scholarly journals Brain Penetrance, Receptor Occupancy and Antistress In Vivo Efficacy of a Small Molecule Corticotropin Releasing Factor Type I Receptor Selective Antagonist

2002 ◽  
Vol 27 (2) ◽  
pp. 194-202 ◽  
Author(s):  
S Heinrichs
Keyword(s):  
Small Molecule ◽  
Receptor Occupancy ◽  
Corticotropin Releasing Factor ◽  
Type I ◽  
In Vivo Efficacy ◽  
Selective Antagonist ◽  
Factor Type

Enhanced in vivo efficacy of a long-life type I Interferon superagonist in a mouse model of multiple sclerosis

2014 ◽  
Vol 275 (1-2) ◽  
pp. 219
Author(s):  
Daniel Harari ◽  
Nadine Kallweit ◽  
Renne Abramovich ◽  
Keren Sasson ◽  
Alla Zozulya ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Mouse Model ◽  
Type I Interferon ◽  
Type I ◽  
In Vivo Efficacy ◽  
Long Life ◽  
Life Type

Identification and in vivo efficacy of small-molecule antagonists of integrin αvβ3 (the vitronectin receptor)

2000 ◽  
Vol 5 (9) ◽  
pp. 397-408 ◽  
Author(s):  
William H Miller ◽  
Richard M Keenan ◽  
Robert N Willette ◽  
Michael W Lark
Keyword(s):  
Small Molecule ◽  
Integrin Αvβ3 ◽  
Vitronectin Receptor ◽  
In Vivo Efficacy

Ligand Affinity for Amino-Terminal and Juxtamembrane Domains of the Corticotropin Releasing Factor Type I Receptor:  Regulation by G-Protein and Nonpeptide Antagonists

Biochemistry ◽  
2004 ◽  
Vol 43 (13) ◽  
pp. 3996-4011 ◽  
Author(s):  
Sam R. J. Hoare ◽  
Sue K. Sullivan ◽  
David A. Schwarz ◽  
Nicholas Ling ◽  
Wylie W. Vale ◽  
...  
Keyword(s):  
G Protein ◽  
Corticotropin Releasing Factor ◽  
Receptor Regulation ◽  
Type I ◽  
Ligand Affinity ◽  
Amino Terminal ◽  
Factor Type

scholarly journals MPZP: A novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist

2008 ◽  
Vol 88 (4) ◽  
pp. 497-510 ◽  
Author(s):  
H RICHARDSON ◽  
Y ZHAO ◽  
E FEKETE ◽  
C FUNK ◽  
P WIRSCHING ◽  
...  
Keyword(s):  
Small Molecule ◽  
Corticotropin Releasing Factor ◽  
Crf1 Antagonist ◽  
Factor Type
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