes strongly to Arabidopsis disease resistance.

The Impact of the Quark’s Monopole Properties on the Unification of the Fundamental Physical Forces

It is shown that the four fundamental physical forces, i.e. weak interaction, strong interaction, electromagnetism and gravity, all have their origin in the quark as the single true elementary particle.This requires conceiving the quark as a Dirac particle in a pseudo-tachyon mode, which possesses two real dipole moments: the common one associated with its angular momentum and a second one that is polarisable in a scalar field. This Dirac particle carries a regular charge magnetic monopole without Dirac’s string, theorized by Comay. The boson carrier of its field of energy is the gluon showing an exponential decay of its spatial range because of the influence of an omni-present energetic background field, known as the Higgs field, in this article interpreted as the Lambda in Einstein’s Field Equation.

Physical forces driving chlorophyll-a variability in the South Java Sea Shelf: a spatio-temporal analysis

The wind and current are two physical forces that strongly influence the biogeochemistry in coastal waters. Both of these forces could enhance the Chlorophyll-a (Chl-a) concentration through the upwelling process. Here we examine the contribution of the wind and current to the Chl-a variability in the South Java upwelling system in terms of wind stress and bottom stress respectively using satellite-derived and reanalysis data from 2002 to 2017. Ten longitudinally cells were used for further analysis. A long-term Chl-a shows a strong longitudinal gradient of Chl-a with the highest value on the shelf. Seasonal and Inter-annual Chl-a analysis shows the evidence of the monsoonal winds and other forcing effects relevant to the previous studies. Wind stress (τwx ) has a strong seasonal variation which is upwelling- favorable during southeast monsoon coincide with higher Chl-a suggesting wind as the main forces during that time, while bottom stress (τbx ) has more complicated variations, but it’s seen that τwx mostly downwelling-favorable or eastward circulations. There were about 39.92- 52.94% of positive Chl anomalous events generated by the combination of upwelling- favourable τwx and downwelling-favorable τbx , higher than other combinations. In terms of Oceanographic drivers, the wind has a higher effect on enhancing Chl-a through a negative correlation. τwx leads the Chl-a anomalies by about 15 – 24 days with a correlation coefficient of more than 0.6.

Hot to touch: the story of the 2021 Nobel Prize in Physiology or Medicine

ABSTRACT The 2021 Nobel Prize in Physiology or Medicine was awarded to Ardem Patapoutian and David Julius for their research on receptor channels responsible for the perception of touch and temperature. Somatosensation, an overarching sense that enables us to safely interface with the physical forces around and within us, is the fourth sensory modality to be recognized by the Nobel Committee. The story of the discovery of TRP and PIEZO channels, and subsequent investigations into their myriad roles in the perception of noxious and mild temperature, touch, pain, pressure and body position, is an archetype for how translational research into human and animal health is built on a foundation of excellence in basic science.

Natural geometric unit system and electron magnetic moment anomaly

Consequences of implementation of the natural geometric unit system (the SG) based on the pre-2019 SI system, in which four fundamental physical constants undergo joint numerical and dimensional normalization to unity c = G= k = h = 1, with only one base geometric unit u equal to √|h · G/c 3 | m, where the Newtonian gravitational constant G ≈ 6.673 655 205 · 10 -11 m3/(kg · s 2 ), are further explored. In addition to the earlier hypothesized simple electron mass to charge ratio formula me = e/(2 9πα), and formulas for stable quarks rest masses: quark u mu = √(⅔) / (2 7π √(πα)) u, equivalent of 2.360 MeV/c 2 and quark d md = √(⅓) -1 / (2 7π √(πα)) u, equivalent of 5.007 MeV/c 2 , a simple formula for electron magnetic moment anomaly is proposed α/2π - (α/2π) 2 - 2 8 (α/2π) 3 - 2 12 (α/2π) 4 - 2 16 (α/2π) 5 - 2 24 (α/2π) 6 ≈ 0.001 159 652 180. The finding supports the research area of purely geometric modelling of the fundamental physical forces and their unification. It seems plausible, that in the SG, with use of half integer powers of 2, 3, π and α only,all the fundamental properties of stable matter and electromagnetic radiation could be described

New Public Excavations

The paper draws on recent salvage archaeological excavations in Melbourne, Australia that prompt questions on architectural concerns of ‘site’ in contemporary architectural discourse. For design practitioners, site is usually communicated in direct and straightforward ways, with some practical understanding of the physical forces that form the current site, but little of influencing political or cultural elements. This is particularly problematic in settler-colonial cities such as Melbourne which are built out of complex and contested environments. The urban archaeological excavation is therefore seen as a metaphorical ‘autopsy,’ a brief moment of pause when the site’s history and composition can be publicly examined and challenged. Crucially, the act exposes the significant and potent presence of ground and dirt as actants in the city. This paper examines archaeological and architectural texts and practices to explore the added meaning that a refocusing on dirt and ground as material and medium can add to the architectural reading and interpretation of site in the settler‑colonial city.

An update on passive transport in and out of plant cells

Transport across membranes is critical for plant survival. Membranes are the interfaces at which plants interact with their environment. The transmission of energy and molecules into cells provides plants with the source material and power to grow, develop, defend, and move. An appreciation of the physical forces that drive transport processes is thus important for understanding plant growth and development. We focus on the passive transport of molecules, describing the fundamental concepts and demonstrating how different levels of abstraction can lead to different interpretations of the driving forces. We summarise recent developments on quantitative frameworks for describing diffusive and bulk flow transport processes in and out of cells, with a more detailed focus on plasmodesmata, and outline open questions and challenges.

The Impact of the Quark’s Monopole Properties on the Unification of the Fundamental Physical Forces

It is shown that the four fundamental physical forces, i.e. weak interaction, strong interaction, electromagnetism and gravity, all have their origin in the quark as the single true elementary particle.This requires conceiving the quark as a Dirac particle in a pseudo-tachyon mode, which possesses two real dipole moments: the common one associated with its angular momentum and a second one that is polarisable in a scalar field. This Dirac particle carries a regular charge magnetic monopole without Dirac’s string, theorized by Comay. The boson carrier of its field of energy is the gluon showing an exponential decay of its spatial range because of the influence of an omni-present energetic background field, known as the Higgs field, in this article interpreted as the Lambda in Einstein’s Field Equation.